Sex chromosome meiotic drive in stalk-eyed flies.

abstract：:OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for identifying conserved genes for research into biological and disease mechanisms. However, the efficacy of orthology prediction depends on th...

journal_title：Genetics

authors： Kim W,Underwood RS,Greenwald I,Shaye DD

更新日期：2018-10-01 00:00:00

abstract：:We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., less tha...

journal_title：Genetics

authors： Marsh JL,Wright TR

更新日期：1986-02-01 00:00:00

abstract：:Loss or gain of whole chromosomes, or parts of chromosomes, is found in various pathological conditions, such as cancer and aneuploidy, and results from the missegregation of chromosomes during cellular division or abnormal mitotic recombination. We introduce a novel strategy for determining the consequences of segmen...

journal_title：Genetics

authors： Duchon A,Besson V,Pereira PL,Magnol L,Hérault Y

更新日期：2008-09-01 00:00:00

abstract：:A supposed sporulation-deficient mutation of Saccharomyces cerevisiae is found to affect mating in haploids and in diploids, and to be inseparable from the mating-type locus by recombination. The mutation is regarded as a defective a allele and is designated a*. This is confirmed by its dominance relations in diploids...

journal_title：Genetics

authors： Kassir Y,Simchen G

更新日期：1976-02-01 00:00:00

abstract：:We demonstrate the involvement of suppressor of meiotic silencing-2 (sms-2(+)), a Neurospora gene coding for an Argonaute-like protein, in meiotic silencing and normal sexual development. ...

journal_title：Genetics

authors： Lee DW,Pratt RJ,McLaughlin M,Aramayo R

更新日期：2003-06-01 00:00:00

abstract：:Tetrahymena is a useful eukaryotic model for biochemistry and molecular cell biology studies. We previously demonstrated that targeted ectopic DNA elimination, also called co-Deletion (coDel), can be induced by the introduction of an internal eliminated sequence (IES)-target DNA chimeric construct. In this study, we d...

journal_title：Genetics

authors： Hayashi A,Mochizuki K

更新日期：2015-09-01 00:00:00

abstract：:During segmentation of vertebrate embryos, somites form in accordance with a periodic pattern established by the segmentation clock. In the zebrafish (Danio rerio), the segmentation clock includes six hairy/enhancer of split-related (her/hes) genes, five of which oscillate due to negative autofeedback. The nonoscillat...

journal_title：Genetics

authors： Schwendinger-Schreck J,Kang Y,Holley SA

更新日期：2014-06-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:Highly specialized obligatory cave beetles endemic to the French Pyrenees offer an opportunity to investigate the relative importance of environmental conditions and ecological characteristics on the organization of genetic variability, to describe the genetic structure of populations, and to assess the extent of gene...

journal_title：Genetics

authors： Crouau-Roy B

更新日期：1989-03-01 00:00:00

abstract：:The Genetics Society of America (GSA) Medal recognizes researchers who have made outstanding contributions to the field of genetics in the past 15 years. The 2019 GSA Medal is awarded to Bonnie L. Bassler of Princeton University and the Howard Hughes Medical Institute in recognition of her groundbreaking studies of ba...

journal_title：Genetics

authors： Bassler BL

更新日期：2020-06-01 00:00:00

abstract：:Boundaries (insulators) in the Drosophila bithorax complex (BX-C) delimit autonomous regulatory domains that orchestrate the parasegment (PS)-specific expression of the BX-C homeotic genes. The Fab-7 boundary separates the iab-6 and iab-7 regulatory domains, which control Abd-B expression in PS11 and PS12, respectivel...

journal_title：Genetics

authors： Fedotova A,Aoki T,Rossier M,Mishra RK,Clendinen C,Kyrchanova O,Wolle D,Bonchuk A,Maeda RK,Mutero A,Cleard F,Mogila V,Karch F,Georgiev P,Schedl P

更新日期：2018-10-01 00:00:00

abstract：:Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...

journal_title：Genetics

authors： Ellis LL,Carney GE

更新日期：2011-01-01 00:00:00

abstract：:Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...

journal_title：Genetics

authors： Chen CZ,Calero M,DeRegis CJ,Heidtman M,Barlowe C,Collins RN

更新日期：2004-12-01 00:00:00

abstract：:The sex-ratio trait described in several Drosophila species is a type of naturally occurring X-linked meiotic drive that causes males bearing a sex-ratio X chromosome to produce progenies with a large excess of females. We have previously reported the occurrence of sex-ratio X chromosomes in Drosophila simulans. In th...

journal_title：Genetics

authors： Cazemajor M,Landré C,Montchamp-Moreau C

更新日期：1997-10-01 00:00:00

abstract：:Seventeen lines, each homozygous for a different X chromosome but all with a common autosomal genetic blackground, were constructed and assayed for abdominal bristle number to determine whether dosage compensation operates for sex-linked genes affecting this character. --The regression coefficient of male mean on fema...

journal_title：Genetics

authors： Frankham R

更新日期：1977-01-01 00:00:00

abstract：:The contribution of epigenetic alterations to natural variation for gene transcription levels remains unclear. In this study, we investigated the functional targets of the maize chromomethylase ZMET2 in multiple inbred lines to determine whether epigenetic changes conditioned by this chromomethylase are conserved or v...

journal_title：Genetics

authors： Makarevitch I,Stupar RM,Iniguez AL,Haun WJ,Barbazuk WB,Kaeppler SM,Springer NM

更新日期：2007-10-01 00:00:00

abstract：:In Arabidopsis thaliana, significant efforts to determine the extent of genomic variation between phenotypically divergent accessions are under way, but virtually nothing is known about variation at the transcription level. We used microarrays to examine variation in transcript abundance among three inbred lines and t...

journal_title：Genetics

authors： Vuylsteke M,van Eeuwijk F,Van Hummelen P,Kuiper M,Zabeau M

更新日期：2005-11-01 00:00:00

abstract：:Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "parti...

journal_title：Genetics

authors： Thomas-Orillard M,Jeune B,Cusset G

更新日期：1995-08-01 00:00:00

abstract：:The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation in natural populations that is deleterious and destined to be eliminated and the fraction of fixed differences between species ...

journal_title：Genetics

authors： Fay JC,Wyckoff GJ,Wu CI

更新日期：2001-07-01 00:00:00

abstract：:Our previous work suggests that the Nhp6 HMGB protein stimulates RNA polymerase II transcription via the TATA-binding protein TBP and that Nhp6 functions in the same functional pathway as the Gcn5 histone acetyltransferase. In this report we examine the genetic relationship between Nhp6 and Gcn5 with the Mot1 and Ccr4...

journal_title：Genetics

authors： Biswas D,Yu Y,Mitra D,Stillman DJ

更新日期：2006-02-01 00:00:00

abstract：:In order to define more precisely the most proximal portion of chromosome 3R in Drosophila melanogaster, several new chromosome aberrations involving this region have been recovered and analyzed. These new arrangements were recovered as induced reversions of two dominant mutations, ANTPNs and dsxD, located in the regi...

journal_title：Genetics

authors： Duncan IW,Kaufman TC

更新日期：1975-08-01 00:00:00

abstract：:The spindle assembly checkpoint-mediated mitotic arrest depends on proteins that signal the presence of one or more unattached kinetochores and prevents the onset of anaphase in the presence of kinetochore or spindle damage. In the presence of either damage, bub2 cells initiate a preanaphase delay but do not maintain ...

journal_title：Genetics

authors： Krishnan R,Pangilinan F,Lee C,Spencer F

更新日期：2000-10-01 00:00:00

abstract：:A system for genetic analysis in the cellular slime mold P. violaceum has been developed. Two growth-temperature-sensitive mutants were isolated in a haploid strain and used to select rare diploid heterozygotes arising by spontaneous fusion of the haploid cells. A recessive mutation to cycloheximide resistance in one ...

journal_title：Genetics

authors： Warren AJ,Warren WD,Cox EC

更新日期：1976-05-01 00:00:00

abstract：:Genome stability in fission yeast requires the conserved S-phase kinase Hsk1 (Cdc7) and its partner Dfp1 (Dbf4). In addition to their established function in the initiation of DNA replication, we show that these proteins are important in maintaining genome integrity later in S phase and G2. hsk1 cells suffer increased...

journal_title：Genetics

authors： Dolan WP,Le AH,Schmidt H,Yuan JP,Green M,Forsburg SL

更新日期：2010-05-01 00:00:00

abstract：:Transposable elements (TEs) constitute a substantial fraction of the eukaryotic genome and, as a result, have a complex relationship with their host that is both adversarial and dependent. To minimize damage to cellular genes, TEs possess mechanisms that target integration to sequences of low importance. However, the ...

journal_title：Genetics

authors： Hickey A,Esnault C,Majumdar A,Chatterjee AG,Iben JR,McQueen PG,Yang AX,Mizuguchi T,Grewal SI,Levin HL

更新日期：2015-11-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...

journal_title：Genetics

authors： Pan W,Kim J,Zhang Y,Shen X,Wei P

更新日期：2014-08-01 00:00:00

abstract：:Frequent nonhomologous recombination has been previously postulated to explain the 1045-bp insertion in one mitochondrial sperm-transmitted haplotype of Mytilus galloprovincialis. Such recombination would lead to the disruption of gene order and so the existence of a specific mechanism for maintaining the same gene or...

journal_title：Genetics

authors： Burzyński A

更新日期：2007-02-01 00:00:00

abstract：:We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication. The family includes S. cerevisiae proteins Rad2p and its human homolog XPGC, Rad27p and its mammalian homolog FEN-1, and Exonuclea...

journal_title：Genetics

authors： Fikus MU,Mieczkowski PA,Koprowski P,Rytka J,Sledziewska-Gójska E,Ciésla Z

更新日期：2000-01-01 00:00:00

abstract：:The sojourn times until fixation of an overdominant allele were investigated based on the diffusion equation. Furthermore, the rate of accumulation of mutations, or the substitution rate, was predicted from the mean extinction time of a common overdominant allele. The substitution rate calculated theoretically agreed ...

journal_title：Genetics

authors： Ohashi J,Tokunaga K

更新日期：2000-06-01 00:00:00