Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast.

abstract：:We found that heterozygous mutant alleles of E(Pc) and esc increased homologous recombination from an allelic template in somatic cells in a P-element-induced double-strand break repair assay. Flies heterozygous for mutant alleles of these genes showed increased genome stability and decreased levels of apoptosis in im...

journal_title：Genetics

authors： Holmes AM,Weedmark KA,Gloor GB

更新日期：2006-04-01 00:00:00

abstract：:A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired with marked inversion chromosomes. Mutations resulting in reductions of viability of varying magnitude short of complete le...

journal_title：Genetics

authors： Kidwell MG,Kidwell JF,Nei M

更新日期：1973-09-01 00:00:00

abstract：:The DNA-binding protein encoded by the zeste gene of Drosophila activates transcription and mediates interchromosomal interactions such as transvection. The mutant protein encoded by the zeste1 (z1) allele retains the ability to support transvection, but represses white. Similar to transvection, repression requires Ze...

journal_title：Genetics

authors： Rosen C,Dorsett D,Jack J

更新日期：1998-04-01 00:00:00

abstract：:The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediat...

journal_title：Genetics

authors： Ekechukwu MC,Oberste DJ,Fane BA

更新日期：1995-08-01 00:00:00

abstract：:Fossil evidence links human ancestry with populations that evolved from modern gracile morphology in Africa 130,000-160,000 years ago. Yet fossils alone do not provide clear answers to the question of whether the ancestors of all modern Homo sapiens comprised a single African population or an amalgamation of distinct ...

journal_title：Genetics

authors： Garrigan D,Mobasher Z,Kingan SB,Wilder JA,Hammer MF

更新日期：2005-08-01 00:00:00

abstract：:The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...

journal_title：Genetics

authors： Polley SR,Fay DS

更新日期：2012-08-01 00:00:00

abstract：:A Plasmodium-refractory strain of Anopheles gambiae melanotically encapsulates many species of Plasmodium, whereas wild-type mosquitoes are usually susceptible. This encapsulation trait can also be observed by studying the response of refractory and susceptible strains to intrathoracically injected CM-Sephadex beads. ...

journal_title：Genetics

authors： Gorman MJ,Severson DW,Cornel AJ,Collins FH,Paskewitz SM

更新日期：1997-07-01 00:00:00

abstract：:Type III galactosemia is a metabolic disorder caused by reduced activity of UDP-galactose-4-epimerase, which participates in galactose metabolism and the generation of various UDP-sugar species. We characterized gale-1 in Caenorhabditis elegans and found that a complete loss-of-function mutation is lethal, as has been...

journal_title：Genetics

authors： Brokate-Llanos AM,Monje JM,Murdoch Pdel S,Muñoz MJ

更新日期：2014-12-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...

journal_title：Genetics

authors： Altschuler MI,Bruns PJ

更新日期：1984-03-01 00:00:00

abstract：:Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...

journal_title：Genetics

authors： Shaw RG,Platenkamp GA,Shaw FH,Podolsky RH

更新日期：1995-01-01 00:00:00

abstract：:Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...

journal_title：Genetics

authors： Hofnung M

更新日期：1974-02-01 00:00:00

abstract：:The TATA-binding protein (TBP) is composed of a highly conserved core domain sufficient for TATA-element binding and preinitiation complex formation as well as a highly divergent N-terminal region that is dispensable for yeast cell viability. In vitro, removal of the N-terminal region domain enhances TBP-TATA associat...

journal_title：Genetics

authors： Lee M,Struhl K

更新日期：2001-05-01 00:00:00

abstract：:Sex differences occur in most species and affect a variety of biological traits including morphology, behavior, and life history. The nematode Caenorhabditis elegans exists as a population of self-fertile hermaphrodites with occasional males, which differ anatomically and behaviorally from hermaphrodites. Here we show...

journal_title：Genetics

authors： van den Berg MC,Woerlee JZ,Ma H,May RC

更新日期：2006-06-01 00:00:00

abstract：:Directed open reading frame (ORF) disruption and a serial selection technique in Escherichia coli and the extremely thermophilic archaeon Sulfolobus solfataricus allowed the identification of otherwise cryptic crucial and noncrucial viral open reading frames in the genome of the archaeal virus SSV1. It showed that the...

journal_title：Genetics

authors： Stedman KM,Schleper C,Rumpf E,Zillig W

更新日期：1999-08-01 00:00:00

abstract：:Four species of the Hawaiian Drosophila planitibia subgroup which are homosequential in their polytene chromosomes are resident on the islands of Molokai, Maui and Hawaii. Comparisons of DNA sequence divergence in these four have been made by hybridization of total single-copy radiolabeled tracer DNA from each of the ...

journal_title：Genetics

authors： Hunt JA,Carson HL

更新日期：1983-06-01 00:00:00

abstract：:Zymograms were analyzed of a number of Triticum aestivum derivatives which incorporated a segment of the Aegilops umbellulata chromosome bearing resistance to leaf rust. Evidence has been presented which suggests that genes involved in the production of two peroxidases and a single peptidase are located on the short a...

journal_title：Genetics

authors： Macdonald T,Smith HH

更新日期：1972-09-01 00:00:00

abstract：:The identification of a second structural gene mutation at the feline arylsulfatase B locus (MPS VIb) provided the opportunity to investigate the expression of allelism by characterization of the residual enzymatic activity in feline mucopolysaccharidosis VI, an animal analogue of human Maroteaux-Lamy syndrome. Mating...

journal_title：Genetics

authors： McGovern MM,Mandell N,Haskins M,Desnick RJ

更新日期：1985-08-01 00:00:00

abstract：:Hybrid sterility is a common form of reproductive isolation between nascent species. Although hybrid sterility is routinely documented and genetically dissected in speciation studies, its developmental basis is rarely examined, especially in generations beyond the F1 generation. To identify phenotypic and genetic dete...

journal_title：Genetics

authors： Schwahn DJ,Wang RJ,White MA,Payseur BA

更新日期：2018-12-01 00:00:00

abstract：:Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, su...

journal_title：Genetics

authors： Ard R,Allshire RC,Marquardt S

更新日期：2017-10-01 00:00:00

abstract：:Grain yield is a major goal for the improvement of durum wheat, particularly in drought-prone areas. In this study, the genetic basis of grain yield (GY), heading date (HD), and plant height (PH) was investigated in a durum wheat population of 249 recombinant inbred lines evaluated in 16 environments (10 rainfed and 6...

journal_title：Genetics

authors： Maccaferri M,Sanguineti MC,Corneti S,Ortega JL,Salem MB,Bort J,DeAmbrogio E,del Moral LF,Demontis A,El-Ahmed A,Maalouf F,Machlab H,Martos V,Moragues M,Motawaj J,Nachit M,Nserallah N,Ouabbou H,Royo C,Slama A,Tubero

更新日期：2008-01-01 00:00:00

abstract：:Stress-induced mutagenesis is a collection of mechanisms observed in bacterial, yeast, and human cells in which adverse conditions provoke mutagenesis, often under the control of stress responses. Control of mutagenesis by stress responses may accelerate evolution specifically when cells are maladapted to their enviro...

journal_title：Genetics

authors： Galhardo RS,Do R,Yamada M,Friedberg EC,Hastings PJ,Nohmi T,Rosenberg SM

更新日期：2009-05-01 00:00:00

abstract：:We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the fir...

journal_title：Genetics

authors： Tomasini M,Peischl S

更新日期：2018-07-01 00:00:00

abstract：:Mutants of Neurospora crassa have been isolated that lack the repressible alkaline phosphatase, but, unlike nuc-1 and nuc-2 mutants, are able to make the repressible acid phosphatase and the repressible phosphate permease under conditions of derepression (phosphate deprivation). The new mutants, called pho-2, map in L...

journal_title：Genetics

authors： Gleason MK,Metzenberg RL

更新日期：1974-10-01 00:00:00

abstract：:The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...

journal_title：Genetics

authors： Sanchez JC,Ollodart A,Large CRL,Clough C,Alvino GM,Tsuchiya M,Crane M,Kwan EX,Kaeberlein M,Dunham MJ,Raghuraman MK,Brewer BJ

更新日期：2019-09-01 00:00:00

abstract：:Seed component structures were grouped into maternal and offspring (embryo and endosperm) tissues to characterize a dormancy quantitative trait locus (QTL) for tissue-specific function using a marker-assisted genetic approach. The approach was devised to test if genotypic/allelic frequencies of a marker tightly linked...

journal_title：Genetics

authors： Gu XY,Turnipseed EB,Foley ME

更新日期：2008-08-01 00:00:00

abstract：:The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...

journal_title：Genetics

authors： Lessard S

更新日期：2005-09-01 00:00:00

abstract：:This work demonstrates that environmental conditions experienced by individuals can shape their development and affect the stability of genetic associations. The implication of this observation is that the environmental response may influence the evolution of traits in the wild. Here, we examined how the genetic archi...

journal_title：Genetics

authors： Robinson MR,Wilson AJ,Pilkington JG,Clutton-Brock TH,Pemberton JM,Kruuk LE

更新日期：2009-04-01 00:00:00

abstract：:Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in prognosis and survival. Assuming that the differences are attributed to subtype-specific pathways, we then...

journal_title：Genetics

authors： Li R,Campos J,Iida J

更新日期：2015-12-01 00:00:00

abstract：:The accumulation of slightly deleterious mutations in populations leads to the buildup of a genetic load and can cause the extinction of populations of small size. Mutation-accumulation experiments have been used to study this process in a wide variety of organisms, yet the exact mutational underpinnings of genetic lo...

journal_title：Genetics

authors： Soll SJ,Díaz Arenas C,Lehman N

更新日期：2007-01-01 00:00:00