A test of neutrality based on interlocus associations.

abstract：:Motile and immotile (or primary) cilia are microtubule-based structures that mediate multiple cellular functions, including the transduction of environmental cues, developmental signaling, cellular motility, and modulation of fluid flow. Although their core architectures are similar, motile and primary cilia exhibit m...

journal_title：Genetics

authors： Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

更新日期：2017-12-01 00:00:00

abstract：:Aimed at investigating the recovery of a specific mutant allele of the mating type locus (MAT) by switching a defective MAT allele, these experiments provide information bearing on several models proposed for MAT interconversion in bakers yeast, Saccharomyces cerevisiae. Hybrids between heterothallic (ho) cells carryi...

journal_title：Genetics

authors： Klar AJ,Fogel S,Radin DN

更新日期：1979-07-01 00:00:00

abstract：:New rudimentary (r) mutants have been isolated following mutagenesis with ethyl methanesulfonate (r(LE)), ICR-170 (r(LI)) and X rays (r(LX)). From wing phenotype measurements on homoallelic females, it has been shown that the r(LE) mutant series includes several leaky alleles, as well as alleles that produce moderate ...

journal_title：Genetics

authors： Rawls JM,Porter LA

更新日期：1979-09-01 00:00:00

abstract：:BTB-zinc finger transcription factors play many important roles in metazoan development. In these proteins, the BTB domain is critical for dimerization and for recruiting cofactors to target genes. Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. He...

journal_title：Genetics

authors： Howell K,Arur S,Schedl T,Sundaram MV

更新日期：2010-04-01 00:00:00

abstract：:Many data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of can be ...

journal_title：Genetics

authors： Achaz G

更新日期：2008-07-01 00:00:00

abstract：:In vivo haploid induction (HI) triggered by pollination with special intraspecific genotypes, called inducers, is unique to Zea maysL. within the plant kingdom and has revolutionized maize breeding during the last decade. However, the molecular mechanisms underlying HI in maize are still unclear. To investigate the ge...

journal_title：Genetics

authors： Hu H,Schrag TA,Peis R,Unterseer S,Schipprack W,Chen S,Lai J,Yan J,Prasanna BM,Nair SK,Chaikam V,Rotarenco V,Shatskaya OA,Zavalishina A,Scholten S,Schön CC,Melchinger AE

更新日期：2016-04-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...

journal_title：Genetics

authors： Malavazi I,Lima JF,de Castro PA,Savoldi M,de Souza Goldman MH,Goldman GH

更新日期：2008-02-01 00:00:00

abstract：:We show that major chromosomal rearrangements can occur upon T-DNA transformation of Arabidopsis thaliana. In the ACL4 line, two T-DNA insertion loci were found; one is a tandem T-DNA insert in a head-to-head orientation, and the other is a truncated insert with only the left part of the T-region. The four flanking DN...

journal_title：Genetics

authors： Nacry P,Camilleri C,Courtial B,Caboche M,Bouchez D

更新日期：1998-06-01 00:00:00

abstract：:In many plant species, exposure to a prolonged period of cold during the winter promotes flowering in the spring, a process termed vernalization. In Arabidopsis thaliana, the vernalization requirement of winter-annual ecotypes is caused by the MADS-box gene FLOWERING LOCUS C (FLC), which is a repressor of flowering. D...

journal_title：Genetics

authors： Reeves PA,He Y,Schmitz RJ,Amasino RM,Panella LW,Richards CM

更新日期：2007-05-01 00:00:00

abstract：:The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C(2)H(2)'s and a C(2)HC motif that a...

journal_title：Genetics

authors： Kim HR,Chae KS,Han KH,Han DM

更新日期：2009-07-01 00:00:00

abstract：:Restriction map variation in two 5-6-kb chloroplast DNA regions of five diploid Aegilops species in the section Sitopsis and two wild tetraploid wheats, Triticum dicoccoides and Triticum araraticum, was investigated with a battery of four-cutter restriction enzymes. A single accession each of Triticum durum, Triticum ...

journal_title：Genetics

authors： Miyashita NT,Mori N,Tsunewaki K

更新日期：1994-07-01 00:00:00

abstract：:Equilibria are determined for the two-locus model in a partially selfing population when one locus is neutral and the other locus is heterotic. At an equilibrium point, the frequency of heterozygotes at the neutral locus is greater than that expected from one-locus theory, even if the heterotic locus is on a different...

journal_title：Genetics

authors： Strobeck C

更新日期：1979-05-01 00:00:00

abstract：:The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...

journal_title：Genetics

authors： Hedrick PW

更新日期：1978-06-01 00:00:00

abstract：:Evolutionary models appropriate for analyzing nucleotide sequences that are subject to constraints on secondary structure are developed. The models consider the evolution of pairs of nucleotides, and they incorporate the effects of base-pairing constraints on nucleotide substitution rates by introducing a new paramete...

journal_title：Genetics

authors： Muse SV

更新日期：1995-03-01 00:00:00

abstract：:AFLP markers are becoming one of the most popular tools for genetic analysis in the fields of evolutionary genetics and ecology and conservation of genetic resources. The technique combines a high-information content and fidelity with the possibility of carrying out genomewide scans. However, a potential problem with ...

journal_title：Genetics

authors： Caballero A,Quesada H,Rolán-Alvarez E

更新日期：2008-05-01 00:00:00

abstract：:The mutation process at microsatellite loci typically occurs at high rates and with stepwise changes in allele sizes, features that may introduce bias when using classical measures of population differentiation based on allele identity (e.g., F(ST), Nei's Ds genetic distance). Allele size-based measures of differentia...

journal_title：Genetics

authors： Hardy OJ,Charbonnel N,Fréville H,Heuertz M

更新日期：2003-04-01 00:00:00

abstract：:The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1 regulates Adr1 is unkno...

journal_title：Genetics

authors： Ratnakumar S,Kacherovsky N,Arms E,Young ET

更新日期：2009-07-01 00:00:00

abstract：:The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal processes during development. In the past two decades, great progress has been made in understanding the molecular basis of axon outgrowth and guidance. Genetic analysis in Caenorhabditis elegans has played a key role in elucidating ...

journal_title：Genetics

authors： Chisholm AD,Hutter H,Jin Y,Wadsworth WG

更新日期：2016-11-01 00:00:00

abstract：:The determination of segment identity in Drosophila melanogaster appears to be controlled by a small number of genes. In order to identity new components in the process, we have systematically screened the autosomal complement for loci that show a dosage-dependent interaction with mutations in previously characterized...

journal_title：Genetics

authors： Kennison JA,Russell MA

更新日期：1987-05-01 00:00:00

abstract：:Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. Thi...

journal_title：Genetics

authors： Riley MA,Hallas ME,Lewontin RC

更新日期：1989-10-01 00:00:00

abstract：:Determining the patterns of DNA sequence variation in the human genome is a useful first step toward identifying the genetic basis of a common disease. A haplotype map (HapMap), aimed at describing these variation patterns across the entire genome, has been recently developed by the International HapMap Consortium. In...

journal_title：Genetics

authors： Liu T,Johnson JA,Casella G,Wu R

更新日期：2004-09-01 00:00:00

abstract：:The standard approaches to estimation of quantitative genetic parameters and prediction of response to selection on quantitative traits are based on theory derived for populations undergoing random mating. Many studies demonstrate, however, that mating systems in natural populations often involve inbreeding in various...

journal_title：Genetics

authors： Shaw RG,Byers DL,Shaw FH

更新日期：1998-12-01 00:00:00

abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...

journal_title：Genetics

authors： Schreck N,Piepho HP,Schlather M

更新日期：2019-10-01 00:00:00

abstract：:The rate of decline in reproductive fitness in populations of Drosophila melanogaster inbred at an initial rate of approximately 1% per generation has been investigated under both competitive and noncompetitive conditions. Breeding population size was variable in the inbred lines with an estimated harmonic mean of 66....

journal_title：Genetics

authors： Latter BD,Mulley JC,Reid D,Pascoe L

更新日期：1995-01-01 00:00:00

abstract：:A study of DNA polymorphism and divergence was conducted for the cytosolic phosphoglucose isomerase (PGI:E.C.5.3.1.9) gene of five species of the mustard genus Leavenworthia: Leavenworthia stylosa, L. alabamica, L. crassa, L. uniflora, and L. torulosa. Sequences of an internal 2.3-kb PgiC gene region spanning exons 6-...

journal_title：Genetics

authors： Filatov DA,Charlesworth D

更新日期：1999-11-01 00:00:00

abstract：:In classical "cut-and-paste" transposition, transposons are excised from donor sites and inserted at new locations. We have identified an alternative pathway in which transposition involves the 5' end of an intact Ac element and the 3' end of a nearby terminally deleted fAc (fractured Ac). The Ac and fAc elements are ...

journal_title：Genetics

authors： Zhang J,Peterson T

更新日期：2004-08-01 00:00:00

abstract：:Phosphatidylinositol catabolism in Saccharomyces cerevisiae cells cultured in media containing inositol results in the release of glycerophosphoinositol (GroPIns) into the medium. As the extracellular concentration of inositol decreases with growth, the released GroPIns is transported back into the cell. Exploiting th...

journal_title：Genetics

authors： Patton-Vogt JL,Henry SA

更新日期：1998-08-01 00:00:00

abstract：:Bacteriophage T4 cytosine-containing DNA is cleaved at a single site by the restriction endonuclease, Bam H1. The site lies within the late region of the T4 genome, close to, or within, gene 8, one of the structural genes of the phage particle baseplate. ...

journal_title：Genetics

authors： Wilson GG,Neve RL,Edlin GJ,Konigsberg WH

更新日期：1979-10-01 00:00:00

abstract：:Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...

journal_title：Genetics

authors： Seier T,Padgett DR,Zilberberg G,Sutera VA Jr,Toha N,Lovett ST

更新日期：2011-06-01 00:00:00

abstract：:We analyzed the dynamics of transposable elements (TEs) according to Wright's island and continent-island models, assuming that selection tends to counter the deleterious effects of TEs. We showed that migration between host populations has no impact on either the existence or the stability of the TE copy number equil...

journal_title：Genetics

authors： Deceliere G,Charles S,Biémont C

更新日期：2005-01-01 00:00:00