Abstract:
:Fossil evidence links human ancestry with populations that evolved from modern gracile morphology in Africa 130,000-160,000 years ago. Yet fossils alone do not provide clear answers to the question of whether the ancestors of all modern Homo sapiens comprised a single African population or an amalgamation of distinct archaic populations. DNA sequence data have consistently supported a single-origin model in which anatomically modern Africans expanded and completely replaced all other archaic hominin populations. Aided by a novel experimental design, we present the first genetic evidence that statistically rejects the null hypothesis that our species descends from a single, historically panmictic population. In a global sample of 42 X chromosomes, two African individuals carry a lineage of noncoding 17.5-kb sequence that has survived for >1 million years without any clear traces of ongoing recombination with other lineages at this locus. These patterns of deep haplotype divergence and long-range linkage disequilibrium are best explained by a prolonged period of ancestral population subdivision followed by relatively recent interbreeding. This inference supports human evolution models that incorporate admixture between divergent African branches of the genus Homo.
journal_name
Geneticsjournal_title
Geneticsauthors
Garrigan D,Mobasher Z,Kingan SB,Wilder JA,Hammer MFdoi
10.1534/genetics.105.041095keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
1849-56issue
4eissn
0016-6731issn
1943-2631pii
genetics.105.041095journal_volume
170pub_type
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