Abstract：
:The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the postembryonic stages, the same set of signaling pathways controls highly plastic regulation of size increase and pattern elaboration during larval stages, and cell proliferation and reprograming during metamorphosis. Tracheal tube morphogenesis is also regulated by physicochemical interaction of the cell and apical extracellular matrix to regulate optimal geometry suitable for air flow. The trachea system senses both the external oxygen level and the metabolic activity of internal organs, and helps organismal adaptation to changes in environmental oxygen level. Cellular and molecular mechanisms underlying the high plasticity of tracheal development and physiology uncovered through research on Drosophila are discussed.
journal_name
Geneticsjournal_title
Geneticsauthors
Hayashi S,Kondo Tdoi
10.1534/genetics.117.300167subject
Has Abstractpub_date
2018-06-01 00:00:00pages
367-380issue
2eissn
0016-6731issn
1943-2631pii
genetics.117.300167journal_volume
209pub_type
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