Variation Associated with an AEGILOPS UMBELLULATA Chromosome Segment Incorporated in Wheat. II. Peroxidase and Leucine Aminopeptidase Isozymes.

abstract：:No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed. ...

journal_title：Genetics

authors： Chen JJ,Duan T,Single R,Mather K,Thomson G

更新日期：2005-07-01 00:00:00

abstract：:Natural selection favors alleles that increase the number of offspring produced by their carriers. But in a world that is inherently uncertain within generations, selection also favors alleles that reduce the variance in the number of offspring produced. If previous studies have established this principle, they have l...

journal_title：Genetics

authors： Mullon C,Reuter M,Lehmann L

更新日期：2014-01-01 00:00:00

abstract：:The value of molecular markers and pedigree records, separately or in combination, to assist in the management of conserved populations has been tested. The general strategy for managing the population was to optimize contributions of parents to the next generation for minimizing the global weighted coancestry. Strate...

journal_title：Genetics

authors： Fernández J,Villanueva B,Pong-Wong R,Toro MA

更新日期：2005-07-01 00:00:00

abstract：:A likelihood ratio test is presented for comparing rates of evolutionary change in the paths of descent leading to two species. The test is compared to previous relative rate tests based on variances of estimated numbers of base substitutions. The likelihood approach allows for different transversion and transition ra...

journal_title：Genetics

authors： Muse SV,Weir BS

更新日期：1992-09-01 00:00:00

abstract：:In both pedigree linkage studies and in population-based association studies there has been much interest in the use of modern dense genetic marker data to infer segments of gene identity by descent (ibd) among individuals not known to be related, to increase power and resolution in localizing genes affecting complex ...

journal_title：Genetics

authors： Brown MD,Glazner CG,Zheng C,Thompson EA

更新日期：2012-04-01 00:00:00

abstract：:We consider resequencing studies of associated loci and the problem of prioritizing sequence variants for functional follow-up. Working within the multivariate linear regression framework helps us to account for the joint effects of multiple genes; and adopting a Bayesian approach leads to posterior probabilities that...

journal_title：Genetics

authors： Stell L,Sabatti C

更新日期：2016-02-01 00:00:00

abstract：:The ability of autonomously replicating plasmids to recombine in mammalian cells was investigated. Two deletion plasmids of the eukaryotic-prokaryotic shuttle vector pSV2neo were cotransfected into transformed monkey COS cells. Examination of the low molecular weight DNA isolated after 48 hr of incubation revealed tha...

journal_title：Genetics

authors： Ayares D,Spencer J,Schwartz F,Morse B,Kucherlapati R

更新日期：1985-10-01 00:00:00

abstract：:The Snf1 protein kinase of the glucose signaling pathway in Saccharomyces cerevisiae is regulated by an autoinhibitory interaction between the regulatory and catalytic domains of Snf1p. Transitions between the autoinhibited and active states are controlled by an upstream kinase and the Reg1p-Glc7p protein phosphatase ...

journal_title：Genetics

authors： Kuchin S,Vyas VK,Kanter E,Hong SP,Carlson M

更新日期：2003-02-01 00:00:00

abstract：:The cdc19+ gene encodes an essential member of the MCM family of replication proteins in Schizosaccharomyces pombe. We have examined the structure and function of the Cdc19p protein using molecular and genetic approaches. We find that overproduction of wild-type Cdc19p in wild-type cells has no effect, but cdc19-P1 mu...

journal_title：Genetics

authors： Forsburg SL,Sherman DA,Ottilie S,Yasuda JR,Hodson JA

更新日期：1997-11-01 00:00:00

abstract：:A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired with marked inversion chromosomes. Mutations resulting in reductions of viability of varying magnitude short of complete le...

journal_title：Genetics

authors： Kidwell MG,Kidwell JF,Nei M

更新日期：1973-09-01 00:00:00

abstract：:Plant breeders make selection decisions based on multiple traits, such as yield, plant height, flowering time, and disease resistance. A commonly used approach in multi-trait genomic selection is index selection, which assigns weights to different traits relative to their economic importance. However, classical index ...

journal_title：Genetics

authors： Moeinizade S,Kusmec A,Hu G,Wang L,Schnable PS

更新日期：2020-08-01 00:00:00

abstract：:Condensins are evolutionarily conserved protein complexes that are required for chromosome segregation during cell division and genome organization during interphase. In Caenorhabditis elegans, a specialized condensin, which forms the core of the dosage compensation complex (DCC), binds to and represses X chromosome t...

journal_title：Genetics

authors： Street LA,Morao AK,Winterkorn LH,Jiao CY,Albritton SE,Sadic M,Kramer M,Ercan S

更新日期：2019-07-01 00:00:00

abstract：:Repair replication of DNA has been studied in first instar larvae of Drosophila melanogaster with isopycnic centrifugation techniques. Larvae were fed BUdR, FUdR, streptomycin, penicillin, and Fungazone for two to four hours prior to exposure to UV, X-rays, MMS, or EMS. Feeding was continued for four hours in the pres...

journal_title：Genetics

authors： Boyd JB,Presley JM

更新日期：1974-08-01 00:00:00

abstract：:A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these th...

journal_title：Genetics

authors： Rebaï A,Goffinet B,Mangin B

更新日期：1994-09-01 00:00:00

abstract：:Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are...

journal_title：Genetics

authors： Thomas PE,Hutton JJ,Taylor BA

更新日期：1973-08-01 00:00:00

abstract：:The idealized individual in many fungal species is a haploid self-sterile hermaphrodite that may be propagated by asexually produced spores or that may reproduce sexually. In field populations, polymorphism occurs for female-sterile/hermaphrodite status, and female-sterile mutants, which function only as males during ...

journal_title：Genetics

authors： Leslie JF,Klein KK

更新日期：1996-10-01 00:00:00

abstract：:We examined mutations that disrupt muscle activation in Caenorhabditis elegans. Fifteen of 17 of these genes were identified previously and we describe new mutations in three of them. We also describe mutations in two new genes, exp-3 and exp-4. We assessed the degree of defect in pharyngeal, body-wall, egg-laying, an...

journal_title：Genetics

authors： Reiner DJ,Weinshenker D,Thomas JH

更新日期：1995-11-01 00:00:00

abstract：:We test models for the evolution of helical regions of RNA sequences, where the base pairing constraint leads to correlated compensatory substitutions occurring on either side of the pair. These models are of three types: 6-state models include only the four Watson-Crick pairs plus GU and UG; 7-state models include a ...

journal_title：Genetics

authors： Savill NJ,Hoyle DC,Higgs PG

更新日期：2001-01-01 00:00:00

abstract：:Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...

journal_title：Genetics

authors： Saitoh K,Onishi K,Mikami I,Thidar K,Sano Y

更新日期：2004-10-01 00:00:00

abstract：:Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...

journal_title：Genetics

authors： Zhang S,Binari R,Zhou R,Perrimon N

更新日期：2010-04-01 00:00:00

abstract：:The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...

journal_title：Genetics

authors： Tsuda M,Peyre JB,Asano T,Aigaki T

更新日期：2015-08-01 00:00:00

abstract：:Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of pro...

journal_title：Genetics

authors： Fang Q,Longo-Guess C,Gagnon LH,Mortensen AH,Dolan DF,Camper SA,Johnson KR

更新日期：2011-10-01 00:00:00

abstract：:The prune gene of Drosophila melanogaster is predicted to encode a phosphodiesterase. Null alleles of prune are viable but cause an eye-color phenotype. The abnormal wing discs gene encodes a nucleoside diphosphate kinase. Killer of prune is a missense mutation in the abnormal wing discs gene. Although it has no pheno...

journal_title：Genetics

authors： Provost E,Hersperger G,Timmons L,Ho WQ,Hersperger E,Alcazar R,Shearn A

更新日期：2006-01-01 00:00:00

abstract：:Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...

journal_title：Genetics

authors： Shaw RG,Platenkamp GA,Shaw FH,Podolsky RH

更新日期：1995-01-01 00:00:00

abstract：:In this paper we study the process of allele frequency change in finite populations with overlapping generations with the purpose of evaluating the possibility of estimating the effective size from observations of temporal frequency shifts of selectively neutral alleles. Focusing on allele frequency changes between su...

journal_title：Genetics

authors： Jorde PE,Ryman N

更新日期：1995-02-01 00:00:00

abstract：:In classical "cut-and-paste" transposition, transposons are excised from donor sites and inserted at new locations. We have identified an alternative pathway in which transposition involves the 5' end of an intact Ac element and the 3' end of a nearby terminally deleted fAc (fractured Ac). The Ac and fAc elements are ...

journal_title：Genetics

authors： Zhang J,Peterson T

更新日期：2004-08-01 00:00:00

abstract：:Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...

journal_title：Genetics

authors： Oka A,Aoto T,Totsuka Y,Takahashi R,Ueda M,Mita A,Sakurai-Yamatani N,Yamamoto H,Kuriki S,Takagi N,Moriwaki K,Shiroishi T

更新日期：2007-01-01 00:00:00

abstract：:Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression. The mutations e(y)1u1, e(y)3u1, and to a lesser extent e(y)2u1, enhance the effect of the zeste null allele zv77h. Different combinations of e(y)1u1, e(y)2u1 and e(y)3u1...

journal_title：Genetics

authors： Georgiev PG

更新日期：1994-11-01 00:00:00

abstract：:Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicidal and are somehow resurrected elsewhere in the genome. After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key real...

journal_title：Genetics

authors： Wahls WP,Davidson MK

更新日期：2011-11-01 00:00:00

abstract：:Penicillium marneffei is an opportunistic fungal pathogen of humans and the only dimorphic species identified in its genus. At 25 degrees P. marneffei exhibits true filamentous growth, while at 37 degrees P. marneffei undergoes a dimorphic transition to produce uninucleate yeast cells that divide by fission. Members o...

journal_title：Genetics

authors： Borneman AR,Hynes MJ,Andrianopoulos A

更新日期：2001-03-01 00:00:00