Abstract：
:We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the first analytical closed-form approximation for arbitrary migration rate to appear in the literature. We find that the establishment probability lies between the weak and the strong migration limits if we condition the origin of the mutation to the deme where it is advantageous. This is not the case when we condition the mutation to first occur in a deme where it is disadvantageous. In this case we find that an intermediate migration rate maximizes the probability of establishment. We extend our results to the cases of multiple demes, two demes with asymmetric rates of gene flow, and asymmetric carrying capacities. The latter case allows us to illustrate how density regulation can affect establishment probabilities. Finally, we use our results to investigate the role of gene flow on the rate of local adaptation and identify cases in which intermediate amounts of gene flow facilitate the rate of local adaptation as compared to two populations without gene flow.
journal_name
Geneticsjournal_title
Geneticsauthors
Tomasini M,Peischl Sdoi
10.1534/genetics.118.301104subject
Has Abstractpub_date
2018-07-01 00:00:00pages
885-895issue
3eissn
0016-6731issn
1943-2631pii
genetics.118.301104journal_volume
209pub_type
杂志文章相关文献
GENETICS文献大全abstract：:The breeding systems of many organisms are cryptic and difficult to investigate with observational data, yet they have profound effects on a species' ecology, evolution, and genome organization. Genomic approaches offer a novel, indirect way to investigate breeding systems, specifically by studying the transmission of...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.179879
更新日期：2015-11-01 00:00:00
abstract：:We have selected 210 mutants able to grow on sucrose in the presence of 2-deoxyglucose. We identified recessive mutations in three major complementation groups that cause constitutive (glucose-insensitive) secreted invertase synthesis. Two groups comprise alleles of the previously identified HXK2 and REG1 genes, and t...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：:Explanations of the evolution of diploidy have focused on the advantages gained from masking deleterious alleles. Recent theory has shown, however, that masking does not always provide an advantage to diploidy and would never favor diploidy in predominantly asexual organisms. We explore a neglected alternative theory ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:The effect of nonhomologous DNA sequences at one or both sides of short genetic intervals on recombination within that interval was investigated, using an interplasmidic recombination system in Escherichia coli K-12. The recombining plasmids were derivatives of pBR322 and pACYC184, which share a 1330-nucleotide sequen...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C element causes the crippled growth (CG) cell degeneration. CG results from the inappropriate autocatalytic activation of the PaMpk1 MAPK pathway durin...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.139469
更新日期：2012-06-01 00:00:00
abstract：:The Triplo-lethal locus (Tpl) is unique in its dosage sensitivity; no other locus in Drosophila has been identified that is lethal when present in three doses. Tpl is also haplo-lethal, and its function is still a mystery. Previous workers have found it nearly impossible to mutationally inactive Tpl other than by comp...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:The experimental population genetics of Y-chromosome drive in Drosophila melanogaster is approximated by studying the behavior of T(Y;2),SD lines. These exhibit "pseudo-Y" drive through the effective coupling of the Y chromosome to the second chromosome meiotic drive locus, Segregation distorter (SD). T(Y;2),SD males ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:An analysis of mortality is undertaken in two breeds of pigs: Danish Landrace and Yorkshire. Zero-inflated and standard versions of hierarchical Poisson, binomial, and negative binomial Bayesian models were fitted using Markov chain Monte Carlo (MCMC). The objectives of the study were to investigate whether there is s...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.110759
更新日期：2010-01-01 00:00:00
abstract：:Bisphenol A (BPA) is an organic compound to which human populations are ubiquitously exposed. Epidemiological data suggest BPA exposure might be associated with higher rates of diabetes and reproductive anomalies. Health concerns also include transgenerational consequences, but these mechanisms are crudely defined. Si...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.163170
更新日期：2014-05-01 00:00:00
abstract：:Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated into neurons. Sodium ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303399
更新日期：2020-08-01 00:00:00
abstract：:The transmission of transposed Ac elements in progeny derived by self-pollination of ten transformed tomato plants has been examined by Southern hybridization analysis. We show that six of these primary transformants have transmitted a transposed Ac to at least one progeny. One of the families was segregating for at l...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Cell-cell fusion is essential for a variety of developmental steps in many eukaryotic organisms, during both fertilization and vegetative cell growth. Although the molecular mechanisms associated with intracellular membrane fusion are well characterized, the molecular mechanisms of plasma membrane merger between cells...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.096149
更新日期：2009-02-01 00:00:00
abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.119.300240
更新日期：2020-02-01 00:00:00
abstract：:Two strains of Drosophila melanogaster derived from different geographical localities were subjected to selection for fast and slow developmental rate. Four enzyme polymorphisms were monitored for their response to such selection. Significant changes in allele frequencies were effected for the alphaGpdh and 6Pgd polym...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-09-01 00:00:00
abstract：:According to theory, F(2) hybrid breakdown (lethality or sterility) is due to incompatibilities between interacting genes of the different species (i.e., the breaking up of coadapted gene complexes). Detection of such incompatibilities is particularly straightforward in haplodiploid species, because virgin F(1) hybrid...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.117.300167
更新日期：2018-06-01 00:00:00
abstract：:For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.071696
更新日期：2007-06-01 00:00:00
abstract：:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 tra...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.090134
更新日期：2008-10-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.111.138214
更新日期：2012-03-01 00:00:00
abstract：:To gain new mechanistic insight into ER homeostasis and the biogenesis of secretory proteins, we screened a genomewide collection of yeast mutants for defective intracellular retention of the ER chaperone, Kar2p. We identified 87 Kar2p-secreting strains, including a number of known components in secretory protein modi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.101105
更新日期：2009-07-01 00:00:00
abstract：:The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume composition...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:The idea of trait-based linkage analysis in half-sibs is extended by comparing the frequency of parental marker haplotypes in animals with different phenotypes. This article first presents the likelihood of observing different classes of paternal haplotypes in a half-sib family, where only family members of a certain ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1973-08-01 00:00:00
abstract：:There is an increasing awareness that selection affecting linked neutral sites strongly influences on how diversity is distributed across the genome. In particular, linked selection is likely involved in the formation of heterogenous landscapes of genetic diversity, including genomic regions with locally reduced effec...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.301991
更新日期：2019-05-01 00:00:00
abstract：:The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.048793
更新日期：2006-01-01 00:00:00
abstract：:The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast Saccharomyces cerevisiae, mutations in the RecQ homolog, SGS1, phenoc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.157370
更新日期：2013-12-01 00:00:00
abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300139
更新日期：2017-10-01 00:00:00
abstract：:The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologic...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters containing 4607 genes, over one-fifth of all genes in C. elegans. Cluster genes are distributed unevenly in the genome, with t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.040030
更新日期：2006-01-01 00:00:00
abstract：:Gene targeting using sequence insertion vectors generally results in integration of one copy of the targeting vector generating a tandem duplication of the cognate chromosomal region of homology. However, occasionally the target locus is found to contain >1 copy of the integrated vector. The mechanism by which the lat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
