Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae.

abstract：:In this paper we study the process of allele frequency change in finite populations with overlapping generations with the purpose of evaluating the possibility of estimating the effective size from observations of temporal frequency shifts of selectively neutral alleles. Focusing on allele frequency changes between su...

journal_title：Genetics

authors： Jorde PE,Ryman N

更新日期：1995-02-01 00:00:00

abstract：:The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...

journal_title：Genetics

authors： Daetwyler HD,Calus MP,Pong-Wong R,de Los Campos G,Hickey JM

更新日期：2013-02-01 00:00:00

abstract：:Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...

journal_title：Genetics

authors： Grognet P,Bidard F,Kuchly C,Tong LC,Coppin E,Benkhali JA,Couloux A,Wincker P,Debuchy R,Silar P

更新日期：2014-05-01 00:00:00

abstract：:The centromere is essential for proper segregation and inheritance of genetic information. Centromeres are generally regulated to occur exactly once per chromosome; failure to do so leads to chromosome loss or damage and loss of linked genetic material. The mechanism for faithful regulation of centromere activity and ...

journal_title：Genetics

authors： Maggert KA,Karpen GH

更新日期：2001-08-01 00:00:00

abstract：:Knowledge of multigenic family organization should provide insight into their mode of evolution. Accordingly, we characterized the 5S ribosomal gene family in the Drosophila melanogaster strain ry506. The 5S genes in this strain display a striking HindIII restriction difference compared to the "standard" D. melanogast...

journal_title：Genetics

authors： Samson ML,Wegnez M

更新日期：1988-04-01 00:00:00

abstract：:Various management strategies aim at maintaining pesticide resistance frequency under a threshold value by taking advantage of the benefit of the fitness penalty (the cost) expressed by the resistance allele outside the treated area or during the pesticide selection "off years." One method to estimate a fitness cost i...

journal_title：Genetics

authors： Roux F,Giancola S,Durand S,Reboud X

更新日期：2006-06-01 00:00:00

abstract：:Using a new model of isoalleles, extensive Monte Carlo experiments were performed to examine the pattern of allelic distribution in a finite population. In this model it was assumed that the set of allelic states is represented by discrete points on a one-dimensional lattice and that change of state by mutation occurs...

journal_title：Genetics

authors： Ohta T,Kimura M

更新日期：1974-03-01 00:00:00

abstract：:Clinal variation is common for enzymes in the glycolytic pathway for Drosophila melanogaster and is generally accepted as an adaptive response to different climates. Although the enzyme phosphoglucomutase (PGM) possesses several allozyme polymorphisms, it is unique in that it had been reported to show no clinal variat...

journal_title：Genetics

authors： Verrelli BC,Eanes WF

更新日期：2001-04-01 00:00:00

abstract：:Caenorhabditis elegans hermaphrodites make first sperm, then oocytes. By contrast, animals homozygous for any of six loss-of-function mutations in the gene mog-1 (for masculinization of the germ line) make sperm continuously and do not switch into oogenesis. Therefore, in mog-1 mutants, germ cells that normally would ...

journal_title：Genetics

authors： Graham PL,Kimble J

更新日期：1993-04-01 00:00:00

abstract：:Self-incompatibility (SI) is a genetic system found in some hermaphrodite plants. Recognition of pollen by pistils expressing cognate specificities at two linked genes leads to rejection of self pollen and pollen from close relatives, i.e., to avoidance of self-fertilization and inbred matings, and thus increased outc...

journal_title：Genetics

authors： Gervais CE,Castric V,Ressayre A,Billiard S

更新日期：2011-07-01 00:00:00

abstract：:A family of protein kinases regulates translation in response to different cellular stresses by phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2alpha). In yeast, an eIF-2alpha kinase, GCN2, functions in translational control in response to amino acid starvation. It is thought that uncharge...

journal_title：Genetics

authors： Sood R,Porter AC,Olsen DA,Cavener DR,Wek RC

更新日期：2000-02-01 00:00:00

abstract：:With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this ...

journal_title：Genetics

authors： Brzyski D,Peterson CB,Sobczyk P,Candès EJ,Bogdan M,Sabatti C

更新日期：2017-01-01 00:00:00

abstract：:Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...

journal_title：Genetics

authors： Sen S,Johannes F,Broman KW

更新日期：2009-04-01 00:00:00

abstract：:Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. Ubiquitin E3 ligases confer substrate specificity in this pathway, and SCF-type ligases comprise a major class of E3s. SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate rec...

journal_title：Genetics

authors： Gilkerson J,Hu J,Brown J,Jones A,Sun TP,Callis J

更新日期：2009-03-01 00:00:00

abstract：:Sexual reproduction and recombination are important for maintaining a stable copy number of transposable elements (TEs). In sexual populations, elements can be contained by purifying selection against host carriers with higher element copy numbers; however, in the absence of sex and recombination, asexual populations ...

journal_title：Genetics

authors： Dolgin ES,Charlesworth B

更新日期：2006-10-01 00:00:00

abstract：:Our previous work suggests that the Nhp6 HMGB protein stimulates RNA polymerase II transcription via the TATA-binding protein TBP and that Nhp6 functions in the same functional pathway as the Gcn5 histone acetyltransferase. In this report we examine the genetic relationship between Nhp6 and Gcn5 with the Mot1 and Ccr4...

journal_title：Genetics

authors： Biswas D,Yu Y,Mitra D,Stillman DJ

更新日期：2006-02-01 00:00:00

abstract：:In Arabidopsis thaliana, DICER-LIKE 1 and DICER-LIKE 3 are involved in the generation of small RNAs. Double mutants between dicer-like 1 and dicer-like 3 exhibit a delay in flowering that is caused by increased expression of the floral repressor FLOWERING LOCUS C. This delayed-flowering phenotype is similar to that of...

journal_title：Genetics

authors： Schmitz RJ,Hong L,Fitzpatrick KE,Amasino RM

更新日期：2007-06-01 00:00:00

abstract：:We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) w...

journal_title：Genetics

authors： Niculita-Hirzel H,Stöck M,Perrin N

更新日期：2008-07-01 00:00:00

abstract：:Transposable element activity is repressed in the germline in animals by PIWI-interacting RNAs (piRNAs), a class of small RNAs produced by genomic loci mostly composed of TE sequences. The mechanism of induction of piRNA production by these loci is still enigmatic. We have shown that, in Drosophila melanogaster, a clu...

journal_title：Genetics

authors： Hermant C,Boivin A,Teysset L,Delmarre V,Asif-Laidin A,van den Beek M,Antoniewski C,Ronsseray S

更新日期：2015-12-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection exper...

journal_title：Genetics

authors： Hillis DA,Yadgary L,Weinstock GM,Pardo-Manuel de Villena F,Pomp D,Fowler AS,Xu S,Chan F,Garland T Jr

更新日期：2020-11-01 00:00:00

abstract：:Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosom...

journal_title：Genetics

authors： Brumby A,Secombe J,Horsfield J,Coombe M,Amin N,Coates D,Saint R,Richardson H

更新日期：2004-09-01 00:00:00

abstract：:Two replications of a complete diallel cross experiment were performed among four partially inbred lines of mice. These inbred lines originated from a random-bred ICR strain and were produced by 12 generations of full sibbing (F congruent to 92%). Individual body weight was recorded for each animal at 12, 21, 42 and 5...

journal_title：Genetics

authors： Jamison MG,White JM,Vinson WE,Hinkelmann K

更新日期：1975-10-01 00:00:00

abstract：:The integrin family of cell surface receptors mediates cell-substrate and cell-to-cell adhesion and transmits intracellular signals. In Drosophila there is good evidence for an adhesive role of integrins, but evidence for integrin signalling has remained elusive. Each integrin is an alphabeta heterodimer, and the Dros...

journal_title：Genetics

authors： Bloor JW,Brown NH

更新日期：1998-03-01 00:00:00

abstract：:The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor (Egfrtm1Mag) in mice is strongly dependent on genetic background. Initial attempts to genetically map background modifiers using Swiss-derived, outbred CD-1 mice were unsuccessful. To investigate the genetic archit...

journal_title：Genetics

authors： Strunk KE,Amann V,Threadgill DW

更新日期：2004-08-01 00:00:00

abstract：:The L-shaped distribution of estimated QTL effects (R(2)) has long been reported. We recently showed that a metabolic mechanism could account for this phenomenon. But other nonexclusive genetic or nongenetic causes may contribute to generate such a distribution. Using analysis and simulations of an additive genetic mo...

journal_title：Genetics

authors： Bost B,de Vienne D,Hospital F,Moreau L,Dillmann C

更新日期：2001-04-01 00:00:00

abstract：:The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its evolutionary hist...

journal_title：Genetics

authors： Andolfatto P,Wall JD,Kreitman M

更新日期：1999-11-01 00:00:00

abstract：:Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 are asymmetrically localized to the cytoplasmic face and have distinct functional domains: a phenylalanine-glycine (FG) re...

journal_title：Genetics

authors： Adams RL,Terry LJ,Wente SR

更新日期：2014-08-01 00:00:00

abstract：:Mutations in arg-13 result in slow growth in minimal medium and can suppress mutations in carbamyl phosphate synthase-aspartate carbamyl transferase within the pyrimidine pathway; the exact biochemical function of the gene product is unknown. To understand the role of arg-13 in arginine metabolism, cosmids rescuing gr...

journal_title：Genetics

authors： Liu Q,Dunlap JC

更新日期：1996-07-01 00:00:00

abstract：:Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (...

journal_title：Genetics

authors： Funkhouser SA,Vazquez AI,Steibel JP,Ernst CW,Los Campos G

更新日期：2020-05-01 00:00:00