Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right arm.

abstract：:The nuclear aod-1 gene of Neurospora crassa encodes the alternative oxidase and is induced when the standard cytochrome-mediated respiratory chain of mitochondria is inhibited. To study elements of the pathway responsible for alternative oxidase induction, we generated a series of mutations in the region upstream from...

journal_title：Genetics

authors： Chae MS,Lin CC,Kessler KE,Nargang CE,Tanton LL,Hahn LB,Nargang FE

更新日期：2007-04-01 00:00:00

abstract：:The RPS5 disease resistance gene of Arabidopsis mediates recognition of Pseudomonas syringae strains that possess the avirulence gene avrPphB. By screening for loss of RPS5-specified resistance, we identified five pbs (avrPphB susceptible) mutants that represent three different genes. Mutations in PBS1 completely bloc...

journal_title：Genetics

authors： Warren RF,Merritt PM,Holub E,Innes RW

更新日期：1999-05-01 00:00:00

abstract：:Biofilms are microbial communities that form on surfaces. They are the primary form of microbial growth in nature and can have detrimental impacts on human health. Some strains of the budding yeast Saccharomyces cerevisiae form colony biofilms, and there is substantial variation in colony architecture between biofilm-...

journal_title：Genetics

authors： Granek JA,Murray D,Kayrkçi Ö,Magwene PM

更新日期：2013-02-01 00:00:00

abstract：:An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, cre...

journal_title：Genetics

authors： Bui DT,Friedrich A,Al-Sweel N,Liti G,Schacherer J,Aquadro CF,Alani E

更新日期：2017-04-01 00:00:00

abstract：:We have examined the stability of duplicated DNA sequences in the sexual phase of the life cycle of the basidiomycete fungus, Coprinus cinereus. We observed premeiotic de novo methylation in haploid nuclei containing either a triplication, a tandem duplication, or an ectopic duplication. Methylation changes were not o...

journal_title：Genetics

authors： Freedman T,Pukkila PJ

更新日期：1993-10-01 00:00:00

abstract：:Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect in...

journal_title：Genetics

authors： Kruijer W

更新日期：2016-01-01 00:00:00

abstract：:Determining the patterns of DNA sequence variation in the human genome is a useful first step toward identifying the genetic basis of a common disease. A haplotype map (HapMap), aimed at describing these variation patterns across the entire genome, has been recently developed by the International HapMap Consortium. In...

journal_title：Genetics

authors： Liu T,Johnson JA,Casella G,Wu R

更新日期：2004-09-01 00:00:00

abstract：:Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the ...

journal_title：Genetics

authors： Yi N,Banerjee S,Pomp D,Yandell BS

更新日期：2007-07-01 00:00:00

abstract：:Using an insertional mutagenesis approach, a series of Neurospora crassa mutants affected in the ability to control entry into the conidiation developmental program were isolated. One such mutant, GTH16-T4, was found to lack normal vegetative hyphae and to undergo constitutive conidiation. The affected gene has been n...

journal_title：Genetics

authors： Kothe GO,Free SJ

更新日期：1998-05-01 00:00:00

abstract：:During the first weeks of human immunodeficiency virus-1 (HIV-1) infection, cytotoxic T-lymphocytes (CTLs) select for multiple escape mutations in the infecting HIV population. In recent years, methods that use escape mutation data to estimate rates of HIV escape have been developed, thereby providing a quantitative f...

journal_title：Genetics

authors： Leviyang S

更新日期：2013-07-01 00:00:00

abstract：:A female frog heterozygous at two unlinked loci, specifying electrophoretic forms of mannosephosphate isomerase (MPI) and malate dehydrogenase (MDH) was crossed to male frogs homozygous for different alleles at each locus. In the offspring approximately ten percent proved to be triploid according to nucleolar and chro...

journal_title：Genetics

authors： Wright DA,Huang CP,Chuoke BD

更新日期：1976-10-01 00:00:00

abstract：:Programmed cell death (PCD) is regulated by multiple evolutionarily conserved mechanisms to ensure the survival of the cell. Here we describe pvl-5, a gene that likely regulates PCD in Caenorhabditis elegans. In wild-type hermaphrodites at the L2 stage there are 11 Pn.p hypodermal cells in the ventral midline arrayed ...

journal_title：Genetics

authors： Joshi P,Eisenmann DM

更新日期：2004-06-01 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...

journal_title：Genetics

authors： Dapa T,Fleurier S,Bredeche MF,Matic I

更新日期：2017-07-01 00:00:00

abstract：:In meiosis, multiple different DNA sequence motifs help to position homologous recombination at hotspots in the genome. How do the seemingly disparate cis-acting regulatory modules each promote locally the activity of the basal recombination machinery? We defined molecular mechanisms of action for five different hotsp...

journal_title：Genetics

authors： Mukiza TO,Protacio RU,Davidson MK,Steiner WW,Wahls WP

更新日期：2019-11-01 00:00:00

abstract：:Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...

journal_title：Genetics

authors： Grognet P,Bidard F,Kuchly C,Tong LC,Coppin E,Benkhali JA,Couloux A,Wincker P,Debuchy R,Silar P

更新日期：2014-05-01 00:00:00

abstract：:We analyzed linkage and chromosomal positions of genes in A. lyrata ssp. petraea that are located near the centromere (CEN) regions of A. thaliana, using at least two genes from the short and long arms of each chromosome. In our map, genes from all 10 A. thaliana chromosome arms are also tightly linked in A. lyrata. G...

journal_title：Genetics

authors： Kawabe A,Hansson B,Hagenblad J,Forrest A,Charlesworth D

更新日期：2006-07-01 00:00:00

abstract：:Signaling by receptor tyrosine kinases (RTKs) is critical for a multitude of developmental decisions and processes. Among the molecules known to transduce the RTK-generated signal is the nonreceptor protein tyrosine phosphatase Corkscrew (Csw). Previously, Csw has been demonstrated to function throughout the Drosophil...

journal_title：Genetics

authors： Firth L,Manchester J,Lorenzen JA,Baron M,Perkins LA

更新日期：2000-10-01 00:00:00

abstract：:We present a genetic map based on microsatellite polymorphisms for the African human malaria vector, Anopheles gambiae. Polymorphisms in laboratory strains were detected for 89% of the tested microsatellite markers. Genotyping was performed for individual mosquitos from 13 backcross families that included 679 progeny....

journal_title：Genetics

authors： Zheng L,Benedict MQ,Cornel AJ,Collins FH,Kafatos FC

更新日期：1996-06-01 00:00:00

abstract：:A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The...

journal_title：Genetics

authors： Cobbs G

更新日期：1986-06-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons of 14 sires and 206 genetic markers distributed across all 29 autosomes and flanking an estimated 2497 autosomal cM using Kosambi's mapping funct...

journal_title：Genetics

authors： Zhang Q,Boichard D,Hoeschele I,Ernst C,Eggen A,Murkve B,Pfister-Genskow M,Witte LA,Grignola FE,Uimari P,Thaller G,Bishop MD

更新日期：1998-08-01 00:00:00

abstract：:In response to an external source of adenine, yeast cells repress the expression of purine biosynthesis pathway genes. To identify necessary components of this signalling mechanism, we have isolated mutants that are constitutively active for expression. These mutants were named bra (for bypass of repression by adenine...

journal_title：Genetics

authors： Guetsova ML,Lecoq K,Daignan-Fornier B

更新日期：1997-10-01 00:00:00

abstract：:During meiosis homologous chromosomes replicate once, pair, experience recombination, and undergo two rounds of segregation to produce haploid meiotic products. The rec8(+), rec10(+), and rec11(+) genes of the fission yeast Schizosaccharomyces pombe exhibit similar specificities for meiotic recombination and rec8(+) i...

journal_title：Genetics

authors： Krawchuk MD,DeVeaux LC,Wahls WP

更新日期：1999-09-01 00:00:00

abstract：:Recessive mutations in three autosomal genes, him-1, him-5 and him-8, cause high levels of X chromosome nondisjunction in hermaphrodites of Caenorhabditis elegans, with no comparable effect on autosomal disjunction. Each of the mutants has reduced levels of X chromosome recombination, correlating with the increase in ...

journal_title：Genetics

authors： Broverman SA,Meneely PM

更新日期：1994-01-01 00:00:00

abstract：:Filamentous fungi undergo cytokinesis by forming crosswalls termed septa. Here, we describe the genetic and physiological controls governing septation in Aspergillus nidulans. Germinating conidia do not form septa until the completion of their third nuclear division. The first septum is invariantly positioned at the b...

journal_title：Genetics

authors： Harris SD,Morrell JL,Hamer JE

更新日期：1994-02-01 00:00:00

abstract：:A genetic linkage map was constructed in a backcross family of the red flour beetle, Tribolium castaneum, based largely on sequences from bacterial artificial chromosome (BAC) ends and untranslated regions from random cDNA's. In most cases, dimorphisms were detected using heteroduplex or single-strand conformational p...

journal_title：Genetics

authors： Lorenzen MD,Doyungan Z,Savard J,Snow K,Crumly LR,Shippy TD,Stuart JJ,Brown SJ,Beeman RW

更新日期：2005-06-01 00:00:00

abstract：:Retrotransposons are mobile genetic elements that colonize eukaryotic genomes by replicating through an RNA intermediate. As retrotransposons can move within the host genome, defense mechanisms have evolved to repress their potential mutagenic activities. In the fission yeast Schizosaccharomyces pombe, the mRNA of Tf2...

journal_title：Genetics

authors： Mallet PL,Larochelle M,Bachand F

更新日期：2017-02-01 00:00:00

abstract：:The larval body wall muscles of Drosophila melanogaster arise by fusion of founder myoblasts (FMs) and fusion-competent myoblasts (FCMs). Sticks-and-Stones (SNS) is expressed on the surface of all FCMs and mediates adhesion with FMs and developing syncytia. Intracellular components essential for myoblast fusion are th...

journal_title：Genetics

authors： Kocherlakota KS,Wu JM,McDermott J,Abmayr SM

更新日期：2008-03-01 00:00:00

abstract：:A causal link between deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina. To gain more insight into the relationship between mitochondrial function and life span, we have constructed a strain carrying a thermosensitive mutation of the gene o...

journal_title：Genetics

authors： Sellem CH,Lemaire C,Lorin S,Dujardin G,Sainsard-Chanet A

更新日期：2005-03-01 00:00:00

abstract：:The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

journal_title：Genetics

authors： Cochran DG

更新日期：1983-05-01 00:00:00