Amplification of KP elements associated with the repression of hybrid dysgenesis in Drosophila melanogaster.

abstract：:Mitochondrial complex I is the largest multimeric enzyme of the respiratory chain. The lack of a model system with facile genetics has limited the molecular dissection of complex I assembly. Using Chlamydomonas reinhardtii as an experimental system to screen for complex I defects, we isolated, via forward genetics, am...

journal_title：Genetics

authors： Barbieri MR,Larosa V,Nouet C,Subrahmanian N,Remacle C,Hamel PP

更新日期：2011-06-01 00:00:00

abstract：:The X and Y chromosomes of Drosophila melanogaster each contain a cluster of several hundred ribosomal RNA genes (rDNA). A nontranscribed spacer region separates adjacent rRNA genes and contains tandem copies of 240 bp repeats that include the initiation site for RNA polymerase I transcription. We show here that Droso...

journal_title：Genetics

authors： Lohe AR,Roberts PA

更新日期：1990-06-01 00:00:00

abstract：:All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...

journal_title：Genetics

authors： Cyert MS,Philpott CC

更新日期：2013-03-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include ...

journal_title：Genetics

authors： Motro U,Thomson G

更新日期：1985-07-01 00:00:00

abstract：:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were de...

journal_title：Genetics

authors： Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SS

更新日期：1987-01-01 00:00:00

abstract：:Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "parti...

journal_title：Genetics

authors： Thomas-Orillard M,Jeune B,Cusset G

更新日期：1995-08-01 00:00:00

abstract：:Mutations affecting the self-incompatibility response of Nicotiana alata were generated by irradiation. Mutants in the M1 generation were selected on the basis of pollen tube growth through an otherwise incompatible pistil. Twelve of the 18 M1 plants obtained from the mutagenesis screen were self-compatible. Eleven se...

journal_title：Genetics

authors： Golz JF,Su V,Clarke AE,Newbigin E

更新日期：1999-07-01 00:00:00

abstract：:An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters containing 4607 genes, over one-fifth of all genes in C. elegans. Cluster genes are distributed unevenly in the genome, with t...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-01-01 00:00:00

abstract：:Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

journal_title：Genetics

authors： Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

更新日期：2007-07-01 00:00:00

abstract：:The primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptide...

journal_title：Genetics

authors： Akashi H

更新日期：2003-08-01 00:00:00

abstract：:We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretation...

journal_title：Genetics

authors： Housworth EA,Stahl FW

更新日期：2009-09-01 00:00:00

abstract：:Drosophila adult leg development provides an ideal model system for characterizing the molecular mechanisms of hormone-triggered morphogenesis. A pulse of the steroid hormone ecdysone at the onset of metamorphosis triggers the rapid transformation of a flat leg imaginal disc into an immature adult leg, largely through...

journal_title：Genetics

authors： Ward RE,Evans J,Thummel CS

更新日期：2003-11-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Despite remarkable success in uncovering many risk variants and providing novel insights into disease biology, genetic variants identified to date fail to explain the vast majority of the heri...

journal_title：Genetics

authors： Huang J,Wang K,Wei P,Liu X,Liu X,Tan K,Boerwinkle E,Potash JB,Han S

更新日期：2016-03-01 00:00:00

abstract：:A model of the evolution of a transposable element family in a Mendelian host population is proposed that incorporates heritable phenotypic mutations in the elements. The temporal behavior of the numbers of mutant and wild-type elements is studied, and the expected extinction time of the transposable element family is...

journal_title：Genetics

authors： Kaplan N,Darden T,Langley CH

更新日期：1985-02-01 00:00:00

abstract：:We propose a simple algorithm for estimating the number of nucleotide differences between a pair of RNA or DNA sequences through comparison of their RNAse A mismatch cleavage patterns. In the RNAse A mismatch cleavage technique two or more sample sequences are hybridized to the same RNA probe, the hybrids are partiall...

journal_title：Genetics

authors： Rzhetsky A,Dopazo J,Snyder E,Dangler CA,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary researc...

journal_title：Genetics

authors： Dymond JS,Scheifele LZ,Richardson S,Lee P,Chandrasegaran S,Bader JS,Boeke JD

更新日期：2009-01-01 00:00:00

abstract：:In vivo haploid induction (HI) triggered by pollination with special intraspecific genotypes, called inducers, is unique to Zea maysL. within the plant kingdom and has revolutionized maize breeding during the last decade. However, the molecular mechanisms underlying HI in maize are still unclear. To investigate the ge...

journal_title：Genetics

authors： Hu H,Schrag TA,Peis R,Unterseer S,Schipprack W,Chen S,Lai J,Yan J,Prasanna BM,Nair SK,Chaikam V,Rotarenco V,Shatskaya OA,Zavalishina A,Scholten S,Schön CC,Melchinger AE

更新日期：2016-04-01 00:00:00

abstract：:Biological robustness, the ability of an organism to maintain a steady-state output as genetic or environmental inputs change, is critical for proper development. MicroRNAs have been implicated in biological robustness mechanisms through their post-transcriptional regulation of genes and gene networks. Previous resear...

journal_title：Genetics

authors： Burke SL,Hammell M,Ambros V

更新日期：2015-08-01 00:00:00

abstract：:Many arthropod species are infected with maternally inherited endosymbionts that induce a shift in the sex ratio of their hosts by feminizing or killing males (cytoplasmic sex-ratio distorters, or SRDs). These endosymbionts can have profound impacts on evolutionary processes of their hosts. Here, I derive analytical e...

journal_title：Genetics

authors： Engelstädter J

更新日期：2010-09-01 00:00:00

abstract：:Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate between separation-of-...

journal_title：Genetics

authors： Lubin JW,Rao T,Mandell EK,Wuttke DS,Lundblad V

更新日期：2013-03-01 00:00:00

abstract：:The mutational origin and subsequent evolution of de novo genes, which are hypothesized to be genes of recent origin that are not obviously related to ancestral coding sequence, are poorly understood. However, accumulating evidence suggests that such genes may often function in male reproduction. Here we use testis-de...

journal_title：Genetics

authors： Begun DJ,Lindfors HA,Kern AD,Jones CD

更新日期：2007-06-01 00:00:00

abstract：:Two sets of overlapping experiments were conducted to examine recombination and spontaneous mutation events within clusters of resistance genes in lettuce. Multiple generations were screened for recombinants using PCR-based markers flanking Dm3. The Dm3 region is not highly recombinagenic, exhibiting a recombination f...

journal_title：Genetics

authors： Chin DB,Arroyo-Garcia R,Ochoa OE,Kesseli RV,Lavelle DO,Michelmore RW

更新日期：2001-02-01 00:00:00

abstract：:Clinal variation is common for enzymes in the glycolytic pathway for Drosophila melanogaster and is generally accepted as an adaptive response to different climates. Although the enzyme phosphoglucomutase (PGM) possesses several allozyme polymorphisms, it is unique in that it had been reported to show no clinal variat...

journal_title：Genetics

authors： Verrelli BC,Eanes WF

更新日期：2001-04-01 00:00:00

abstract：:Telomeric restriction fragments were genetically mapped to a previously described linkage map of Magnaporthe grisea, using RFLPs identified by a synthetic probe. (TTAGGG)3. Frequent rearrangement of telomeric sequences was observed in progeny isolates creating a potential for misinterpretation of data. Therefore a con...

journal_title：Genetics

authors： Farman ML,Leong SA

更新日期：1995-06-01 00:00:00

abstract：:By screening for suppressors of hypomorphic mutations of let-23, a receptor tyrosine kinase necessary for vulval induction in Caenorhabditis elegans, we recovered > or = 12 mutations defining the sli-1 (suppressor of lineage defect) locus. sli-1 mutations suppress four of five phenotypes associated with hypomorphic al...

journal_title：Genetics

authors： Jongeward GD,Clandinin TR,Sternberg PW

更新日期：1995-04-01 00:00:00

abstract：:At least six nuclear loci are responsible for the genetic control of malate dehydrogenase (L-malate: NAD oxidoreductase; EC 1.1.1.37; MDH) in coleoptiles of maize. Three independently segregating loci (Mdh1, Mdh2, Mdh3) govern the production of MDH isozymes resistant to inactivation by ascorbic acid and found largely ...

journal_title：Genetics

authors： Goodman MM,Stuber CW,Lee CN,Johnson FM

更新日期：1980-01-01 00:00:00

abstract：:The cut gene in Drosophila is necessary in at least one cell type, the external sensory organs, for proper cell type specification and morphogenesis. It is also expressed in a variety of other tissues, where its function is less well characterized. Previous work has demonstrated that mutations affecting all the tissue...

journal_title：Genetics

authors： Liu S,McLeod E,Jack J

更新日期：1991-01-01 00:00:00

abstract：:Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than conventional metaanalysis based on within-study estimates. However, conducting analyses with pooled genetic data, in particular, is a daunting task that raises importan...

journal_title：Genetics

authors： Heo M,Leibel RL,Boyer BB,Chung WK,Koulu M,Karvonen MK,Pesonen U,Rissanen A,Laakso M,Uusitupa MI,Chagnon Y,Bouchard C,Donohoue PA,Burns TL,Shuldiner AR,Silver K,Andersen RE,Pedersen O,Echwald S,Sørensen TI,Behn P,

更新日期：2001-11-01 00:00:00

abstract：:Biological evolution generates a surprising amount of site-specific variability in protein sequences. Yet, attempts at modeling this process have been only moderately successful, and current models based on protein structural metrics explain, at best, 60% of the observed variation. Surprisingly, simple measures of pro...

journal_title：Genetics

authors： Jiang Q,Teufel AI,Jackson EL,Wilke CO

更新日期：2018-04-01 00:00:00