Genetic and physical mapping of the mcrA (rglA) and mcrB (rglB) loci of Escherichia coli K-12.

abstract：:We compared allele sequences of two loci near the Arabidopsis lyrata self-incompatibility (S) loci with sequences of A. thaliana orthologs and found high numbers of shared polymorphisms, even excluding singletons and sites likely to be highly mutable. This suggests maintenance of entire S-haplotypes for long evolution...

journal_title：Genetics

authors： Charlesworth D,Kamau E,Hagenblad J,Tang C

更新日期：2006-04-01 00:00:00

abstract：:RNAs are localized by microtubule-based pathways to both the anterior and posterior poles of the developing Drosophila oocyte. We describe a new gene, wispy, required for localization of mRNAs to both poles of the egg. Embryos from wispy mothers arrest development after abnormal oocyte meiosis and failure of pronuclei...

journal_title：Genetics

authors： Brent AE,MacQueen A,Hazelrigg T

更新日期：2000-04-01 00:00:00

abstract：:Injury triggers regeneration of axons and dendrites. Research has identified factors required for axonal regeneration outside the CNS, but little is known about regeneration triggered by dendrotomy. Here, we study neuronal plasticity triggered by dendrotomy and determine the fate of complex PVD arbors following laser ...

journal_title：Genetics

authors： Oren-Suissa M,Gattegno T,Kravtsov V,Podbilewicz B

更新日期：2017-05-01 00:00:00

abstract：:There have been several attempts to estimate the average dominance (ratio of heterozygous to homozygous effects) of spontaneous deleterious mutations in Drosophila melanogaster, but these have given inconsistent results. We investigated whether transposable element (TE) insertions have higher average dominance for egg...

journal_title：Genetics

authors： Fry JD,Nuzhdin SV

更新日期：2003-04-01 00:00:00

abstract：:We have selected 210 mutants able to grow on sucrose in the presence of 2-deoxyglucose. We identified recessive mutations in three major complementation groups that cause constitutive (glucose-insensitive) secreted invertase synthesis. Two groups comprise alleles of the previously identified HXK2 and REG1 genes, and t...

journal_title：Genetics

authors： Neigeborn L,Carlson M

更新日期：1987-02-01 00:00:00

abstract：:DNA topoisomerases, enzymes that alter the superhelicity of DNA, have been implicated in such critical cellular functions as transcription, DNA replication, and recombination. In the yeast Saccharomyces cerevisiae, a null mutation in the gene encoding topoisomerase I (TOP1) causes elevated levels of mitotic recombinat...

journal_title：Genetics

authors： Levin NA,Bjornsti MA,Fink GR

更新日期：1993-04-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:Bacteriophage T4 DNA metabolism is largely insulated from that of its host, although some host functions assist in the repair of T4 DNA damage. Environmental factors sometimes affect survival and mutagenesis after ultraviolet (UV) irradiation of T4, and can affect mutagenesis in many organisms. We therefore tested the...

journal_title：Genetics

authors： Smith LA,Drake JW

更新日期：1998-04-01 00:00:00

abstract：:The sequentially Markov coalescent is a simplified genealogical process that aims to capture the essential features of the full coalescent model with recombination, while being scalable in the number of loci. In this article, the sequentially Markov framework is applied to the conditional sampling distribution (CSD), ...

journal_title：Genetics

authors： Paul JS,Steinrücken M,Song YS

更新日期：2011-04-01 00:00:00

abstract：:Five bivariate distributions of wing dimensions of Drosophila melanogaster were measured, in flies 1) subjected to four defined environmental regimes during development, 2) taken directly from nature in seven U.S. states, 3) selected in ten populations for change in wing form, and 4) sampled from 21 long inbred wild-t...

journal_title：Genetics

authors： Weber KE

更新日期：1990-12-01 00:00:00

abstract：:DNA methylation is a chromatin modification that contributes to epigenetic regulation of gene expression. The inheritance patterns and trans-generational stability of 962 differentially methylated regions (DMRs) were assessed in a panel of 71 near-isogenic lines (NILs) derived from maize (Zea mays) inbred lines B73 an...

journal_title：Genetics

authors： Li Q,Eichten SR,Hermanson PJ,Springer NM

更新日期：2014-03-01 00:00:00

abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...

journal_title：Genetics

authors： Birkner M,Blath J,Eldon B

更新日期：2013-01-01 00:00:00

abstract：:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 tra...

journal_title：Genetics

authors： Weber AL,Briggs WH,Rucker J,Baltazar BM,de Jesús Sánchez-Gonzalez J,Feng P,Buckler ES,Doebley J

更新日期：2008-10-01 00:00:00

abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...

journal_title：Genetics

authors： Schreck N,Piepho HP,Schlather M

更新日期：2019-10-01 00:00:00

abstract：:Thirty-four independent nonviable c-locus mutations (types cal, albino lethal and cas, albino subvital), derived from radiation experiments, were tested for involvement of nearby markers tp, Mod-2, sh-1, and Hbb: 10, 22, and 2 involved, respectively, none of these markers, Mod-2 alone, and Mod-2 plus sh-1. When classi...

journal_title：Genetics

authors： Russell LB,Montgomery CS,Raymer GD

更新日期：1982-03-01 00:00:00

abstract：:Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sle...

journal_title：Genetics

authors： Flavell SW,Raizen DM,You YJ

更新日期：2020-10-01 00:00:00

abstract：:We have characterized the MPH1 gene from Saccharomyces cerevisiae. mph1 mutants display a spontaneous mutator phenotype. Homologs were found in archaea and in the EST libraries of Drosophila, mouse, and man. Mph1 carries the signature motifs of the DEAH family of helicases. Selected motifs were shown to be necessary f...

journal_title：Genetics

authors： Scheller J,Schürer A,Rudolph C,Hettwer S,Kramer W

更新日期：2000-07-01 00:00:00

abstract：:We consider some practical statistical issues in QTL analysis where several crosses originate in multiple inbred parents. Our results show that ignoring background polygenic variation in different crosses may lead to biased interval mapping estimates of QTL effects or loss of efficiency. Threshold and power approximat...

journal_title：Genetics

authors： Zou F,Yandell BS,Fine JP

更新日期：2001-07-01 00:00:00

abstract：:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were de...

journal_title：Genetics

authors： Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SS

更新日期：1987-01-01 00:00:00

abstract：:Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...

journal_title：Genetics

authors： Lamb JC,Danilova T,Bauer MJ,Meyer JM,Holland JJ,Jensen MD,Birchler JA

更新日期：2007-03-01 00:00:00

abstract：:USING A NEWLY DEVELOPED PLATING SYSTEM, WE HAVE MEASURED CELL SURVIVAL AND THE FREQUENCIES OF VARIATION IN AN INHERITED TRAIT AFTER TREATMENT OF SOYBEAN CELL SUSPENSIONS WITH DIFFERENT MUTAGENS: ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS), N-Methyl-N'-nitro-N-nitroso-guanidine (MNNG), hycanthone (1-{[2...

journal_title：Genetics

authors： Weber G,Lark KG

更新日期：1980-09-01 00:00:00

abstract：:Heterozygotes for three long inversions on chromosome 1 were analyzed by serial reconstruction from electron micrographs. Measurements of loop lengths at different meiotic prophase substages revealed that the homologous synapsis of the inverted region was gradually replaced by nonhomologous synapsis as loops were elim...

journal_title：Genetics

authors： Bojko M

更新日期：1990-03-01 00:00:00

abstract：:Establishing durable disease resistance in agricultural crops, where much of the plant defense is provided through effector-R gene interactions, is complicated by the ability of pathogens to overcome R gene resistance by losing the corresponding effector gene. Many proposed methods to maintain disease resistance in th...

journal_title：Genetics

authors： Wichmann G,Bergelson J

更新日期：2004-02-01 00:00:00

abstract：:A series of clear mutants of the temperate phage 16-3 of Rhizobium meliloti were isolated that included various point and deletion mutants of the C cistron, coding for the phage repressor. It was observed that recombinant genotypes, such as c(+) and ti (temperature-sensitive allele), which form turbid plaques, can be ...

journal_title：Genetics

authors： Orosz L

更新日期：1980-02-01 00:00:00

abstract：:The fixation of a beneficial allele in a population leaves a well-characterized signature in patterns of nucleotide variation at linked sites. This signature can be used to estimate the time since fixation from patterns of polymorphism in extant individuals. I introduce a method to assess the support in polymorphism d...

journal_title：Genetics

authors： Przeworski M

更新日期：2003-08-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:Translocations between the two large autosomes were scored in the progeny of males that had been fed mitomycin-C. The frequencies were the same in spermatogonia sampled after 12 and 25 days and in spermatozoa stored for the same periods in untreated females. ...

journal_title：Genetics

authors： Shukla PT,Auerbach C

更新日期：1979-10-01 00:00:00

abstract：:COTRANS is a program for analyzing cotransduction data. It calculates distances from pairwise cotransduction frequencies, computes crossovers required to obtain each observed recombinant class, and applies rules to draw conclusions about order. The rules are based on the correlation between the frequency of the classe...

journal_title：Genetics

authors： Berlyn MB,Letovsky S

更新日期：1992-05-01 00:00:00

abstract：:Motile and immotile (or primary) cilia are microtubule-based structures that mediate multiple cellular functions, including the transduction of environmental cues, developmental signaling, cellular motility, and modulation of fluid flow. Although their core architectures are similar, motile and primary cilia exhibit m...

journal_title：Genetics

authors： Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

更新日期：2017-12-01 00:00:00

abstract：:In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...

journal_title：Genetics

authors： Engels WR

更新日期：1981-07-01 00:00:00