Abstract：
:Genetic analysis of 131 independent transpositions of the tetracycline-resistance element Tn10 from a single site in phage P22 into the histidine operon of Salmonella typhimurium reveals that Tn10 insertions are not randomly distributed along this chromosomal target. The insertions occur in 22 different "clusters"; insertions within each cluster are very tightly linked in recombination tests. Tn10 insertions are not evenly distributed among the identified clusters. The existence of these clusters suggests that this chromosomal target contains particular genetic signals that guide Tn10 to particular preferred positions for insertion. Insertions within each cluster occur in both orientations with roughly equal frequency.--The relationship among different insertions within each cluster has been examined. The resolution of genetic mapping places an upper limit of about 50 basepairs on the distance between different insertions within a cluster. Different insertions within a cluster usually have the same reversion frequency; however, heterogeneity in reversion frequency has been detected in at least two clusters. For most clusters, the available data are consistent with the simple possibility that all insertions within a cluster are at identical positions; however, the data do not exclude other possibilities.
journal_name
Geneticsjournal_title
Geneticsauthors
Kleckner N,Steele DA,Reichardt K,Botstein Dsubject
Has Abstractpub_date
1979-08-01 00:00:00pages
1023-40issue
4eissn
0016-6731issn
1943-2631journal_volume
92pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genet...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.052977
更新日期：2006-07-01 00:00:00
abstract：:In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.160705
更新日期：2014-04-01 00:00:00
abstract：:We have genetically analyzed, cloned and physically mapped the modified cytosine-specific restriction determinants mcrA (rglA) and mcrB (rglB) of Escherichia coli K-12. The independently discovered Rgl and Mcr restriction systems are shown to be identical by three criteria: 1) mutants with the RglA- or RglB- phenotype...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302324
更新日期：2019-10-01 00:00:00
abstract：:Signaling by receptor tyrosine kinases (RTKs) is critical for a multitude of developmental decisions and processes. Among the molecules known to transduce the RTK-generated signal is the nonreceptor protein tyrosine phosphatase Corkscrew (Csw). Previously, Csw has been demonstrated to function throughout the Drosophil...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:Previous work showed that C. elegans gon-14 is required for gonadogenesis. Here we report that gon-14 encodes a protein with similarity to LIN-15B, a class B synMuv protein. An extensive region of GON-14 contains blocks of sequence similarity to transposases of the hAT superfamily, but key residues are not conserved, ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.048751
更新日期：2006-02-01 00:00:00
abstract：:Following the advent of a gene targeting technique in Drosophila, different methods have been developed to modify the Drosophila genome. The initial demonstration of gene targeting in flies used an ends-in method, which generates a duplication of the target locus. The duplicated locus can then be efficiently reduced t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.030882
更新日期：2004-11-01 00:00:00
abstract：:The HML and HMR loci carry unexpressed copies of MATa and MAT alpha information, and a replica of that information is transposed to MAT during mating-type interchange in Saccharomyces yeasts. A negative control mechanism keeps silent the information located at the HML and HMR loci. We mapped these loci by constructing...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:The genotypes of three color mutants in goldfish: a depigmentation character of larval melanophores, albinism and a recessive-transparent character, were analyzed by crossing experiments. The depigmentation character in the common goldfish is controlled by two dominant multiple genes, Dp1 and Dp2, and only fish with d...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-05-01 00:00:00
abstract：:The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume composition...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate between separation-of-...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.147801
更新日期：2013-03-01 00:00:00
abstract：:We analyze nucleotide polymorphism data for a large number of loci in areas of normal to high recombination in Drosophila melanogaster and D. simulans (24 and 16 loci, respectively). We find a genome-wide, systematic departure from the neutral expectation for a panmictic population at equilibrium in natural population...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.166.2.1105
更新日期：2004-02-01 00:00:00
abstract：:Septin proteins bind GTP and heterooligomerize into filaments with conserved functions across a wide range of eukaryotes. Most septins hydrolyze GTP, altering the oligomerization interfaces; yet mutations designed to abolish nucleotide binding or hydrolysis by yeast septins perturb function only at high temperatures. ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.161182
更新日期：2014-03-01 00:00:00
abstract：:Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in C. elegans are conserved across metazoan species, including humans...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.118.301367
更新日期：2019-01-01 00:00:00
abstract：:The 73AD salivary chromosome region of Drosophila melanogaster was subjected to mutational analysis in order to (1) generate a collection of chromosome breakpoints that would allow a correlation between the genetic, cytological and molecular maps of the region and (2) define the number and gross organization of comple...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.087361
更新日期：2008-12-01 00:00:00
abstract：:By screening for suppressors of hypomorphic mutations of let-23, a receptor tyrosine kinase necessary for vulval induction in Caenorhabditis elegans, we recovered > or = 12 mutations defining the sli-1 (suppressor of lineage defect) locus. sli-1 mutations suppress four of five phenotypes associated with hypomorphic al...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:The SUF13 and SUF14 genes were identified among extragenic suppressors of +1 frameshift mutations. SUF13 is synonymous with MBF1, a single-copy nonessential gene coding for a POLII transcription factor. The suf13-1 mutation is a two-nucleotide deletion in the SUF13/MBF1 coding region. A suf13::TRP1 null mutant suppres...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:Adaptive dynamics formalism demonstrates that, in a constant environment, a continuous trait may first converge to a singular point followed by spontaneous transition from a unimodal trait distribution into a bimodal one, which is called "evolutionary branching." Most previous analyses of evolutionary branching have b...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.144980
更新日期：2013-01-01 00:00:00
abstract：:Recombination and chromosome synapsis bring homologous chromosomes together, creating chiasmata that ensure accurate disjunction during reductional division. SPO13 is a key gene required for meiosis I (MI) reductional segregation, but dispensable for recombination, in Saccharomyces cerevisiae. Absence of SPO13 leads t...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:Microsatellite markers are extensively used to evaluate genetic diversity in natural or experimental evolving populations. Their high degree of polymorphism reflects their high mutation rates. Estimates of the mutation rates are therefore necessary when characterizing diversity in populations. As a complement to the c...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.071332
更新日期：2008-08-01 00:00:00
abstract：:For more than 60 years, evolutionary cytogeneticists have been using naturally occurring chromosomal inversions to infer phylogenetic histories, especially in insects with polytene chromosomes. The validity of this method is predicated on the assumption that inversions arise only once in the history of a lineage, so t...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associa...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic drive, each providing distinct functions th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.160697
更新日期：2014-03-01 00:00:00
abstract：:The shibire locus of Drosophila melanogaster encodes dynamin, a GTPase required for the fission of endocytic vesicles from plasma membrane. Biochemical studies indicate that mammalian dynamin is part of a complex containing multiple dynamin subunits and other polypeptides. To gain insight into sequences of dynamin cri...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:The net rate of mutation to deleterious but nonlethal alleles and the sizes of effects of these mutations are of great significance for many evolutionary questions. Here we describe three replicate experiments in which mutations have been accumulated on chromosome 3 of Drosophila melanogaster by means of single-male b...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.103.025262
更新日期：2004-06-01 00:00:00
abstract：:We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.179093
更新日期：2015-11-01 00:00:00
abstract：:Aggression is a complex social behavior that is widespread in nature. To date, only a limited number of genes that affect aggression have been identified, in large part because the complexity of the phenotype makes screening difficult and time-consuming regardless of the species that is studied. We discovered that agg...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300292
更新日期：2018-01-01 00:00:00
