Linkage relationships of nine enzyme Loci in sunfishes (lepomis; centrarchidae).

abstract：:Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...

journal_title：Genetics

authors： Lieberman HB

更新日期：1995-09-01 00:00:00

abstract：:The genetics of the ciliate Tetrahymena thermophila are richer than for most other eukaryotic cells, because Tetrahymena possesses two genomes: a germline (micronuclear) genome that follows a Mendelian model of genetic transmission and a somatic (macronuclear) genome, derived from the micronuclear genome by fragmentat...

journal_title：Genetics

authors： Wickert S,Nangle L,Shevel S,Orias E

更新日期：2000-03-01 00:00:00

abstract：:A model of the evolution of a transposable element family in a Mendelian host population is proposed that incorporates heritable phenotypic mutations in the elements. The temporal behavior of the numbers of mutant and wild-type elements is studied, and the expected extinction time of the transposable element family is...

journal_title：Genetics

authors： Kaplan N,Darden T,Langley CH

更新日期：1985-02-01 00:00:00

abstract：:We show how to incorporate fluctuations of the recombination rate along the chromosome into standard gene-genealogical models for the decorrelation of gene histories. This enables us to determine how small-scale fluctuations (Poissonian hot-spot model) and large-scale variations (Kong et al. 2002) of the recombination...

journal_title：Genetics

authors： Eriksson A,Mehlig B

更新日期：2005-02-01 00:00:00

abstract：:The mutation rates of specific loci and chromosome regions were estimated for two types of dysgenic hybrid males. These came from crosses between P or Q males and M females in the P-M system of hybrid dysgenesis. The M X P hybrids were the more mutable for each of the loci and chromosome regions tested. The Beadex loc...

journal_title：Genetics

authors： Simmons MJ,Raymond JD,Johnson NA,Fahey TM

更新日期：1984-01-01 00:00:00

abstract：:Mobile P elements in Drosophila melanogaster cause hybrid dysgenesis if their mobility is not repressed. One type of repression, termed P cytotype, is a complex interaction between chromosomes carrying P elements and cytoplasm and is transmitted through the cytoplasm only of females. Another type of repression is foun...

journal_title：Genetics

authors： Jackson MS,Black DM,Dover GA

更新日期：1988-12-01 00:00:00

abstract：:Mutations affecting the self-incompatibility response of Nicotiana alata were generated by irradiation. Mutants in the M1 generation were selected on the basis of pollen tube growth through an otherwise incompatible pistil. Twelve of the 18 M1 plants obtained from the mutagenesis screen were self-compatible. Eleven se...

journal_title：Genetics

authors： Golz JF,Su V,Clarke AE,Newbigin E

更新日期：1999-07-01 00:00:00

abstract：:Some mutant strains of the filamentous fungus Podospora anserina spontaneously present a growth impairment, which has been called Crippled Growth (CG). CG is caused by a cytoplasmic and infectious factor, C. C is efficiently transmitted during mitosis but is not transmitted to the progeny after sexual crosses. C is in...

journal_title：Genetics

authors： Silar P,Haedens V,Rossignol M,Lalucque H

更新日期：1999-01-01 00:00:00

abstract：:The Arabidopsis SECRET AGENT (SEC) and SPINDLY (SPY) proteins are similar to animal O-linked N-acetylglucosamine transferases (OGTs). OGTs catalyze the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to Ser/Thr residues of proteins. In animals, O-GlcNAcylation has been shown to affect protein activity, stabil...

journal_title：Genetics

authors： Hartweck LM,Scott CL,Olszewski NE

更新日期：2002-07-01 00:00:00

abstract：:The MITF protein is a member of the MYC family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors and is most closely related to the TFE3, TFEC, and TFEB proteins. In the mouse, MITF is required for the development of several different cell types, including the retinal pigment epithelial (RPE) c...

journal_title：Genetics

authors： Hallsson JH,Haflidadóttir BS,Stivers C,Odenwald W,Arnheiter H,Pignoni F,Steingrímsson E

更新日期：2004-05-01 00:00:00

abstract：:When a polygenic character is exposed to natural selection in which the curve giving fitness as a function of phenotype is a mixture of two Gaussian (normal) curves, the population may respond either by evolving to a specialized phenotype near one of the two optimum phenotypes, or by evolving to a generalized phenotyp...

journal_title：Genetics

authors： Felsenstein J

更新日期：1979-11-01 00:00:00

abstract：:We have genetically analyzed, cloned and physically mapped the modified cytosine-specific restriction determinants mcrA (rglA) and mcrB (rglB) of Escherichia coli K-12. The independently discovered Rgl and Mcr restriction systems are shown to be identical by three criteria: 1) mutants with the RglA- or RglB- phenotype...

journal_title：Genetics

authors： Raleigh EA,Trimarchi R,Revel H

更新日期：1989-06-01 00:00:00

abstract：:Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the eluci...

journal_title：Genetics

authors： Greenwald I

更新日期：2012-07-01 00:00:00

abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

journal_title：Genetics

authors： Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

更新日期：2017-10-01 00:00:00

abstract：:Rare genetic variants have recently been studied for genome-wide associations with human complex diseases. Existing rare variant methods are based on the hypothesis-testing framework that predefined variant sets need to be tested separately. The power of those methods is contingent upon accurate selection of variants ...

journal_title：Genetics

authors： Zhang Y,Ghosh S,Hakonarson H

更新日期：2014-11-01 00:00:00

abstract：:The Genetics Society of America's George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers and who exemplify the qualities of its namesake as a respected academic, administrator, and public servant. The 2015 recipient is John Postlethwait. He has made g...

journal_title：Genetics

authors： Postlethwait JH

更新日期：2015-07-01 00:00:00

abstract：:Biofilms are microbial communities that form on surfaces. They are the primary form of microbial growth in nature and can have detrimental impacts on human health. Some strains of the budding yeast Saccharomyces cerevisiae form colony biofilms, and there is substantial variation in colony architecture between biofilm-...

journal_title：Genetics

authors： Granek JA,Murray D,Kayrkçi Ö,Magwene PM

更新日期：2013-02-01 00:00:00

abstract：:Changes in genome structure and gene expression have been documented in both resynthesized and natural allopolyploids that contain two or more divergent genomes. The underlying mechanisms for rapid and stochastic changes in gene expression are unknown. Arabidopsis suecica is a natural allotetraploid derived from the e...

journal_title：Genetics

authors： Chen M,Ha M,Lackey E,Wang J,Chen ZJ

更新日期：2008-04-01 00:00:00

abstract：:The murine dilute suppressor gene (dsu) suppresses the coat-color phenotype of three pigment mutations, dilute (d), ashen (ash) and leaden (ln), that each produce adendritic melanocytes. Suppression is due to the ability of dsu to partially restore (ash and ln), or almost completely restore (d), normal melanocyte morp...

journal_title：Genetics

authors： Moore KJ,Swing DA,Copeland NG,Jenkins NA

更新日期：1994-10-01 00:00:00

abstract：:In both pedigree linkage studies and in population-based association studies there has been much interest in the use of modern dense genetic marker data to infer segments of gene identity by descent (ibd) among individuals not known to be related, to increase power and resolution in localizing genes affecting complex ...

journal_title：Genetics

authors： Brown MD,Glazner CG,Zheng C,Thompson EA

更新日期：2012-04-01 00:00:00

abstract：:The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

journal_title：Genetics

authors： Cochran DG

更新日期：1983-05-01 00:00:00

abstract：:Escherichia coli K12 does not metabolize beta-glucosides such as arbutin and salicin because of lack of expression of the bglBSRC operon, which contains structural genes for transport (bglC) and hydrolysis (bglB) of phospho-beta-glucosides. Mutants carrying lesions in the cis-acting regulatory site bglR metabolize bet...

journal_title：Genetics

authors： Defez R,De Felice M

更新日期：1981-01-01 00:00:00

abstract：:Site-specific recombinases are widely used tools for analysis of genetics, development, and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because the FRT and lox target sites for the commonly used FLP and Cre recombinases are asymmetrical, and mus...

journal_title：Genetics

authors： Titen SWA,Johnson MTB,Capecchi M,Golic KG

更新日期：2020-08-01 00:00:00

abstract：:We have analyzed the 2E1-3A1 area of the X chromosome with special attention to loci related to embryogenesis. Published maps indicate that this chromosomal segment contains ten bands. Our genetic analysis has identified 11 complementation groups: one recessive visible (prune), two female steriles and eight lethals. O...

journal_title：Genetics

authors： Perrimon N,Engstrom L,Mahowald AP

更新日期：1984-11-01 00:00:00

abstract：:A maximum-likelihood method to estimate the recombination fraction and its sampling variance using informative and noninformative half-sib offspring is derived. Estimates of the recombination fraction are biased up to 20 cM when noninformative offspring are discarded. In certain scenarios, the sampling variance can be...

journal_title：Genetics

authors： Gomez-Raya L

更新日期：2001-03-01 00:00:00

abstract：:Hybrid sterility is a common form of reproductive isolation between nascent species. Although hybrid sterility is routinely documented and genetically dissected in speciation studies, its developmental basis is rarely examined, especially in generations beyond the F1 generation. To identify phenotypic and genetic dete...

journal_title：Genetics

authors： Schwahn DJ,Wang RJ,White MA,Payseur BA

更新日期：2018-12-01 00:00:00

abstract：:Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due ...

journal_title：Genetics

authors： Heath AC,Martin NG,Eaves LJ,Loesch D

更新日期：1984-04-01 00:00:00

abstract：:Currently used tests of Hardy-Weinberg proportions do not take into account the nature of the alternative hypothesis, which is generally a heterozygote deficiency. Different exact tests, appropriate for small sample size and large number of alleles, are proposed in this perspective, and their properties are evaluated ...

journal_title：Genetics

authors： Rousset F,Raymond M

更新日期：1995-08-01 00:00:00

abstract：:In lytic cycle crosses with Red-Gam-lambda phage, particles were examined that had undergone an Int-mediated exchange. It was assumed that this exchange dimerized the circular lambda, making it packageable. Among these Int-mediated recombinants, particles were identified that had, in addition, enjoyed a close double e...

journal_title：Genetics

authors： Stahl FW,Lieb M,Stahl MM

更新日期：1984-12-01 00:00:00

abstract：:The POL3 encoded catalytic subunit of DNA polymerase delta possesses a highly conserved C-terminal cysteine-rich domain in Saccharomyces cerevisiae. Mutations in some of its cysteine codons display a lethal phenotype, which demonstrates an essential function of this domain. The thermosensitive mutant pol3-13, in which...

journal_title：Genetics

authors： Giot L,Chanet R,Simon M,Facca C,Faye G

更新日期：1997-08-01 00:00:00