Abstract：
:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were determined and compared with the protein-coding sequences of the mouse and rat LDH-A functional genes. In the pseudogene M11, the sequence of 64 nucleotides from codon no. 257 to 278 was tandemly duplicated. In the pseudogene M14, the sequence of 22 nucleotides from codon no. 68 to 75 was replaced by an inserted repetitive sequence of 242 nucleotides homologous to a mouse truncated R element. The pattern of nucleotide substitutions accumulated in mouse LDH-A pseudogenes M11 and M14, as well as that of pseudogene M10 identified previously, was analyzed, and the substitution frequencies of the C or G at the CG dinucleotide were found to be high.
journal_name
Geneticsjournal_title
Geneticsauthors
Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SSsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
177-84issue
1eissn
0016-6731issn
1943-2631journal_volume
115pub_type
杂志文章相关文献
GENETICS文献大全abstract：:This Perspectives article recounts the isolation and sequencing of the first human histocompatibility gene (HLA) in 1980-1981. At the time, general knowledge of the molecules of the immune system was already fairly extensive, and gene rearrangements in the immunoglobulin complex (discovered in 1976) had generated much...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.110.113852
更新日期：2010-04-01 00:00:00
abstract：:The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmen...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.051144
更新日期：2006-02-01 00:00:00
abstract：:Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.111.135590
更新日期：2012-02-01 00:00:00
abstract：:New rudimentary (r) mutants have been isolated following mutagenesis with ethyl methanesulfonate (r(LE)), ICR-170 (r(LI)) and X rays (r(LX)). From wing phenotype measurements on homoallelic females, it has been shown that the r(LE) mutant series includes several leaky alleles, as well as alleles that produce moderate ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：:Temporally spaced genetic data allow for more accurate inference of population genetic parameters and hypothesis testing on the recent action of natural selection. In this work, we develop a novel likelihood-based method for jointly estimating selection coefficient and allele age from time series data of allele freque...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303400
更新日期：2020-10-01 00:00:00
abstract：:In multicellular organisms, genetic programs guide cells to adopt cell fates as tissues are formed during development, maintained in adults, and repaired after injury. Here we explore how a small molecule in the environment can switch a genetic program from one fate to another. Wild-type Caenorhabditis elegans XX adul...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.169409
更新日期：2014-10-01 00:00:00
abstract：:We have examined the stability of duplicated DNA sequences in the sexual phase of the life cycle of the basidiomycete fungus, Coprinus cinereus. We observed premeiotic de novo methylation in haploid nuclei containing either a triplication, a tandem duplication, or an ectopic duplication. Methylation changes were not o...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. T...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase-5, adult acid phosphatase-6, phosphoglucomutase-1 and octanol dehydrogenase-3. The Standard arrangement which is the common arrangement in all populat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-08-01 00:00:00
abstract：:The construction in bacteriophage lambda of a set of long DNA palindromes with paired changes in the central sequence is described. Identical palindrome centers were previously used by others to test the S-type model for cruciform extrusion in vitro. Long DNA palindromes prevent the propagation of carrier phage lambda...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Heterologous yeast artificial chromosomes (YACs) do not recombine with each other and missegregate in 25% of meiosis I events. Recombination hot spots in the yeast Saccharomyces cerevisiae have previously been shown to be associated with sites of meiosis-induced double-strand breaks (DSBs). A 6-kb fragment containing ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The vacuolar hydrolase protease B in Saccharomyces cerevisiae is synthesized as an inactive precursor (Prb1p). The precursor undergoes post-translational modifications while transiting the secretory pathway. In addition to N- and O-linked glycosylations, four proteolytic cleavages occur during the maturation of Prb1p....
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:To understand the in vivo function of the unique and conserved carboxy-terminal repeat domain (CTD) of RNA polymerase II largest subunit (RpII215), we have studied RNA polymerase II biosynthesis, activity and genetic function in Drosophila RpII215 mutants that possessed all (C4), half (W81) or none (IIt) of the CTD re...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:The r-X1 deficiency in maize induces nondisjunction at the second mitotic division during embryo sac formation. However, it was not known if this deficiency also induces nondisjunction during the microspore divisions. Microsporogenesis in plants lacking or containing this deficiency was compared using two approaches. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.082206
更新日期：2007-12-01 00:00:00
abstract：:The Saccharomyces cerevisiae nuclear gene RPM2 encodes a component of the mitochondrial tRNA-processing enzyme RNase P. Cells grown on fermentable carbon sources do not require mitochondrial tRNA processing activity, but still require RPM2, indicating an additional function for the Rpm2 protein. RPM2-null cells arrest...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represen...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, another DNA helicase, c...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:A common theme in medical microbiology is that the amount of amino acid sequence variation in proteins that are targets of the host immune system greatly exceeds that found in metabolic enzymes or other housekeeping proteins. Twenty-four Mycobacterium tuberculosis genes coding for targets of the host immune system wer...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.039024
更新日期：2005-09-01 00:00:00
abstract：:Recessive mutant alleles at the autosomal dpy-21 locus of C. elegans cause a dumpy phenotype in XX animals but not in XO animals. This dumpy phenotype is characteristic of X chromosome aneuploids with higher than normal X to autosome ratios and is proposed to result from overexpression of X-linked genes. We have isola...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Accumulation of RNA was measured in adult males of two genotypes: car bb/Ybb- and car bb/YbbSuVar-5. The two genotypes have similar amounts of rDNA, which is reduced in comparison to wild type (CLARK, STRAUSBAUGH and KIEFER 1977). Although genotypically bobbed, car bb/YbbSuVar-5 flies have a wild-type phenotype; car b...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:Studies of transcriptional gene silencing in Drosophila melanogaster suggest that most of chromosome 4 resembles pericentric heterochromatin. However, some modifiers of position-effect variegation, including chromosome 4 dosage and loss of SU(VAR)3-9, have different effects on silencing in pericentric vs. distal arm c...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.066407
更新日期：2007-03-01 00:00:00
abstract：:Infantile neuronal ceroid lipofuscinosis (INCL) is a pediatric neurodegenerative disease caused by mutations in the human CLN1 gene. CLN1 encodes palmitoyl-protein thioesterase 1 (PPT1), suggesting an important role for the regulation of palmitoylation in normal neuronal function. To further elucidate Ppt1 function, w...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.067983
更新日期：2007-05-01 00:00:00
abstract：:We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.179093
更新日期：2015-11-01 00:00:00
abstract：:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a populatio...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301592
更新日期：2018-12-01 00:00:00
abstract：:Using a new model of isoalleles, extensive Monte Carlo experiments were performed to examine the pattern of allelic distribution in a finite population. In this model it was assumed that the set of allelic states is represented by discrete points on a one-dimensional lattice and that change of state by mutation occurs...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-03-01 00:00:00
abstract：:Enhancer of split [E(spl)] is one of the neurogenic loci of Drosophila and, as such, is required for normal segregation of neural and epidermal cell progenitors. Genetic observations indicate that the E(spl) locus is in fact a gene complex comprising a cluster of related genes and that other genes of the region are al...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:We test models for the evolution of helical regions of RNA sequences, where the base pairing constraint leads to correlated compensatory substitutions occurring on either side of the pair. These models are of three types: 6-state models include only the four Watson-Crick pairs plus GU and UG; 7-state models include a ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
