The isolation and characterization of nrc-1 and nrc-2, two genes encoding protein kinases that control growth and development in Neurospora crassa.

abstract：:During meiosis homologous chromosomes replicate once, pair, experience recombination, and undergo two rounds of segregation to produce haploid meiotic products. The rec8(+), rec10(+), and rec11(+) genes of the fission yeast Schizosaccharomyces pombe exhibit similar specificities for meiotic recombination and rec8(+) i...

journal_title：Genetics

authors： Krawchuk MD,DeVeaux LC,Wahls WP

更新日期：1999-09-01 00:00:00

abstract：:In Saccharomyces cerevisiae, the Rad52 protein plays a role in both RAD51-dependent and RAD51-independent recombination pathways. We characterized a rad52 mutant, rad52-329, which lacks the C-terminal Rad51-interacting domain, and studied its role in RAD51-independent recombination. The rad52-329 mutant is completely ...

journal_title：Genetics

authors： Tsukamoto M,Yamashita K,Miyazaki T,Shinohara M,Shinohara A

更新日期：2003-12-01 00:00:00

abstract：:Linkage relationships of nine enzyme loci; aconitase (Acon ), esterase (Est), glucosephosphate isomerase A and B ( Gpi), glycerate-2-dehydrogenase (G2dh), malic enzyme (Me ), phosphoglycerate kinase (Pgk), phosphoglucomutase (Pgm ) and superoxide dismutase (Sod), were investigated in sunfishes (Lepomis, Centrarchidae)...

journal_title：Genetics

authors： Pasdar M,Philipp DP,Whitt GS

更新日期：1984-07-01 00:00:00

abstract：:We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. ...

journal_title：Genetics

authors： Fearnhead P

更新日期：2006-11-01 00:00:00

abstract：:Notch signaling pathways can be regulated through a variety of cellular mechanisms, and genetically compromised systems provide useful platforms from which to search for the responsible modulators. The Caenorhabditis elegans gene aph-1 encodes a component of γ-secretase, which is essential for Notch signaling events t...

journal_title：Genetics

authors： Hale VA,Guiney EL,Goldberg LY,Haduong JH,Kwartler CS,Scangos KW,Goutte C

更新日期：2012-03-01 00:00:00

abstract：:Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus). This suggests that these genes may contribute to control...

journal_title：Genetics

authors： Pryce JE,Hayes BJ,Bolormaa S,Goddard ME

更新日期：2011-03-01 00:00:00

abstract：:The challenges of breeding autotetraploid potato (Solanum tuberosum) have motivated the development of alternative breeding strategies. A common approach is to obtain uniparental dihaploids from a tetraploid of interest through pollination with S. tuberosum Andigenum Group (formerly S. phureja) cultivars. The mechanis...

journal_title：Genetics

authors： Amundson KR,Ordoñez B,Santayana M,Tan EH,Henry IM,Mihovilovich E,Bonierbale M,Comai L

更新日期：2020-02-01 00:00:00

abstract：:Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from Drosophila to humans. Here, we...

journal_title：Genetics

authors： Nagarkar S,Wasnik R,Govada P,Cohen S,Shashidhara LS

更新日期：2020-09-01 00:00:00

abstract：:We describe a method for co-estimating r = C/mu (where C is the per-site recombination rate and mu is the per-site neutral mutation rate) and Theta = 4N(e)mu (where N(e) is the effective population size) from a population sample of molecular data. The technique is Metropolis-Hastings sampling: we explore a large numbe...

journal_title：Genetics

authors： Kuhner MK,Yamato J,Felsenstein J

更新日期：2000-11-01 00:00:00

abstract：:Nonautonomous inductive signals from the soma and autonomous signals due to a 2X karyotype determine the sex of Drosophila melanogaster germ cells. These two signals have partially overlapping influences on downstream sex determination genes. The upstream OVO-B transcription factor is required for the viability of 2X ...

journal_title：Genetics

authors： Andrews J,Oliver B

更新日期：2002-02-01 00:00:00

abstract：:The central and marginal populations of D. robusta differ greatly in the level of inversion polymorphism; the marginal populations are monomorphic or nearly so and the central populations are highly polymorphic. This paper presents the frequencies of alleles at forty gene loci in various populations of D. robusta, stu...

journal_title：Genetics

authors： Prakash S

更新日期：1973-10-01 00:00:00

abstract：:RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12 polypeptides where Rpb1 is the largest subunit. To further understand the mechanisms of RNAPII transcription, we isolated and characterized novel point mutants of RPB1 that are sensitive to ...

journal_title：Genetics

authors： Malagon F,Kireeva ML,Shafer BK,Lubkowska L,Kashlev M,Strathern JN

更新日期：2006-04-01 00:00:00

abstract：:We have examined the stability of the tandemly repeated genes that encode the ribosomal RNA in Coprinus cinereus. These genes are contained within two linked HindIII fragments in a 3.0-Mb chromosome. We monitored the size of these fragments in both mitotic and meiotic segregants using the contour-clamped homogeneous e...

journal_title：Genetics

authors： Pukkila PJ,Skrzynia C

更新日期：1993-02-01 00:00:00

abstract：:Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-s...

journal_title：Genetics

authors： Phillips PC,Johnson NA

更新日期：1998-09-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Neurospora crassa has been a model organism for the study of circadian clocks for the past four decades. Among natural accessions of Neurospora crassa, there is significant variation in clock phenotypes. In an attempt to investigate natural allelic variants contributing to quantitative variation, we used a quantitativ...

journal_title：Genetics

authors： Kim TS,Logsdon BA,Park S,Mezey JG,Lee K

更新日期：2007-12-01 00:00:00

abstract：:Catfish is the major aquaculture species in the United States. The hybrid catfish produced by crossing channel catfish females with blue catfish males exhibit a number of desirable production traits, but their mass production has been difficult. To introduce desirable genes from blue catfish into channel catfish throu...

journal_title：Genetics

authors： Liu Z,Karsi A,Li P,Cao D,Dunham R

更新日期：2003-10-01 00:00:00

abstract：:Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...

journal_title：Genetics

authors： Hofnung M

更新日期：1974-02-01 00:00:00

abstract：:A key quantity in the analysis of structured populations is the parameter K, which describes the number of subpopulations that make up the total population. Inference of K ideally proceeds via the model evidence, which is equivalent to the likelihood of the model. However, the evidence in favor of a particular value o...

journal_title：Genetics

authors： Verity R,Nichols RA

更新日期：2016-08-01 00:00:00

abstract：:The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of small populations. Properties of the DFE can be inferred by comparing the distributions of the frequencies of segregating nuc...

journal_title：Genetics

authors： Keightley PD,Eyre-Walker A

更新日期：2007-12-01 00:00:00

abstract：:There are two common alleles at the Amylase-2 locus in populations of Gammarus palustris, the salt marsh amphipod. Intensive sampling of individuals from two localities at Jamaica Bay revealed a consistent pattern of heterozygote deficiency.-Five possible sources of heterozygote deficiency were examined in this study....

journal_title：Genetics

authors： Borowsky R,Borowsky B,Milani H,Greenberg P

更新日期：1985-10-01 00:00:00

abstract：:The T4 mutations px, y and 1206 inactivate an error-prone recombination-like repair system, reducing or abolishing mutagenesis by UV irradiation, MMS, and white light irradiation in the presence of the photosensitizer 8MOP. Both px and y increase some spontaneous mutation rates and slightly enhance proflavin mutagenes...

journal_title：Genetics

authors： Green RR,Drake JW

更新日期：1974-09-01 00:00:00

abstract：:The long terminal repeat retrotransposon, Magnaporthe gypsy-like element (MAGGY), has been shown to be targeted for cytosine methylation in a subset of Magnaporthe oryzae field isolates. Analysis of the F1 progeny from a genetic cross between methylation-proficient (Br48) and methylation-deficient (GFSI1-7-2) isolates...

journal_title：Genetics

authors： Ikeda K,Van Vu B,Kadotani N,Tanaka M,Murata T,Shiina K,Chuma I,Tosa Y,Nakayashiki H

更新日期：2013-11-01 00:00:00

abstract：:In the absence of a vg+ gene, extensive cell death occurs in third instar imaginal discs, which results in a complete loss of adult wing margin structures. Essentially all molecularly characterized vg alleles are associated with deletions or insertions of DNA into the vg locus. These alterations reduce or eliminate a ...

journal_title：Genetics

authors： Williams JA,Scott IM,Atkin AL,Brook WJ,Russell MA,Bell JB

更新日期：1990-08-01 00:00:00

abstract：:Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general conte...

journal_title：Genetics

authors： Vitezica ZG,Legarra A,Toro MA,Varona L

更新日期：2017-07-01 00:00:00

abstract：:As a genetic mutation is passed down across generations, it distinguishes those genomes that have inherited it from those that have not, providing a glimpse of the genealogical tree relating the genomes to each other at that site. Statistical summaries of genetic variation therefore also describe the underlying geneal...

journal_title：Genetics

authors： Ralph P,Thornton K,Kelleher J

更新日期：2020-07-01 00:00:00

abstract：:Theoretically, one of the most general benefits of sex is given by its function in facilitating selection against deleterious mutations. This advantage of sex may be deterministic if deleterious mutations affect the fitness of an individual in a synergistic way, i.e., if mutations increase each others' negative fitnes...

journal_title：Genetics

authors： de Visser JA,Hoekstra RF,van den Ende H

更新日期：1997-03-01 00:00:00

abstract：:To develop a catalog of regulatory sites in two major model organisms, Drosophila melanogaster and Caenorhabditis elegans, the modERN (model organism Encyclopedia of Regulatory Networks) consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecess...

journal_title：Genetics

authors： Kudron MM,Victorsen A,Gevirtzman L,Hillier LW,Fisher WW,Vafeados D,Kirkey M,Hammonds AS,Gersch J,Ammouri H,Wall ML,Moran J,Steffen D,Szynkarek M,Seabrook-Sturgis S,Jameel N,Kadaba M,Patton J,Terrell R,Corson M,Dur

更新日期：2018-03-01 00:00:00

abstract：:Yeast cells subjected to a reversible thermal arrest of meiosis yielded progressively fewer spores per ascus as the arrest was extended. Dissection of two-spored asci by a newly developed method that prevents selection of false asci revealed that the spores were not a random sample of the haploid meiotic products. Mos...

journal_title：Genetics

authors： Davidow LS,Goetsch L,Byers B

更新日期：1980-03-01 00:00:00

abstract：:Inbreeding depression, which refers to reduced fitness among offspring of related parents, has traditionally been studied using pedigrees. In practice, pedigree information is difficult to obtain, potentially unreliable, and rarely assessed for inbreeding arising from common ancestors who lived more than a few generat...

journal_title：Genetics

authors： Keller MC,Visscher PM,Goddard ME

更新日期：2011-09-01 00:00:00