Testing for neutrality in samples with sequencing errors.

abstract：:We have identified two Saccharomyces cerevisiae genes that, in high copy, confer resistance to Kluyveromyces lactis zymocin, an inhibitor that blocks cells in the G(1) phase of the cell cycle prior to budding and DNA replication. One gene (GRX3) encodes a glutaredoxin and is likely to act at the level of zymocin entry...

journal_title：Genetics

authors： Jablonowski D,Butler AR,Fichtner L,Gardiner D,Schaffrath R,Stark MJ

更新日期：2001-12-01 00:00:00

abstract：:A total of 358 lys2 mutants of Saccharomyces cerevisiae have been characterized for suppressibility by the following suppressors: UAA and UAG suppressors that insert tyrosine, serine or leucine; a putative UGA suppressor; an omnipotent suppressor SUP46; and a frameshift suppressor SUF1-1. In addition, the lys2 mutants...

journal_title：Genetics

authors： Chattoo BB,Palmer E,Ono B,Sherman F

更新日期：1979-09-01 00:00:00

abstract：:We have investigated the order of the four genes cyc1, rad7, SUP4, and cdc8 which form a tightly linked cluster on the right arm of chromosome X in the yeast Saccharomyces cerevisiae. Crossing over and coconversion data from tetrad analysis established the gene order to be centromere-cyc1-rad7-SUP4. Also cdc8 appeared...

journal_title：Genetics

authors： Lawrence CW,Sherman F,Jackson M,Gilmore RA

更新日期：1975-12-01 00:00:00

abstract：:Distributive disjunction is defined as the first division meiotic segregation of either nonhomologous chromosomes that lack homologs or homologous chromosomes that have not recombined. To determine if chromosomes from the yeast Saccharomyces cerevisiae were capable of distributive disjunction, we constructed a strain ...

journal_title：Genetics

authors： Guacci V,Kaback DB

更新日期：1991-03-01 00:00:00

abstract：:Whereas nonlinear relationships between genes are acknowledged, there exist only a few methods for estimating nonlinear gene coexpression networks or gene regulatory networks (GCNs/GRNs) with common deficiencies. These methods often consider only pairwise associations between genes, and are, therefore, poorly capable ...

journal_title：Genetics

authors： Kontio JAJ,Rinta-Aho MJ,Sillanpää MJ

更新日期：2020-07-01 00:00:00

abstract：:Accounting for gene-environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanism...

journal_title：Genetics

authors： Zhao G,Marceau R,Zhang D,Tzeng JY

更新日期：2015-03-01 00:00:00

abstract：:C4 and CYP21 are two adjacent, but functionally unrelated genes residing in the middle of the mammalian major histocompatibility complex (Mhc). The C4 gene codes for the fourth component of the complement cascade, whereas the CYP21 gene specifies an enzyme (cytochrome P450c21) of the glucocorticoid and mineralocortico...

journal_title：Genetics

authors： Horiuchi Y,Kawaguchi H,Figueroa F,O'hUigin C,Klein J

更新日期：1993-05-01 00:00:00

abstract：:The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the ne...

journal_title：Genetics

authors： González-Barrios M,Fierro-González JC,Krpelanova E,Mora-Lorca JA,Pedrajas JR,Peñate X,Chavez S,Swoboda P,Jansen G,Miranda-Vizuete A

更新日期：2015-05-01 00:00:00

abstract：:Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and limited sample sizes. To overcome such difficulties, we used a targeted backcross...

journal_title：Genetics

authors： Sinha H,David L,Pascon RC,Clauder-Münster S,Krishnakumar S,Nguyen M,Shi G,Dean J,Davis RW,Oefner PJ,McCusker JH,Steinmetz LM

更新日期：2008-11-01 00:00:00

abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...

journal_title：Genetics

authors： Desai MM,Plotkin JB

更新日期：2008-12-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...

journal_title：Genetics

authors： Chen CZ,Calero M,DeRegis CJ,Heidtman M,Barlowe C,Collins RN

更新日期：2004-12-01 00:00:00

abstract：:This paper studies the properties of a new class of demographic parameters for age-structured populations and analyzes the effect of natural selection on these parameters. Two new demographic variables are introduced: the entropy of a population and the reproductive potential. The entropy of a population measures the ...

journal_title：Genetics

authors： Demetrius L

更新日期：1975-03-01 00:00:00

abstract：:Retrotransposons are mobile genetic elements that colonize eukaryotic genomes by replicating through an RNA intermediate. As retrotransposons can move within the host genome, defense mechanisms have evolved to repress their potential mutagenic activities. In the fission yeast Schizosaccharomyces pombe, the mRNA of Tf2...

journal_title：Genetics

authors： Mallet PL,Larochelle M,Bachand F

更新日期：2017-02-01 00:00:00

abstract：:The adaptive character of inversion polymorphism in Drosophila subobscura is well established. The O(ST) and O(3+4) chromosomal arrangements of this species differ by two overlapping inversions that arose independently on O(3) chromosomes. Nucleotide variation in eight gene regions distributed along inversion O(3) was...

journal_title：Genetics

authors： Munté A,Rozas J,Aguadé M,Segarra C

更新日期：2005-03-01 00:00:00

abstract：:The St. Thomas Hospital (STH) rabbit has been previously shown to have a Mendelian form of hypertriglyceridemia, accompanied by accelerated atherosclerosis, and these animals may serve as a useful model for human dyslipoproteinemia syndromes. Here we describe the establishment of a new colony of these STH animals, and...

journal_title：Genetics

authors： Beaty TH,Prenger VL,Virgil DG,Lewis B,Kwiterovich PO,Bachorik PS

更新日期：1992-12-01 00:00:00

abstract：:The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an impo...

journal_title：Genetics

authors： Lynn DJ,Freeman AR,Murray C,Bradley DG

更新日期：2005-07-01 00:00:00

abstract：:Evolution of a multigene family is studied from the standpoint of population genetics. It is assumed that the multigene family is undergoing continuous interchromosomal unequal crossing over, mutation and random frequency drift. The equilibrium properties of the probability of gene identity (clonality) are investigate...

journal_title：Genetics

authors： Ohta T

更新日期：1979-03-01 00:00:00

abstract：:pep5 mutants of Saccharomyces cerevisiae accumulate inactive precursors to the vacuolar hydrolases. The PEP5 gene was isolated from a genomic DNA library by complementation of the pep5-8 mutation. Deletion analysis localized the complementing activity to a 3.3-kb DNA fragment. DNA sequence analysis of the PEP5 gene re...

journal_title：Genetics

authors： Woolford CA,Dixon CK,Manolson MF,Wright R,Jones EW

更新日期：1990-08-01 00:00:00

abstract：:Drosophila melanogaster males dosage compensate by twofold upregulation of the expression of genes on their single X chromosome. This process requires at least five proteins and two noncoding RNAs, roX1 and roX2, which paint the male X chromosome. We used a deletion analysis to search for functional RNA domains within...

journal_title：Genetics

authors： Stuckenholz C,Meller VH,Kuroda MI

更新日期：2003-07-01 00:00:00

abstract：:Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the ...

journal_title：Genetics

authors： Yi N,Banerjee S,Pomp D,Yandell BS

更新日期：2007-07-01 00:00:00

abstract：:Many heterogametic organisms adjust sex chromosome expression to accommodate differences in gene dosage. This requires selective recruitment of regulatory factors to the modulated chromosome. How these factors are localized to a chromosome with requisite accuracy is poorly understood. Drosophila melanogaster males inc...

journal_title：Genetics

authors： Deshpande N,Meller VH

更新日期：2018-08-01 00:00:00

abstract：:The recent progress in sequencing technologies makes possible large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The results of such efforts depend heavily on the use of efficient study designs and analytical methods. We introduce here a unified framework for associat...

journal_title：Genetics

authors： Ionita-Laza I,Ottman R

更新日期：2011-11-01 00:00:00

abstract：:Ribosome biogenesis requires at least 18 putative ATP-dependent RNA helicases in Saccharomyces cerevisiae. To explore the functional environment of one of these putative RNA helicases, Dbp6p, we have performed a synthetic lethal screen with dbp6 alleles. We have previously characterized the nonessential Rsa1p, whose n...

journal_title：Genetics

authors： de la Cruz J,Lacombe T,Deloche O,Linder P,Kressler D

更新日期：2004-04-01 00:00:00

abstract：:The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic con...

journal_title：Genetics

authors： Emmerich J,Meyer CA,de la Cruz AF,Edgar BA,Lehner CF

更新日期：2004-10-01 00:00:00

abstract：:Adaptive dynamics formalism demonstrates that, in a constant environment, a continuous trait may first converge to a singular point followed by spontaneous transition from a unimodal trait distribution into a bimodal one, which is called "evolutionary branching." Most previous analyses of evolutionary branching have b...

journal_title：Genetics

authors： Wakano JY,Iwasa Y

更新日期：2013-01-01 00:00:00

abstract：:Availability of animal protein for human consumption is very low in the developing countries mainly because of low productivity of existing livestock; ways and means to improve productivity through breeding are discussed and some basic issues requiring further research pointed out. ...

journal_title：Genetics

authors： Rendel J

更新日期：1974-09-01 00:00:00

abstract：:Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...

journal_title：Genetics

authors： Grognet P,Bidard F,Kuchly C,Tong LC,Coppin E,Benkhali JA,Couloux A,Wincker P,Debuchy R,Silar P

更新日期：2014-05-01 00:00:00

abstract：:We describe a method for co-estimating r = C/mu (where C is the per-site recombination rate and mu is the per-site neutral mutation rate) and Theta = 4N(e)mu (where N(e) is the effective population size) from a population sample of molecular data. The technique is Metropolis-Hastings sampling: we explore a large numbe...

journal_title：Genetics

authors： Kuhner MK,Yamato J,Felsenstein J

更新日期：2000-11-01 00:00:00

abstract：:The infinite-sites model with no recombination is extended to include mutations that affect electrophoretic mobility. The model allows the effect of a single-site mutation to have a continuous effect on mobility. Formulae are obtained for the variance of electrophoretic mobility of alleles after an arbitrary lenght of...

journal_title：Genetics

authors： Cobbs G

更新日期：1979-06-01 00:00:00