The complete nucleotide sequence of the mitochondrial DNA of the dogfish, Scyliorhinus canicula.

abstract：:Fifteen classical linkage groups were identified in two salmonid species (Salmo trutta and Salmo gairdneri) and three fertile, interspecific hybrids (S. gairdneri X Salmo clarki, Salvelinus fontinalis X Salvelinus namaycush and S. fontinalis X Salvelinus alpinus) by backcrossing multiply heterozygous individuals. Thes...

journal_title：Genetics

authors： Johnson KR,Wright JE Jr,May B

更新日期：1987-08-01 00:00:00

abstract：:I report a framework for assessing whether one mitochondrial genome is significantly more rearranged than another. This relative rate of gene rearrangement test (RGR) behaves according to expectation, distinguishing between highly rearranged and mildly rearranged insect mitochondrial genomes. It may be more broadly ap...

journal_title：Genetics

authors： Dowton M

更新日期：2004-06-01 00:00:00

abstract：:Significant amounts of apoptosis take place during Drosophila development. The proapoptotic genes reaper (rpr), grim, and head involution defective (hid) are required for virtually all embryonic apoptosis. The proteins encoded by these genes share a short region of homology at their amino termini. The Drosophila IAP h...

journal_title：Genetics

authors： Lisi S,Mazzon I,White K

更新日期：2000-02-01 00:00:00

abstract：:According to theory, F(2) hybrid breakdown (lethality or sterility) is due to incompatibilities between interacting genes of the different species (i.e., the breaking up of coadapted gene complexes). Detection of such incompatibilities is particularly straightforward in haplodiploid species, because virgin F(1) hybrid...

journal_title：Genetics

authors： Gadau J,Page RE Jr,Werren JH

更新日期：1999-12-01 00:00:00

abstract：:Metazoan genomes encode an abundant collection of mRNA-like, long noncoding (lnc)RNAs. Although lncRNAs greatly expand the transcriptional repertoire, we have a limited understanding of how these RNAs contribute to developmental regulation. Here, we investigate the function of the Drosophila lncRNA called yellow-achae...

journal_title：Genetics

authors： Soshnev AA,Ishimoto H,McAllister BF,Li X,Wehling MD,Kitamoto T,Geyer PK

更新日期：2011-10-01 00:00:00

abstract：:Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (...

journal_title：Genetics

authors： Funkhouser SA,Vazquez AI,Steibel JP,Ernst CW,Los Campos G

更新日期：2020-05-01 00:00:00

abstract：:For more than 60 years, evolutionary cytogeneticists have been using naturally occurring chromosomal inversions to infer phylogenetic histories, especially in insects with polytene chromosomes. The validity of this method is predicated on the assumption that inversions arise only once in the history of a lineage, so t...

journal_title：Genetics

authors： Caccone A,Min GS,Powell JR

更新日期：1998-10-01 00:00:00

abstract：:The homozygosity of a population will be influenced by any recent change in the population size. The "homozygosity test" of the neutral mutation hypothesis might also be influenced by a population change. A computer simulation method is described that establishes the significance levels of observed homozygosities afte...

journal_title：Genetics

authors： Watterson GA

更新日期：1986-04-01 00:00:00

abstract：:In Drosophila melanogaster, heterochromatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insights into the properties of heterochromatin. Class I modifiers suppress PEV, and class II modifiers enhance PEV when the modifier gene is present in fewer than two doses. We have exami...

journal_title：Genetics

authors： Sass GL,Henikoff S

更新日期：1998-02-01 00:00:00

abstract：:Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...

journal_title：Genetics

authors： Ellis LL,Carney GE

更新日期：2011-01-01 00:00:00

abstract：:Presynaptic association of homologous chromosomes is a prerequisite to the sequence of events that lead to chiasma formation. This association of homologous chromosomes, as entire units, occurs with probability a, and chiasma formation occurs independently in opposite chromosome arms with probability c. a and c have b...

journal_title：Genetics

authors： Driscoll CJ,Bielig LM,Darvey NL

更新日期：1979-04-01 00:00:00

abstract：:Transvection is the phenomenon where a transcriptional enhancer activates a promoter located on the homologous chromosome. It has been amply documented in Drosophila where homologs are closely paired in most, if not all, somatic nuclei, but it has been known to rarely occur in mammals as well. We have taken advantage ...

journal_title：Genetics

authors： Piwko P,Vitsaki I,Livadaras I,Delidakis C

更新日期：2019-06-01 00:00:00

abstract：:Trans-species polymorphism, meaning the presence of alleles in different species that are more similar to each other than they are to alleles in the same species, has been found at loci associated with vegetative incompatibility in filamentous fungi. If individuals differ at one or more of these loci (termed het for h...

journal_title：Genetics

authors： Muirhead CA,Glass NL,Slatkin M

更新日期：2002-06-01 00:00:00

abstract：:The vertebrate limb serves as an experimental paradigm to study mechanisms that regulate development of the stereotypical skeletal elements. In this study, we simultaneously inactivated Sall4 using Hoxb6Cre and Plzf in mouse embryos, and found that their combined function regulates development of the proximal-anterior...

journal_title：Genetics

authors： Chen KQ,Tahara N,Anderson A,Kawakami H,Kawakami S,Nishinakamura R,Pandolfi PP,Kawakami Y

更新日期：2020-05-01 00:00:00

abstract：:The purpose of this study was to characterize two mutator stocks of yeast which were induced and selected on the basis of high spontaneous reversion rates of the suppressible "ochre" nonsense allele lys1-1. In the mutator stock VA-3, a single mutation, designated mut1-1, is responsible for the increase in the reversio...

journal_title：Genetics

authors： Gottlieb DJ,von Borstel RC

更新日期：1976-08-01 00:00:00

abstract：:Although most living organisms reproduce sexually, some have developed a uniparental reproduction where the embryo usually derives from the female parent. A unique case of paternal apomixis in plants has been recently reported in Cupressus dupreziana, an endangered Mediterranean conifer. This species produces unreduce...

journal_title：Genetics

authors： Pichot C,Liens B,Nava JL,Bachelier JB,El Maâtaoui M

更新日期：2008-01-01 00:00:00

abstract：:Accounting for gene-environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanism...

journal_title：Genetics

authors： Zhao G,Marceau R,Zhang D,Tzeng JY

更新日期：2015-03-01 00:00:00

abstract：:The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include ...

journal_title：Genetics

authors： Motro U,Thomson G

更新日期：1985-07-01 00:00:00

abstract：:Genomic integrity is threatened by multiple sources of DNA damage. DNA double-strand breaks (DSBs) are among the most dangerous types of DNA lesions and can be generated by endogenous or exogenous agents, but they can arise also during DNA replication. Sister chromatid recombination (SCR) is a key mechanism for the re...

journal_title：Genetics

authors： Conde F,Refolio E,Cordón-Preciado V,Cortés-Ledesma F,Aragón L,Aguilera A,San-Segundo PA

更新日期：2009-06-01 00:00:00

abstract：:Fisher's geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic traits, it provides a simple mechanism for the emergence of genotypic epistasis from...

journal_title：Genetics

authors： Hwang S,Park SC,Krug J

更新日期：2017-06-01 00:00:00

abstract：:Low-coverage next-generation sequencing methodologies are routinely employed to genotype large populations. Missing data in these populations manifest both as missing markers and markers with incomplete allele recovery. False homozygous calls at heterozygous sites resulting from incomplete allele recovery confound man...

journal_title：Genetics

authors： Fragoso CA,Heffelfinger C,Zhao H,Dellaporta SL

更新日期：2016-02-01 00:00:00

abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...

journal_title：Genetics

authors： Goldstein B,Nance J

更新日期：2020-02-01 00:00:00

abstract：:Yeast DNA fragments that confer multiple drug resistance when amplified were isolated. Cells containing a yeast genomic library cloned in the high copy autonomously replicating vector, YEp24, were plated on medium containing cycloheximide. Five out of 100 cycloheximide-resistant colonies were cross-resistant to the un...

journal_title：Genetics

authors： Leppert G,McDevitt R,Falco SC,Van Dyk TK,Ficke MB,Golin J

更新日期：1990-05-01 00:00:00

abstract：:To understand the role of Los1p in pre-tRNA splicing, we sought los1 multicopy suppressors. We found SOL1 that suppresses both point and null LOS1 mutations. Since, when fused to the Ga14p DNA-binding domain, Los1p activates transcription, we tested whether Los1p regulates SOL1. We found that las1 mutants have deplete...

journal_title：Genetics

authors： Shen WC,Stanford DR,Hopper AK

更新日期：1996-06-01 00:00:00

abstract：:The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmen...

journal_title：Genetics

authors： Lukas L,Kuzminov A

更新日期：2006-02-01 00:00:00

abstract：:Currently used tests of Hardy-Weinberg proportions do not take into account the nature of the alternative hypothesis, which is generally a heterozygote deficiency. Different exact tests, appropriate for small sample size and large number of alleles, are proposed in this perspective, and their properties are evaluated ...

journal_title：Genetics

authors： Rousset F,Raymond M

更新日期：1995-08-01 00:00:00

abstract：:Age-specific effects of spontaneous mutations on mortality rates in Drosophila are inferred from three large demographic experiments. Data were collected from inbred lines that were allowed to accumulate spontaneous mutations for 10, 19, and 47 generations. Estimates of age-specific mutational variance for mortality w...

journal_title：Genetics

authors： Pletcher SD,Houle D,Curtsinger JW

更新日期：1999-10-01 00:00:00

abstract：:Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...

journal_title：Genetics

authors： Saitoh K,Onishi K,Mikami I,Thidar K,Sano Y

更新日期：2004-10-01 00:00:00

abstract：:A total of 568 new simple sequence repeat (SSR)-based markers for barley have been developed from a combination of database sequences and small insert genomic libraries enriched for a range of short simple sequence repeats. Analysis of the SSRs on 16 barley cultivars revealed variable levels of informativeness but no ...

journal_title：Genetics

authors： Ramsay L,Macaulay M,degli Ivanissevich S,MacLean K,Cardle L,Fuller J,Edwards KJ,Tuvesson S,Morgante M,Massari A,Maestri E,Marmiroli N,Sjakste T,Ganal M,Powell W,Waugh R

更新日期：2000-12-01 00:00:00

abstract：:The rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage th...

journal_title：Genetics

authors： Xia X

更新日期：1996-11-01 00:00:00