Abstract：
:The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic consequences of null mutations in Cyclin D, the single D-type cyclin gene in Drosophila. As previously observed with null mutations in the single Drosophila Cdk4 gene, these mutations do not primarily affect progression through the G1 phase. Moreover, the apparently indistinguishable phenotypes of double (CycD and Cdk4) and single mutants (CycD or Cdk4) argue against major independent functions of Cyclin D and Cdk4. The reduced cellular and organismal growth rates observed in both mutants indicate that Cyclin D-Cdk4 acts as a growth driver.
journal_name
Geneticsjournal_title
Geneticsauthors
Emmerich J,Meyer CA,de la Cruz AF,Edgar BA,Lehner CFdoi
10.1534/genetics.104.027417keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
867-75issue
2eissn
0016-6731issn
1943-2631pii
168/2/867journal_volume
168pub_type
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