Abstract:
:We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) within their glutamine-rich central part. These changes have the potential to affect the conformation of the Mediator complex and to activate genes in a sex-specific way and might thus represent the first steps toward the acquisition of a male-specific function. Alternatively, they might result from an ancestral neutral polymorphism, with different alleles picked by chance on the X and Y chromosomes when MED15 was trapped in the nonrecombining segment.
journal_name
Geneticsjournal_title
Geneticsauthors
Niculita-Hirzel H,Stöck M,Perrin Ndoi
10.1534/genetics.108.090746subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1721-3issue
3eissn
0016-6731issn
1943-2631pii
genetics.108.090746journal_volume
179pub_type
杂志文章相关文献
GENETICS文献大全abstract::During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this "Compact" phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this li...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Mutations affecting the self-incompatibility response of Nicotiana alata were generated by irradiation. Mutants in the M1 generation were selected on the basis of pollen tube growth through an otherwise incompatible pistil. Twelve of the 18 M1 plants obtained from the mutagenesis screen were self-compatible. Eleven se...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::Three hundred and fifteen kilobases of DNA from the rosy-Ace region on chromosome 3R of D. melanogaster have previously been cloned and extensively characterized. We describe the isolation of nine new deficiency mutants that break within the 315-kb interval. The position of these breakpoints on the DNA map was determi...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The Genetics Society of America's (GSA) Edward Novitski Prize is awarded to researchers who have solved challenging problems in genetics through experiments that demonstrate exceptional creativity and ingenuity. Job Dekker of the University of Massachusetts Medical School has been selected for the 2018 award in recogn...
journal_title:Genetics
pub_type: 传,历史文章,杂志文章
doi:10.1534/genetics.118.301641
更新日期:2018-11-01 00:00:00
abstract::Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmica...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.107.088658
更新日期:2008-03-01 00:00:00
abstract::Neural ganglia of wild type third-instar larvae of Drosophila melanogaster were incubated for 13 hours at various concentrations of BUdR (1, 3, 9, 27 micrograms/ml). Metaphases were collected with colchicine, stained with Hoechst 33258, and scored under a fluorescence microscope. Metaphases in which the sister chromat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract::Using conditional probabilities and moment-generating matrices, I derived approximate algebraic equations that give expectations of gene frequency, population mean, gene frequency variance within lines, or heterozygosity, and gene frequency variance between lines, or drift, for repeated cycles of recurrent selection i...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract::Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hypothesis is that th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178079
更新日期:2015-10-01 00:00:00
abstract::The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.117.300167
更新日期:2018-06-01 00:00:00
abstract::The accumulation of slightly deleterious mutations in populations leads to the buildup of a genetic load and can cause the extinction of populations of small size. Mutation-accumulation experiments have been used to study this process in a wide variety of organisms, yet the exact mutational underpinnings of genetic lo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.066142
更新日期:2007-01-01 00:00:00
abstract::For multiallelic loci, standard measures of linkage disequilibrium provide an incomplete description of the correlation of variation at two loci, especially when there are different numbers of alleles at the two loci. We have developed a complementary pair of conditional asymmetric linkage disequilibrium (ALD) measure...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165266
更新日期:2014-09-01 00:00:00
abstract::Twelve mutations affecting nuclear migration, a major developmental phase in Schizophyllum commune, display a complex pattern of complementation and recombination. They are expressed only when a genetic factor controlling this phase of development, the B incompatibility factor, is operative. All twelve mutations are l...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::This paper studies the properties of a new class of demographic parameters for age-structured populations and analyzes the effect of natural selection on these parameters. Two new demographic variables are introduced: the entropy of a population and the reproductive potential. The entropy of a population measures the ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::Escherichia coli K12 does not metabolize beta-glucosides such as arbutin and salicin because of lack of expression of the bglBSRC operon, which contains structural genes for transport (bglC) and hydrolysis (bglB) of phospho-beta-glucosides. Mutants carrying lesions in the cis-acting regulatory site bglR metabolize bet...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.113183
更新日期:2010-03-01 00:00:00
abstract::We study the mechanisms that guide the formation and maintenance of the highly ordered actin-myosin cytoskeleton in striated muscle. The UNC-82 kinase of Caenorhabditis elegans is orthologous to mammalian kinases ARK5/NUAK1 and SNARK/NUAK2. UNC-82 localizes to the M-line, and is required for proper organization of thi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.193029
更新日期:2017-03-01 00:00:00
abstract::The S-M checkpoint ensures that entry into mitosis is dependent on completion of DNA replication. In the fission yeast Schizosaccharomyces pombe, the SM checkpoint mutant cdc2-3w is thought to be defective in receiving the checkpoint signal. To isolate genes that function in the checkpoint pathway, we screened an S. p...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract::We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Four genes encoding the major egg yolk polypeptides of the Mediterranean fruit fly Ceratitis capitata, vitellogenins 1 and 2 (VG1 and VG2), were cloned, characterized and partially sequenced. The genes are located on the same region of chromosome 5 and are organized in pairs, each encoding the two polypeptides on oppo...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Resolving the mechanistic and genetic bases of reproductive barriers between species is essential to understanding the evolutionary forces that shape speciation. Intrinsic hybrid incompatibilities are often treated as fixed between species, yet there can be considerable variation in the strength of reproductive isolat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.300840
更新日期:2018-07-01 00:00:00
abstract::Determining parentage is a fundamental problem in biology and in applications such as identifying pedigrees. Difficulties inferring parentage derive from extensive inbreeding within the population, whether natural or planned; using an insufficient number of hypervariable loci; and from allele mismatches caused by muta...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::A consensus map for loblolly pine (Pinus taeda L.) was constructed from the integration of linkage data from two unrelated three-generation outbred pedigrees. The progeny segregation data from restriction fragment length polymorphism, random amplified polymorphic DNA, and isozyme genetic markers from each pedigree wer...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::RNA transcribed from the Saccharomyces cerevisiae retrotransposon Ty1 accumulates to a high level in mitotically growing haploid cells, yet transposition occurs at very low frequencies. The product of reverse transcription is a linear double-stranded DNA molecule that reenters the genome by either Ty1-integrase-mediat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Protein E, the lysis protein of bacteriophage phiX174, is a specific inhibitor of MraY, the phospho-MurNAc-pentapeptide translocase that catalyzes the synthesis of lipid I in the conserved pathway for peptidoglycan biosynthesis. The original evidence for this inhibition was the isolation of two spontaneous E-resistanc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.093443
更新日期:2008-11-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) are used widely for detecting quantitative trait loci, or for searching for causal variants of diseases. Nevertheless, structural variations such as copy-number variants (CNVs) represent a large part of natural genetic diversity, and contribute significantly to trait variation. N...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302881
更新日期:2020-03-01 00:00:00
abstract::Recombination in mammalian cells is thought to involve both reciprocal and nonreciprocal modes of exchange, although rigorous proof is lacking due to the inability to recover all products of an exchange. To investigate further the relationship between these modes of exchange, we have analyzed intrachromosomal recombin...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract::A two-locus model is used to analyze the effectiveness of a mixture of insecticides in delaying resistance, compared to the use of the insecticides singly. The effects of factors such as recombination, effective dominance, initial value of allele frequencies and initial value of linkage disequilibrium are considered. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.300977
更新日期:2018-06-01 00:00:00
abstract::Fisher's geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic traits, it provides a simple mechanism for the emergence of genotypic epistasis from...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.199497
更新日期:2017-06-01 00:00:00
abstract::Arabidopsis seedlings repair UV-induced DNA damage via light-dependent and independent pathways. The mechanism of the "dark repair" pathway is still unknown. To determine the number of genes required for dark repair and to investigate the substrate-specificity of this process we isolated mutants with enhanced sensitiv...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00