Perfect simulation from nonneutral population genetic models: variable population size and population subdivision.

abstract：:l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional misexpression of the gene associated with this mutation as well as with several euchromatic insertions of l(3)S12+ transposons. S...

journal_title：Genetics

authors： Dutton FL Jr,Chovnick A

更新日期：1991-05-01 00:00:00

abstract：:In Drosophila melanogaster, the female sexual development of the soma and the germline requires the activity of the gene Sxl. The somatic cells need the function of the gene fl(2)d to follow the female developmental pathway, due to its involvement in the female-specific splicing of Sxl RNA. Here we report the analysis...

journal_title：Genetics

authors： Granadino B,San Juán A,Santamaria P,Sánchez L

更新日期：1992-03-01 00:00:00

abstract：:The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...

journal_title：Genetics

authors： Daetwyler HD,Calus MP,Pong-Wong R,de Los Campos G,Hickey JM

更新日期：2013-02-01 00:00:00

abstract：:Sister-chromatid exchanges (SCE) were studied in allium cepa L. meristematic cells at the second and third divisions after BrdUrd-substitution during just the first or during the second and third cycles, respectively. The observed SCE nonreciprocal/reciprocal ratios detected at the third division in both experiments, ...

journal_title：Genetics

authors： Schvartzman JB,Cortés F,González-Fernández A,Gutiérrez C,López-Sáez JF

更新日期：1979-08-01 00:00:00

abstract：:From the analysis of restriction maps of the Amy region in eight sibling species belonging to the Drosophila melanogaster species subgroup, we herein show that the patterns of duplication of the Amy gene are almost the same in all species. This indicates that duplication occurred before speciation within this species ...

journal_title：Genetics

authors： Shibata H,Yamazaki T

更新日期：1995-09-01 00:00:00

abstract：:Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...

journal_title：Genetics

authors： Shaw RG,Platenkamp GA,Shaw FH,Podolsky RH

更新日期：1995-01-01 00:00:00

abstract：:Heparan sulfates (HS) are linear polysaccharides with complex modification patterns, which are covalently bound via conserved attachment sites to core proteins to form heparan sulfate proteoglycans (HSPGs). HSPGs regulate many aspects of the development and function of the nervous system, including cell migration, mor...

journal_title：Genetics

authors： Saied-Santiago K,Townley RA,Attonito JD,da Cunha DS,Díaz-Balzac CA,Tecle E,Bülow HE

更新日期：2017-08-01 00:00:00

abstract：:The shibire locus of Drosophila melanogaster encodes dynamin, a GTPase required for the fission of endocytic vesicles from plasma membrane. Biochemical studies indicate that mammalian dynamin is part of a complex containing multiple dynamin subunits and other polypeptides. To gain insight into sequences of dynamin cri...

journal_title：Genetics

authors： Grant D,Unadkat S,Katzen A,Krishnan KS,Ramaswami M

更新日期：1998-06-01 00:00:00

abstract：:Since the publication of the first comprehensive linkage map for the laboratory mouse, the architecture of recombination as a basic biological process has become amenable to investigation in mammalian model organisms. Here we take advantage of high-density genotyping and the unique pedigree structure of the incipient ...

journal_title：Genetics

authors： Liu EY,Morgan AP,Chesler EJ,Wang W,Churchill GA,Pardo-Manuel de Villena F

更新日期：2014-05-01 00:00:00

abstract：:A consensus map for loblolly pine (Pinus taeda L.) was constructed from the integration of linkage data from two unrelated three-generation outbred pedigrees. The progeny segregation data from restriction fragment length polymorphism, random amplified polymorphic DNA, and isozyme genetic markers from each pedigree wer...

journal_title：Genetics

authors： Sewell MM,Sherman BK,Neale DB

更新日期：1999-01-01 00:00:00

abstract：:Electrophoretic comparisons of 40S and 55S ribosomal subunit proteins from 18 strains of Drosophila melanogaster revealed the virtual absence of allelic variation. More detailed two-dimensional studies on the large subunit proteins in 6 of the strains demonstrated additional complexity but still no interstrain variati...

journal_title：Genetics

authors： Berger EM,Weber L

更新日期：1974-12-01 00:00:00

abstract：:The process designated RIP (repeat-induced point mutation) alters duplicated DNA sequences in the sexual cycle of Neurospora crassa. We tested whether non-Neurospora sequences are susceptible to RIP, explored the basis for the observed immunity to this process of a diverged tandem duplication that probably arose by a ...

journal_title：Genetics

authors： Foss EJ,Garrett PW,Kinsey JA,Selker EU

更新日期：1991-04-01 00:00:00

abstract：:We have characterized a Saccharomyces cerevisiae mutant strain that is hypersensitive to cyclosporin A (CsA) and FK506, immunosuppressants that inhibit calcineurin, a serine-threonine-specific phosphatase (PP2B). A single nuclear mutation, designated cev1 for calcineurin essential for viability, is responsible for the...

journal_title：Genetics

authors： Hemenway CS,Dolinski K,Cardenas ME,Hiller MA,Jones EW,Heitman J

更新日期：1995-11-01 00:00:00

abstract：:In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silence...

journal_title：Genetics

authors： Zou Y,Yu Q,Chiu YH,Bi X

更新日期：2006-09-01 00:00:00

abstract：:Much recent work in the theoretical study of adaptation has focused on the so-called strong selection-weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution. Here we extend this t...

journal_title：Genetics

authors： Unckless RL,Orr HA

更新日期：2009-11-01 00:00:00

abstract：:hunchback (hb) is a key regulatory gene in the early segmentation gene hierarchy of Drosophila. It codes for a transcription factor of the Cys2-His2 zinc finger type and shows two separate zinc finger domains in its coding region. hb forms a morphogenetic gradient in the middle of the embryo that is required for setti...

journal_title：Genetics

authors： Hülskamp M,Lukowitz W,Beermann A,Glaser G,Tautz D

更新日期：1994-09-01 00:00:00

abstract：:The mutation process at microsatellite loci typically occurs at high rates and with stepwise changes in allele sizes, features that may introduce bias when using classical measures of population differentiation based on allele identity (e.g., F(ST), Nei's Ds genetic distance). Allele size-based measures of differentia...

journal_title：Genetics

authors： Hardy OJ,Charbonnel N,Fréville H,Heuertz M

更新日期：2003-04-01 00:00:00

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00

abstract：:fl(2)d, the Drosophila homolog of Wilms'-tumor-1-associated protein (WTAP), regulates the alternative splicing of Sex-lethal (Sxl), transformer (tra), and Ultrabithorax (Ubx). Although WTAP has been found in functional human spliceosomes, exactly how it contributes to the splicing process remains unknown. Here we atte...

journal_title：Genetics

authors： Penn JK,Graham P,Deshpande G,Calhoun G,Chaouki AS,Salz HK,Schedl P

更新日期：2008-02-01 00:00:00

abstract：:We use the ancestral influence graph (AIG) for a two-locus, two-allele selection model in the limit of a large population size to obtain an analytic approximation for the probability of ultimate fixation of a single mutant allele A. We assume that this new mutant is introduced at a given locus into a finite population...

journal_title：Genetics

authors： Lessard S,Kermany AR

更新日期：2012-02-01 00:00:00

abstract：:Post-transcriptional RNA processing is an important regulatory control mechanism for determining the phenotype of eukaryotic cells. The processing of a transcribed RNA species into alternative splice isoforms yields products that can perform different functions. Each type of cell in a multi-cellular organism is presum...

journal_title：Genetics

authors： Chisa JL,Burke DT

更新日期：2007-03-01 00:00:00

abstract：:Secondary trisomics and telotrisomics representing the 12 chromosomes of rice were isolated from the progenies of primary trisomics. A large population of each primary trisomic was grown. Plants showing variation in gross morphology compared to the primary trisomics and disomic sibs were selected and analyzed cytologi...

journal_title：Genetics

authors： Singh K,Multani DS,Khush GS

更新日期：1996-05-01 00:00:00

abstract：:We explore the effects of demography and linkage on a maximum-likelihood (ML) method for estimating selection and mutation parameters in a reversible mutation model. This method assumes free recombination between sites and a randomly mating population of constant size and uses information from both polymorphic and mon...

journal_title：Genetics

authors： Zeng K,Charlesworth B

更新日期：2010-12-01 00:00:00

abstract：:Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...

journal_title：Genetics

authors： Hofnung M

更新日期：1974-02-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...

journal_title：Genetics

authors： Burke GR,McLaughlin HJ,Simon JC,Moran NA

更新日期：2010-09-01 00:00:00

abstract：:The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic con...

journal_title：Genetics

authors： Emmerich J,Meyer CA,de la Cruz AF,Edgar BA,Lehner CF

更新日期：2004-10-01 00:00:00

abstract：:We have examined the effects of prolonged histidine deprivation on the reversion of Salmonella typhimurium histidine auxotrophs containing either hisG46, a missense mutation (CTC----CCC), or hisG428, an ochre mutation (CAA----TAA). Both of these mutants can revert to His+ via intragenic and extragenic mechanisms. Wher...

journal_title：Genetics

authors： Prival MJ,Cebula TA

更新日期：1992-10-01 00:00:00

abstract：:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...

journal_title：Genetics

authors： Hellenthal G,Pritchard JK,Stephens M

更新日期：2006-03-01 00:00:00

abstract：:Phosphatidylinositol catabolism in Saccharomyces cerevisiae cells cultured in media containing inositol results in the release of glycerophosphoinositol (GroPIns) into the medium. As the extracellular concentration of inositol decreases with growth, the released GroPIns is transported back into the cell. Exploiting th...

journal_title：Genetics

authors： Patton-Vogt JL,Henry SA

更新日期：1998-08-01 00:00:00