Abstract：
:Aggression is a complex social behavior that is widespread in nature. To date, only a limited number of genes that affect aggression have been identified, in large part because the complexity of the phenotype makes screening difficult and time-consuming regardless of the species that is studied. We discovered that aggressive group-housed Drosophila melanogaster males inflict damage on each other's wings, and show that wing damage negatively affects their ability to fly and mate. Using this wing-damage phenotype, we screened males from ∼1400 chemically mutagenized strains and found ∼40 mutant strains with substantial wing damage. Five of these mutants also had increased aggressive behavior. To identify the causal mutation in one of our top aggressive strains, we used whole-genome sequencing and genomic duplication rescue strategies. We identified a novel mutation in the voltage-gated potassium channel Shaker (Sh) and show that a nearby previously identified Sh mutation also results in increased aggression. This simple screen can be used to dissect the molecular mechanisms underlying aggression.
journal_name
Geneticsjournal_title
Geneticsauthors
Davis SM,Thomas AL,Liu L,Campbell IM,Dierick HAdoi
10.1534/genetics.117.300292subject
Has Abstractpub_date
2018-01-01 00:00:00pages
273-282issue
1eissn
0016-6731issn
1943-2631pii
genetics.117.300292journal_volume
208pub_type
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