Statistical issues in the analysis of quantitative traits in combined crosses.

abstract：:Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...

journal_title：Genetics

authors： Hand ML,Koltunow AM

更新日期：2014-06-01 00:00:00

abstract：:The Genetics Society of America's (GSA) Edward Novitski Prize is awarded to researchers who have solved challenging problems in genetics through experiments that demonstrate exceptional creativity and ingenuity. Job Dekker of the University of Massachusetts Medical School has been selected for the 2018 award in recogn...

journal_title：Genetics

authors： Haloupek N

更新日期：2018-11-01 00:00:00

abstract：:The rag4 mutant of Kluyveromyces lactis was previously isolated as a fermentation-deficient mutant, in which transcription of the major glucose transporter gene RAG1 was affected. The wild-type RAG4 was cloned by complementation of the rag4 mutation and found to encode a protein homologous to Snf3 and Rgt2 of Saccharo...

journal_title：Genetics

authors： Betina S,Goffrini P,Ferrero I,Wésolowski-Louvel M

更新日期：2001-06-01 00:00:00

abstract：:Studies in the fly, Drosophila melanogaster, have revealed that several signaling pathways are important for the regulation of growth. Among these, the insulin receptor/phosphoinositide 3-kinase (PI3K) pathway is remarkable in that it affects growth and final size without disturbing pattern formation. We have used a s...

journal_title：Genetics

authors： Coelho CM,Kolevski B,Walker CD,Lavagi I,Shaw T,Ebert A,Leevers SJ,Marygold SJ

更新日期：2005-10-01 00:00:00

abstract：:OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for identifying conserved genes for research into biological and disease mechanisms. However, the efficacy of orthology prediction depends on th...

journal_title：Genetics

authors： Kim W,Underwood RS,Greenwald I,Shaye DD

更新日期：2018-10-01 00:00:00

abstract：:We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering approximately 77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verifi...

journal_title：Genetics

authors： Ryder E,Ashburner M,Bautista-Llacer R,Drummond J,Webster J,Johnson G,Morley T,Chan YS,Blows F,Coulson D,Reuter G,Baisch H,Apelt C,Kauk A,Rudolph T,Kube M,Klimm M,Nickel C,Szidonya J,Maróy P,Pal M,Rasmuson-Lestan

更新日期：2007-09-01 00:00:00

abstract：:Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...

journal_title：Genetics

authors： Zhang S,Binari R,Zhou R,Perrimon N

更新日期：2010-04-01 00:00:00

abstract：:Heterochromatin is a specialized chromatin structure in chromosomal regions associated with repeated DNA sequences and low concentrations of genes. Formation of heterochromatin is determined in large part by enzymes that modify histones and structural proteins that bind to these modified histones in a cooperative fash...

journal_title：Genetics

authors： Mason JM,Ransom J,Konev AY

更新日期：2004-11-01 00:00:00

abstract：:mod(mdg4), also known as E(var)3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death. We have isolated a large number of mod(mdg4) cDNAs, representing 21 diff...

journal_title：Genetics

authors： Büchner K,Roth P,Schotta G,Krauss V,Saumweber H,Reuter G,Dorn R

更新日期：2000-05-01 00:00:00

abstract：:In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...

journal_title：Genetics

authors： Schüpbach T

更新日期：1985-03-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate stimulus-dependent activation of cognate heterotrimeric G-proteins, triggering ensuing downstream cellular responses. Tight regulation of GPCR-evoked pathways is required because prolonged stimulation can be detrimental to an organism. St...

journal_title：Genetics

authors： Alvaro CG,Aindow A,Thorner J

更新日期：2016-05-01 00:00:00

abstract：:The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. T...

journal_title：Genetics

authors： Kelly JK

更新日期：1997-07-01 00:00:00

abstract：:The Snf1 protein kinase of the glucose signaling pathway in Saccharomyces cerevisiae is regulated by an autoinhibitory interaction between the regulatory and catalytic domains of Snf1p. Transitions between the autoinhibited and active states are controlled by an upstream kinase and the Reg1p-Glc7p protein phosphatase ...

journal_title：Genetics

authors： Kuchin S,Vyas VK,Kanter E,Hong SP,Carlson M

更新日期：2003-02-01 00:00:00

abstract：:NudC encodes a protein of unknown biochemical function that is required for nuclear migration. In an attempt to define its function by identifying interacting proteins, a screen for extragenic suppressors of the temperature-sensitive nudC3 mutation was undertaken that identified nine snc genes. Here we demonstrate tha...

journal_title：Genetics

authors： Chiu YH,Morris NR

更新日期：1997-03-01 00:00:00

abstract：:There are many types of DNA damage that are repaired by a multiplicity of different repair pathways. All damage and repair occur in the context of chromatin, and histone modifications are involved in many repair processes. We have analyzed the roles of H2A and its modifications in repair by mutagenizing modifiable res...

journal_title：Genetics

authors： Moore JD,Yazgan O,Ataian Y,Krebs JE

更新日期：2007-05-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00

abstract：:The recent progress in sequencing technologies makes possible large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The results of such efforts depend heavily on the use of efficient study designs and analytical methods. We introduce here a unified framework for associat...

journal_title：Genetics

authors： Ionita-Laza I,Ottman R

更新日期：2011-11-01 00:00:00

abstract：:We previously isolated a pollen factor, ui6.1, which encodes a Cullin1 protein (CUL1) that functions in unilateral interspecific incompatibility (UI) in Solanum. Here we show that CUL1 is also required for pollen function in self-incompatibility (SI). We used RNA interference (RNAi) to reduce CUL1 expression in pollen...

journal_title：Genetics

authors： Li W,Chetelat RT

更新日期：2014-02-01 00:00:00

abstract：:Clustering individuals to subpopulations based on genetic data has become commonplace in many genetic studies. Inference about population structure is most often done by applying model-based approaches, aided by visualization using distance-based approaches such as multidimensional scaling. While existing distance-bas...

journal_title：Genetics

authors： Greenbaum G,Templeton AR,Bar-David S

更新日期：2016-04-01 00:00:00

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00

abstract：:The MITF protein is a member of the MYC family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors and is most closely related to the TFE3, TFEC, and TFEB proteins. In the mouse, MITF is required for the development of several different cell types, including the retinal pigment epithelial (RPE) c...

journal_title：Genetics

authors： Hallsson JH,Haflidadóttir BS,Stivers C,Odenwald W,Arnheiter H,Pignoni F,Steingrímsson E

更新日期：2004-05-01 00:00:00

abstract：:Life-history traits or "fitness components"-such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span-are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding ...

journal_title：Genetics

authors： Flatt T

更新日期：2020-01-01 00:00:00

abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...

journal_title：Genetics

authors： Norris AD,Kim HM,Colaiácovo MP,Calarco JA

更新日期：2015-10-01 00:00:00

abstract：:Using conditional probabilities and moment-generating matrices, I derived approximate algebraic equations that give expectations of gene frequency, population mean, gene frequency variance within lines, or heterozygosity, and gene frequency variance between lines, or drift, for repeated cycles of recurrent selection i...

journal_title：Genetics

authors： Silvela L

更新日期：1980-07-01 00:00:00

abstract：:In multigene families, variation among loci and alleles can contribute to trait evolution. We explored patterns of functional and genetic variation in six duplicated Arabidopsis thaliana trypsin inhibitor (ATTI) loci. We demonstrate significant variation in constitutive and herbivore-induced transcription among ATTI l...

journal_title：Genetics

authors： Clauss MJ,Mitchell-Olds T

更新日期：2004-03-01 00:00:00

abstract：:The effective population size (N(e)) is notoriously difficult to accurately estimate in wild populations as it is influenced by a number of parameters that are difficult to delineate in natural systems. The different methods that are used to estimate N(e) are affected variously by different processes at the population...

journal_title：Genetics

authors： Serbezov D,Jorde PE,Bernatchez L,Olsen EM,Vøllestad LA

更新日期：2012-06-01 00:00:00

abstract：:We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) w...

journal_title：Genetics

authors： Niculita-Hirzel H,Stöck M,Perrin N

更新日期：2008-07-01 00:00:00

abstract：:The small subunit ribosomal RNA gene (srDNA) has been used extensively for phylogenetic analyses. One common assumption in these analyses is that substitution rates are biased toward transitions. We have developed a simple method for estimating relative rates of base change that does not assume rate constancy and take...

journal_title：Genetics

authors： Vawter L,Brown WM

更新日期：1993-06-01 00:00:00

abstract：:At least six nuclear loci are responsible for the genetic control of malate dehydrogenase (L-malate: NAD oxidoreductase; EC 1.1.1.37; MDH) in coleoptiles of maize. Three independently segregating loci (Mdh1, Mdh2, Mdh3) govern the production of MDH isozymes resistant to inactivation by ascorbic acid and found largely ...

journal_title：Genetics

authors： Goodman MM,Stuber CW,Lee CN,Johnson FM

更新日期：1980-01-01 00:00:00

abstract：:A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The...

journal_title：Genetics

authors： Cobbs G

更新日期：1986-06-01 00:00:00