Abstract:
:Genic variation in natural populations of Drosophila simulans was surveyed using allozymic and two-dimensional electrophoretic techniques. Consistent with some previous reports, allozymic heterozygosity appeared lower than in the sibling species D. melanogaster (0.07 vs. 0.16). No variation was detected by two-dimensional electrophoresis of 19 lines scored for 70 abundant proteins. This is consistent with reported reductions in estimates of genic heterozygosity by two-dimensional electrophoresis in D. melanogaster, Mus musculus, and man. Although the amount of intraspecific variation detected in abundant proteins was lower than that detected for allozymes in D. simulans and D. melanogaster, the genetic distances between the sibling species calculated from the two data sets are not significantly different (0.35 and 0.20). The allozyme and two-dimensional electrophoresis data confirmed the impression from other measures of genetic variation (mitochondrial DNA restriction maps and inversion polymorphisms) that D. simulans is substantially less variable than D. melanogaster.
journal_name
Geneticsjournal_title
Geneticsauthors
Ohnishi S,Leigh Brown AJ,Voelker RA,Langley CHsubject
Has Abstractpub_date
1982-01-01 00:00:00pages
127-36issue
1eissn
0016-6731issn
1943-2631journal_volume
100pub_type
杂志文章相关文献
GENETICS文献大全abstract::We present methods for estimating the parameters of inheritance and selection that appear in a quantitative genetic model for the evolution growth trajectories and other "infinite-dimensional" traits that we recently introduced. Two methods for estimating the additive genetic covariance function are developed, a "full...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::In eucaryotes a cell cycle control called a checkpoint ensures that mitosis occurs only after chromosomes are completely replicated and any damage is repaired. The function of this checkpoint in budding yeast requires the RAD9 gene. Here we examine the role of the RAD9 gene in the arrest of the 12 cell division cycle ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Brassica self-incompatibility (SI) is controlled by SLG and SRK expressed in the stigma and by SP11/SCR expressed in the anther. We determined the sequences of the S domains of 36 SRK alleles, 13 SLG alleles, and 14 SP11 alleles from Brassica oleracea and B. rapa. We found three S haplotypes lacking SLG genes in B. ra...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::We have characterized tandem duplications in the rII regions of phage T4. The rII deletion r1589 blocks only the function of the rIIA cistron, although it extends into the B cistron. Another rII deletion, r1236, blocks the function of the rIIB cistron and overlaps r1589. When a cross is made between r1589 and r1236, t...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::The relationship between multidimensional form of the adult mouse mandible and body size is examined from an ontogenetic perspective. The origin and ontogeny of phenotypic correlations are described in terms of genetic and environmental covariance patterns between adult skeletal morphology and growth in body weight. D...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract::Levels of genetic variation and linkage disequilibrium (LD) are critical factors in association mapping methods as well as in identification of loci that have been targets of selection. Maize, an outcrosser, has a high level of sequence variation and a limited extent of LD. Sorghum, a closely related but largely self-...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.167.1.471
更新日期:2004-05-01 00:00:00
abstract::The effect of genetic hitchhiking on neutral variation is analyzed in subdivided populations with differentiated demes. After fixation of a favorable mutation, the consequences on particular subpopulations can be radically different. In the subpopulation where the mutation first appeared by mutation, variation at link...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.032813
更新日期:2005-01-01 00:00:00
abstract::This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract::The availability of genomewide dense markers brings opportunities and challenges to breeding programs. An important question concerns the ways in which dense markers and pedigrees, together with phenotypic records, should be used to arrive at predictions of genetic values for complex traits. If a large number of marke...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101501
更新日期:2009-05-01 00:00:00
abstract::Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.188581
更新日期:2016-07-01 00:00:00
abstract::Identifying loci under natural selection from genomic surveys is of great interest in different research areas. Commonly used methods to separate neutral effects from adaptive effects are based on locus-specific population differentiation coefficients to identify outliers. Here we extend such an approach to estimate d...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.092221
更新日期:2008-10-01 00:00:00
abstract::How many genes contribute to reproductive isolation between closely related species? We determined the number of genes located in the 9D-12B region of the Drosophila mauritiana X chromosome that cause hybrid male sterility in a D. simulans background. Previous low resolution studies suggested that a single hybrid ster...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::This paper studies the properties of a new class of demographic parameters for age-structured populations and analyzes the effect of natural selection on these parameters. Two new demographic variables are introduced: the entropy of a population and the reproductive potential. The entropy of a population measures the ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::Reciprocal recurrent selection (RRS), which assumes overdominant loci to be important, alters two genetically different populations to improve their crossbred mean. Individual plants from two populations (A and B) are selfed and also crossed with plants from the reciprocal female tester population (B and A, respective...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::We examined the prevalence of interactions between pairs of short chromosomal regions from one species (Solanum habrochaites) co-introgressed into a heterospecific genetic background (Solanum lycopersicum). Of 105 double introgression line (DIL) families generated from a complete diallele combination of 15 chromosomal...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.095679
更新日期:2009-01-01 00:00:00
abstract::The recent progress in sequencing technologies makes possible large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The results of such efforts depend heavily on the use of efficient study designs and analytical methods. We introduce here a unified framework for associat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.131813
更新日期:2011-11-01 00:00:00
abstract::C4 and CYP21 are two adjacent, but functionally unrelated genes residing in the middle of the mammalian major histocompatibility complex (Mhc). The C4 gene codes for the fourth component of the complement cascade, whereas the CYP21 gene specifies an enzyme (cytochrome P450c21) of the glucocorticoid and mineralocortico...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::In most eukaryotes, crossovers are not independently distributed along the length of a chromosome. Instead, they appear to avoid close proximity to one another--a phenomenon known as crossover interference. Previously, for three of the five Arabidopsis chromosomes, we measured the strength of interference and suggeste...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.040055
更新日期:2005-06-01 00:00:00
abstract::Interchromosomal duplications are especially important for the study of X-linked genes. Males inheriting a mutation in a vital X-linked gene cannot survive unless there is a wild-type copy of the gene duplicated elsewhere in the genome. Rescuing the lethality of an X-linked mutation with a duplication allows the mutat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.123265
更新日期:2010-12-01 00:00:00
abstract::Genes at the SerH locus of the ciliated protist Tetrahymena thermophila specify the major (H) surface protein on cells grown at 20-36 degrees. Alternative proteins L, T, S and I are expressed under different conditions of temperature and culture media. Mutants unable to express SerH genes were examined for expression ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Fifteen classical linkage groups were identified in two salmonid species (Salmo trutta and Salmo gairdneri) and three fertile, interspecific hybrids (S. gairdneri X Salmo clarki, Salvelinus fontinalis X Salvelinus namaycush and S. fontinalis X Salvelinus alpinus) by backcrossing multiply heterozygous individuals. Thes...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract::As an ancient segmental tetraploid, the maize (Zea mays L.) genome contains large numbers of paralogs that are expected to have diverged by a minimum of 10% over time. Nearly identical paralogs (NIPs) are defined as paralogous genes that exhibit > or = 98% identity. Sequence analyses of the "gene space" of the maize i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.064006
更新日期:2007-01-01 00:00:00
abstract::Catfish is the major aquaculture species in the United States. The hybrid catfish produced by crossing channel catfish females with blue catfish males exhibit a number of desirable production traits, but their mass production has been difficult. To introduce desirable genes from blue catfish into channel catfish throu...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::Previously we have shown that the nucleolus organizer region (NOR) of Neurospora crassa changes size frequently during the premeiotic portion of the sexual phase. Here, we have investigated whether these changes in size originate only in specific regions of the NOR, or are distributed throughout the NOR. In two specia...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::A scheme for rapidly mapping chromosome rearrangements relative to the physical map of Caenorhabditis elegans is described that is based on hybridization patterns of cloned DNA on meiotic nuclei, as visualized by fluorescent in situ hybridization. From the nearly complete physical map, DNA clones, in yeast artificial ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.082206
更新日期:2007-12-01 00:00:00
abstract::The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-08-01 00:00:00
abstract::This paper describes a perturbation experiment on the frequency of the F and S Alcohol dehydrogenase (Adh) alleles of D. melanogaster. Fifty-four iso-female lines set up from three wild populations and with initial F frequencies of either 0.25, 0.50 or 0.75 were maintained on standard laboratory food medium at 22 degr...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Most species of the Drosophila genus and other Diptera are polymorphic for paracentric inversions. A common observation is that successful inversions are of intermediate size. We test here the hypothesis that the selected property is the recombination length of inversions, not their physical length. If so, physical le...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00