Genetic modulation of RNA metabolism in Drosophila. IV. Measurement of rats of RNA synthesis by density labeling.

abstract：:Temporally spaced genetic data allow for more accurate inference of population genetic parameters and hypothesis testing on the recent action of natural selection. In this work, we develop a novel likelihood-based method for jointly estimating selection coefficient and allele age from time series data of allele freque...

journal_title：Genetics

authors： He Z,Dai X,Beaumont M,Yu F

更新日期：2020-10-01 00:00:00

abstract：:Advances in medicine, agriculture, and an understanding of evolution depend on resolving the genetic architecture of quantitative traits, which is challenging since variation for complex traits is caused by multiple interacting quantitative trait loci (QTL) with small and conditional effects. Here, we show that the ke...

journal_title：Genetics

authors： Robin C,Lyman RF,Long AD,Langley CH,Mackay TF

更新日期：2002-09-01 00:00:00

abstract：:Ras1 GTPase is the Schizosaccharomyces pombe homolog of the mammalian Ha-Ras proto-oncoprotein. Ras1 interacts with Scd1 (aka Ral1), a presumptive guanine nucleotide exchange factor for Cdc42sp, to control organization of the cytoskeleton. In this study, we demonstrated that the scd1 deletion (scd1Delta) induced hyper...

journal_title：Genetics

authors： Li YC,Chen CR,Chang EC

更新日期：2000-11-01 00:00:00

abstract：:This study examines the intrinsic fitness burden associated with RNA polymerase (rpoB) mutations conferring rifampin resistance in Escherichia coli K12 (MG1655) and explores the nature of adaptation to the costs of resistance. Among 28 independent Rif(r) mutants, the per-generation fitness burden (in the absence of ri...

journal_title：Genetics

authors： Reynolds MG

更新日期：2000-12-01 00:00:00

abstract：:We present a genetic map based on microsatellite polymorphisms for the African human malaria vector, Anopheles gambiae. Polymorphisms in laboratory strains were detected for 89% of the tested microsatellite markers. Genotyping was performed for individual mosquitos from 13 backcross families that included 679 progeny....

journal_title：Genetics

authors： Zheng L,Benedict MQ,Cornel AJ,Collins FH,Kafatos FC

更新日期：1996-06-01 00:00:00

abstract：:Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosom...

journal_title：Genetics

authors： Brumby A,Secombe J,Horsfield J,Coombe M,Amin N,Coates D,Saint R,Richardson H

更新日期：2004-09-01 00:00:00

abstract：:Genetic analyses of nine traits associated with stem water-soluble carbohydrate (SWSC) accumulation and remobilization at grain-filling period under drought stress (DS) and well-watered (WW) conditions were undertaken using doubled haploid lines (DHLs) derived from two Chinese common wheat cultivars. Some significantl...

journal_title：Genetics

authors： Yang DL,Jing RL,Chang XP,Li W

更新日期：2007-05-01 00:00:00

abstract：:The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...

journal_title：Genetics

authors： Cooper MT,Conant AW,Kennison JA

更新日期：2010-07-01 00:00:00

abstract：:RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the...

journal_title：Genetics

authors： Perrimon N,Mathey-Prevot B

更新日期：2007-01-01 00:00:00

abstract：:Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 are asymmetrically localized to the cytoplasmic face and have distinct functional domains: a phenylalanine-glycine (FG) re...

journal_title：Genetics

authors： Adams RL,Terry LJ,Wente SR

更新日期：2014-08-01 00:00:00

abstract：:In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...

journal_title：Genetics

authors： Weissman DB,Hallatschek O

更新日期：2014-04-01 00:00:00

abstract：:The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...

journal_title：Genetics

authors： Wu CI

更新日期：1983-11-01 00:00:00

abstract：:Segregation distorter (SD) chromosomes are preferentially transmitted to offspring from heterozygous SD/SD(+) males owing to the induced dysfunction of the SD(+)-bearing sperm. This phenomenon involves at least two major loci: the Sd locus whose presence is necessary for distortion to occur and the Rsp locus which act...

journal_title：Genetics

authors： Brittnacher JG,Ganetzky B

更新日期：1983-04-01 00:00:00

abstract：:We discuss the conceptual conflict between a slow series of gene substitutions as the mechanism of evolutionary change, and the apparent need for rapid and coordinated changes at many loci simultaneously in producing complex adaptations. To improve on the limitations of classical theory and accommodate the enormous am...

journal_title：Genetics

authors： Koehler DO,Whitten BL,Gregg TG

更新日期：1980-03-01 00:00:00

abstract：:The parasitoid wasp Nasonia represents a genus of four species that is emerging as a powerful genetic model system that has made and will continue to make important contributions to our understanding of evolutionary biology, development, ecology, and behavior. Particularly powerful are the haplodiploid genetics of the...

journal_title：Genetics

authors： Lynch JA

更新日期：2015-04-01 00:00:00

abstract：:Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), includi...

journal_title：Genetics

authors： Phillips JP,Forrest HS,Kulkarni AD

更新日期：1973-01-01 00:00:00

abstract：:The degree to which genomic architecture varies across space and time is central to the evolution of genomes in response to natural selection. Bulked-segregant mapping combined with pooled sequencing provides an efficient means to estimate the effect of genetic variants on quantitative traits. We develop a novel likel...

journal_title：Genetics

authors： Monnahan PJ,Kelly JK

更新日期：2017-07-01 00:00:00

abstract：:Predictions for the rate of inbreeding (DeltaF) in populations with discrete generations undergoing selection on best linear unbiased prediction (BLUP) of breeding value were developed. Predictions were based on the concept of long-term genetic contributions using a recently established relationship between expected c...

journal_title：Genetics

authors： Bijma P,Woolliams JA

更新日期：2000-09-01 00:00:00

abstract：:Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...

journal_title：Genetics

authors： Zhang S,Binari R,Zhou R,Perrimon N

更新日期：2010-04-01 00:00:00

abstract：:Germ cell specification as sperm or oocyte is an ancient cell fate decision, but its molecular regulation is poorly understood. In Caenorhabditis elegans, the FOG-1 and FOG-3 proteins behave genetically as terminal regulators of sperm fate specification. Both are homologous to well-established RNA regulators, suggesti...

journal_title：Genetics

authors： Noble DC,Aoki ST,Ortiz MA,Kim KW,Verheyden JM,Kimble J

更新日期：2016-01-01 00:00:00

abstract：:The Saccharomyces cerevisiae nuclear gene RPM2 encodes a component of the mitochondrial tRNA-processing enzyme RNase P. Cells grown on fermentable carbon sources do not require mitochondrial tRNA processing activity, but still require RPM2, indicating an additional function for the Rpm2 protein. RPM2-null cells arrest...

journal_title：Genetics

authors： Lutz MS,Ellis SR,Martin NC

更新日期：2000-03-01 00:00:00

abstract：:During the first weeks of human immunodeficiency virus-1 (HIV-1) infection, cytotoxic T-lymphocytes (CTLs) select for multiple escape mutations in the infecting HIV population. In recent years, methods that use escape mutation data to estimate rates of HIV escape have been developed, thereby providing a quantitative f...

journal_title：Genetics

authors： Leviyang S

更新日期：2013-07-01 00:00:00

abstract：:In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...

journal_title：Genetics

authors： Golic MM,Golic KG

更新日期：1996-05-01 00:00:00

abstract：:Studies of genetic variation at allozyme loci, assumed to be selectively neutral, have provided valuable insights into the genetic structure of numerous populations. The degree to which population structure of allozyme variation reflects that of quantitative traits, however, is not well resolved. Here, we compare esti...

journal_title：Genetics

authors： Podolsky RH,Holtsford TP

更新日期：1995-06-01 00:00:00

abstract：:New rudimentary (r) mutants have been isolated following mutagenesis with ethyl methanesulfonate (r(LE)), ICR-170 (r(LI)) and X rays (r(LX)). From wing phenotype measurements on homoallelic females, it has been shown that the r(LE) mutant series includes several leaky alleles, as well as alleles that produce moderate ...

journal_title：Genetics

authors： Rawls JM,Porter LA

更新日期：1979-09-01 00:00:00

abstract：:The X chromosome requires special treatment in the mapping of quantitative trait loci (QTL). However, most QTL mapping methods, and most computer programs for QTL mapping, have focused exclusively on autosomal loci. We describe a method for appropriate treatment of the X chromosome for QTL mapping in experimental cros...

journal_title：Genetics

authors： Broman KW,Sen S,Owens SE,Manichaikul A,Southard-Smith EM,Churchill GA

更新日期：2006-12-01 00:00:00

abstract：:We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...

journal_title：Genetics

authors： Guan Y

更新日期：2014-03-01 00:00:00

abstract：:Homolog recombination and unequal sister chromatid recombination were monitored in rad1-1/rad1-1 diploid yeast cells deficient for excision repair, and in control cells, RAD1/rad1-1, after exposure to UV irradiation. In a rad1-1/rad1-1 diploid, UV irradiation stimulated much more sister chromatid recombination relativ...

journal_title：Genetics

authors： Kadyk LC,Hartwell LH

更新日期：1993-03-01 00:00:00

abstract：:The rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage th...

journal_title：Genetics

authors： Xia X

更新日期：1996-11-01 00:00:00

abstract：:Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome, is largely similar across eukaryotes ranging from unicellular protists to vertebrates. Conversely, this bias in housekeeping genes and in highly expressed genes has a remarkable inverse relationship with species gener...

journal_title：Genetics

authors： Subramanian S

更新日期：2008-04-01 00:00:00