Assessing gene-environment interactions for common and rare variants with binary traits using gene-trait similarity regression.

abstract：:Associative overdominance, the fitness difference between heterozygotes and homozygotes at a neutral locus, is classically described using two categories of models: linkage disequilibrium in small populations or identity disequilibrium in infinite, partially selfing populations. In both cases, only equilibrium situati...

journal_title：Genetics

authors： Bierne N,Tsitrone A,David P

更新日期：2000-08-01 00:00:00

abstract：:Wright's method of estimating the number of genes contributing to the difference in a quantitative character between two populations involves observing the means and variances of the two parental populations and their hybrid populations. Although simple, Wright's method provides seriously biased estimates, largely due...

journal_title：Genetics

authors： Zeng ZB

更新日期：1992-08-01 00:00:00

abstract：:Gene targeting using sequence insertion vectors generally results in integration of one copy of the targeting vector generating a tandem duplication of the cognate chromosomal region of homology. However, occasionally the target locus is found to contain >1 copy of the integrated vector. The mechanism by which the lat...

journal_title：Genetics

authors： Ng P,Baker MD

更新日期：1999-03-01 00:00:00

abstract：:Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...

journal_title：Genetics

authors： Chithambaram S,Prabhakaran R,Xia X

更新日期：2014-05-01 00:00:00

abstract：:Levels of genetic variation and linkage disequilibrium (LD) are critical factors in association mapping methods as well as in identification of loci that have been targets of selection. Maize, an outcrosser, has a high level of sequence variation and a limited extent of LD. Sorghum, a closely related but largely self-...

journal_title：Genetics

authors： Hamblin MT,Mitchell SE,White GM,Gallego J,Kukatla R,Wing RA,Paterson AH,Kresovich S

更新日期：2004-05-01 00:00:00

abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...

journal_title：Genetics

authors： Schreck N,Piepho HP,Schlather M

更新日期：2019-10-01 00:00:00

abstract：:In plants, many major regulatory genes that control plant growth and development have been identified and characterized. Despite a detailed knowledge of the function of these genes little is known about how they contribute to the natural variation for complex traits. To determine whether major regulatory genes of maiz...

journal_title：Genetics

authors： Weber A,Clark RM,Vaughn L,Sánchez-Gonzalez Jde J,Yu J,Yandell BS,Bradbury P,Doebley J

更新日期：2007-12-01 00:00:00

abstract：:The progeny of crosses between wild-type strains of Phycomyces usually do not exhibit all of the expected genotypes from meiosis. By backcrossing, we have isolated a new (+) mating-type strain, A56, which is nearly isogenic with the (-) wild-type NRRL1555 commonly used in Phycomyces research. Tetrad analysis of the ba...

journal_title：Genetics

authors： Alvarez MI,Eslava AP

更新日期：1983-12-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...

journal_title：Genetics

authors： Malavazi I,Lima JF,de Castro PA,Savoldi M,de Souza Goldman MH,Goldman GH

更新日期：2008-02-01 00:00:00

abstract：:Obtaining accurate estimates of the genetic covariance matrix Sigma(G) for multivariate data is a fundamental task in quantitative genetics and important for both evolutionary biologists and plant or animal breeders. Classical methods for estimating Sigma(G) are well known to suffer from substantial sampling errors; i...

journal_title：Genetics

authors： Meyer K,Kirkpatrick M

更新日期：2010-07-01 00:00:00

abstract：:l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional misexpression of the gene associated with this mutation as well as with several euchromatic insertions of l(3)S12+ transposons. S...

journal_title：Genetics

authors： Dutton FL Jr,Chovnick A

更新日期：1991-05-01 00:00:00

abstract：:The Saccharomyces cerevisiae GAL/MEL regulon genes are normally induced within minutes of galactose addition, but gal3 mutants exhibit a 3-5-day induction lag. We have discovered that this long-term adaptation (LTA) phenotype conferred by gal3 is complemented by multiple copies of the GAL1 gene. Based on this result a...

journal_title：Genetics

authors： Bhat PJ,Oh D,Hopper JE

更新日期：1990-06-01 00:00:00

abstract：:Recombination and chromosome synapsis bring homologous chromosomes together, creating chiasmata that ensure accurate disjunction during reductional division. SPO13 is a key gene required for meiosis I (MI) reductional segregation, but dispensable for recombination, in Saccharomyces cerevisiae. Absence of SPO13 leads t...

journal_title：Genetics

authors： Rutkowski LH,Esposito RE

更新日期：2000-08-01 00:00:00

abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...

journal_title：Genetics

authors： Norris AD,Kim HM,Colaiácovo MP,Calarco JA

更新日期：2015-10-01 00:00:00

abstract：:Genome-wide association studies have identified thousands of variants implicated in dozens of complex diseases. Most studies collect individuals with and without disease and search for variants with different frequencies between the groups. For many of these studies, additional disease traits are also collected. Joint...

journal_title：Genetics

authors： Bilow M,Crespo F,Pan Z,Eskin E,Eyheramendy S

更新日期：2017-03-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:Two strains of Drosophila melanogaster derived from different geographical localities were subjected to selection for fast and slow developmental rate. Four enzyme polymorphisms were monitored for their response to such selection. Significant changes in allele frequencies were effected for the alphaGpdh and 6Pgd polym...

journal_title：Genetics

authors： Cavener DR

更新日期：1983-09-01 00:00:00

abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...

journal_title：Genetics

authors： Cherry JL

更新日期：2004-02-01 00:00:00

abstract：:The idealized individual in many fungal species is a haploid self-sterile hermaphrodite that may be propagated by asexually produced spores or that may reproduce sexually. In field populations, polymorphism occurs for female-sterile/hermaphrodite status, and female-sterile mutants, which function only as males during ...

journal_title：Genetics

authors： Leslie JF,Klein KK

更新日期：1996-10-01 00:00:00

abstract：:Filamentous fungi undergo cytokinesis by forming crosswalls termed septa. Here, we describe the genetic and physiological controls governing septation in Aspergillus nidulans. Germinating conidia do not form septa until the completion of their third nuclear division. The first septum is invariantly positioned at the b...

journal_title：Genetics

authors： Harris SD,Morrell JL,Hamer JE

更新日期：1994-02-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of the mitochondrial DNA (mtDNA) of the dogfish, Scyliorhinus canicula. The 16,697-bp-long mtDNA possesses a gene organization identical to that of the Osteichthyes, but different from that of the sea lamprey Petromyzon marinus. The main features of the mtDNA of oste...

journal_title：Genetics

authors： Delarbre C,Spruyt N,Delmarre C,Gallut C,Barriel V,Janvier P,Laudet V,Gachelin G

更新日期：1998-09-01 00:00:00

abstract：:Thirteen of 14 temperature-sensitive mutants deficient in successive steps of mitotic chromosome transmission (cdc2, 4, 5, 6, 7, 8, 9, 13, 14, 15, 16, 17 and 20) from spindle pole body separation to a late stage of nuclear division exhibited a dramatic increase in the frequency of chromosome loss and/or mitotic recomb...

journal_title：Genetics

authors： Hartwell LH,Smith D

更新日期：1985-07-01 00:00:00

abstract：:Hybridization between related species results in the formation of an allopolyploid with multiple subgenomes. These subgenomes will each contain complete, yet evolutionarily divergent, sets of genes. Like a diploid hybrid, allopolyploids will have two versions, or homeoalleles, for every gene. Partial functional redund...

journal_title：Genetics

authors： Santantonio N,Jannink JL,Sorrells M

更新日期：2019-03-01 00:00:00

abstract：:Restriction site-associated DNA sequencing or genotyping-by-sequencing (GBS) approaches allow for rapid and cost-effective discovery and genotyping of thousands of single-nucleotide polymorphisms (SNPs) in multiple individuals. However, rigorous quality control practices are needed to avoid high levels of error and bi...

journal_title：Genetics

authors： Chen N,Van Hout CV,Gottipati S,Clark AG

更新日期：2014-11-01 00:00:00

abstract：:A study of DNA polymorphism and divergence was conducted for the cytosolic phosphoglucose isomerase (PGI:E.C.5.3.1.9) gene of five species of the mustard genus Leavenworthia: Leavenworthia stylosa, L. alabamica, L. crassa, L. uniflora, and L. torulosa. Sequences of an internal 2.3-kb PgiC gene region spanning exons 6-...

journal_title：Genetics

authors： Filatov DA,Charlesworth D

更新日期：1999-11-01 00:00:00

abstract：:The Genetics Society of America (GSA) Medal recognizes researchers who have made outstanding contributions to the field of genetics in the past 15 years. The 2019 GSA Medal is awarded to Bonnie L. Bassler of Princeton University and the Howard Hughes Medical Institute in recognition of her groundbreaking studies of ba...

journal_title：Genetics

authors： Bassler BL

更新日期：2020-06-01 00:00:00

abstract：:Predictions for the rate of inbreeding (DeltaF) in populations with discrete generations undergoing selection on best linear unbiased prediction (BLUP) of breeding value were developed. Predictions were based on the concept of long-term genetic contributions using a recently established relationship between expected c...

journal_title：Genetics

authors： Bijma P,Woolliams JA

更新日期：2000-09-01 00:00:00

abstract：:In vivo haploid induction (HI) triggered by pollination with special intraspecific genotypes, called inducers, is unique to Zea maysL. within the plant kingdom and has revolutionized maize breeding during the last decade. However, the molecular mechanisms underlying HI in maize are still unclear. To investigate the ge...

journal_title：Genetics

authors： Hu H,Schrag TA,Peis R,Unterseer S,Schipprack W,Chen S,Lai J,Yan J,Prasanna BM,Nair SK,Chaikam V,Rotarenco V,Shatskaya OA,Zavalishina A,Scholten S,Schön CC,Melchinger AE

更新日期：2016-04-01 00:00:00

abstract：:The forest tent caterpillar is polymorphic for two melanic genes affecting wing color of moths. These are the first genetically determined morphological traits reported for the genus. Dark (D) is a sex-limited, autosomal dominant with a phenotype of dark brown males. Frequencies in population samples varied from 8 to ...

journal_title：Genetics

authors： Lorimer N

更新日期：1979-06-01 00:00:00

abstract：:Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from Drosophila to humans. Here, we...

journal_title：Genetics

authors： Nagarkar S,Wasnik R,Govada P,Cohen S,Shashidhara LS

更新日期：2020-09-01 00:00:00