Fold recognition of the human immunodeficiency virus type 1 V3 loop and flexibility of its crown structure during the course of adaptation to a host.

abstract：:Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p. These four proteins all participate in or influence a well-studied agglutinin interaction mediated by Aga1p-Aga2p complexes and Sag1p; however, they also play redundant and essent...

journal_title：Genetics

authors： Huang G,Dougherty SD,Erdman SE

更新日期：2009-05-01 00:00:00

abstract：:A natural population of Culex tritaeniorhynchus was sampled to test the efficacy of a proposed method to detect and measure concealed variability. Thirty-nine lethals and ten recessive visible mutations were uncovered out of a total of 125 chromosomes tested. ...

journal_title：Genetics

authors： Sakai RK,Baker RH

更新日期：1972-06-01 00:00:00

abstract：:NudC encodes a protein of unknown biochemical function that is required for nuclear migration. In an attempt to define its function by identifying interacting proteins, a screen for extragenic suppressors of the temperature-sensitive nudC3 mutation was undertaken that identified nine snc genes. Here we demonstrate tha...

journal_title：Genetics

authors： Chiu YH,Morris NR

更新日期：1997-03-01 00:00:00

abstract：:Low-coverage next-generation sequencing methodologies are routinely employed to genotype large populations. Missing data in these populations manifest both as missing markers and markers with incomplete allele recovery. False homozygous calls at heterozygous sites resulting from incomplete allele recovery confound man...

journal_title：Genetics

authors： Fragoso CA,Heffelfinger C,Zhao H,Dellaporta SL

更新日期：2016-02-01 00:00:00

abstract：:About 450 black rats (Rattus rattus) were collected from 25 localities in Asia and Oceania. Their serum transferrins were analyzed by a newly developed thin layer acrylamide gel electrophoresis accompanied with acrinol pretreatment, exhibiting 12 transferrin bands. Generally, Asian type rats (2N=42) had fast-moving tr...

journal_title：Genetics

authors： Moriwaki K,Kato H,ImalH,Tsuchiya K,Yosida T

更新日期：1975-02-01 00:00:00

abstract：:Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...

journal_title：Genetics

authors： Richman AD,Herrera LG,Nash D

更新日期：2003-05-01 00:00:00

abstract：:We formalize the use of allele frequency and geographic information for the construction of gene trees at the intraspecific level and extend the concept of evolutionary parsimony to molecular variance parsimony. The central principle is to consider a particular gene tree as a variable to be optimized in the estimation...

journal_title：Genetics

authors： Excoffier L,Smouse PE

更新日期：1994-01-01 00:00:00

abstract：:Drosophila dishevelled (dsh) functions in two pathways: it is necessary to transduce Wingless (Wg) signaling and it is required in planar cell polarity. To learn more about how Dsh can discriminate between these functions, we performed genetic screens to isolate additional dsh alleles and we examined the potential rol...

journal_title：Genetics

authors： Penton A,Wodarz A,Nusse R

更新日期：2002-06-01 00:00:00

abstract：:The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

journal_title：Genetics

authors： Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

更新日期：2010-07-01 00:00:00

abstract：:Birds are characterized by female heterogamety; females carry the Z and W sex chromosomes, while males have two copies of the Z chromosome. We suggest here that full differentiation of the Z and W sex chromosomes of birds did not take place until after the split of major contemporary lineages, in the late Cretaceous. ...

journal_title：Genetics

authors： Ellegren H,Carmichael A

更新日期：2001-05-01 00:00:00

abstract：:We show how to incorporate fluctuations of the recombination rate along the chromosome into standard gene-genealogical models for the decorrelation of gene histories. This enables us to determine how small-scale fluctuations (Poissonian hot-spot model) and large-scale variations (Kong et al. 2002) of the recombination...

journal_title：Genetics

authors： Eriksson A,Mehlig B

更新日期：2005-02-01 00:00:00

abstract：:Conditional cdc1(Ts) mutants of S. cerevisiae arrest with a phenotype similar to that exhibited by Mn(2+)-depleted cells. Sequence similarity between Cdc1p and a class of Mn(2+)-dependent phosphoesterases, as well as the observation that conditional cdc1(Ts) growth can be ameliorated by Mn(2+) supplement, suggests tha...

journal_title：Genetics

authors： Eguez L,Chung YS,Kuchibhatla A,Paidhungat M,Garrett S

更新日期：2004-05-01 00:00:00

abstract：:Site-specific recombinases are widely used tools for analysis of genetics, development, and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because the FRT and lox target sites for the commonly used FLP and Cre recombinases are asymmetrical, and mus...

journal_title：Genetics

authors： Titen SWA,Johnson MTB,Capecchi M,Golic KG

更新日期：2020-08-01 00:00:00

abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...

journal_title：Genetics

authors： Keightley PD

更新日期：1994-12-01 00:00:00

abstract：:Bacteriophage T4 cytosine-containing DNA is cleaved at a single site by the restriction endonuclease, Bam H1. The site lies within the late region of the T4 genome, close to, or within, gene 8, one of the structural genes of the phage particle baseplate. ...

journal_title：Genetics

authors： Wilson GG,Neve RL,Edlin GJ,Konigsberg WH

更新日期：1979-10-01 00:00:00

abstract：:A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was r...

journal_title：Genetics

authors： Shiina T,Ota M,Shimizu S,Katsuyama Y,Hashimoto N,Takasu M,Anzai T,Kulski JK,Kikkawa E,Naruse T,Kimura N,Yanagiya K,Watanabe A,Hosomichi K,Kohara S,Iwamoto C,Umehara Y,Meyer A,Wanner V,Sano K,Macquin C,Ikeo K,T

更新日期：2006-07-01 00:00:00

abstract：:Sex differences occur in most species and affect a variety of biological traits including morphology, behavior, and life history. The nematode Caenorhabditis elegans exists as a population of self-fertile hermaphrodites with occasional males, which differ anatomically and behaviorally from hermaphrodites. Here we show...

journal_title：Genetics

authors： van den Berg MC,Woerlee JZ,Ma H,May RC

更新日期：2006-06-01 00:00:00

abstract：:The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by monitoring their relative abundance across time points in a si...

journal_title：Genetics

authors： Matuszewski S,Hildebrandt ME,Ghenu AH,Jensen JD,Bank C

更新日期：2016-09-01 00:00:00

abstract：:Ribosome biogenesis requires at least 18 putative ATP-dependent RNA helicases in Saccharomyces cerevisiae. To explore the functional environment of one of these putative RNA helicases, Dbp6p, we have performed a synthetic lethal screen with dbp6 alleles. We have previously characterized the nonessential Rsa1p, whose n...

journal_title：Genetics

authors： de la Cruz J,Lacombe T,Deloche O,Linder P,Kressler D

更新日期：2004-04-01 00:00:00

abstract：:We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling thos...

journal_title：Genetics

authors： Roux F,Colomé-Tatché M,Edelist C,Wardenaar R,Guerche P,Hospital F,Colot V,Jansen RC,Johannes F

更新日期：2011-08-01 00:00:00

abstract：:There are many types of DNA damage that are repaired by a multiplicity of different repair pathways. All damage and repair occur in the context of chromatin, and histone modifications are involved in many repair processes. We have analyzed the roles of H2A and its modifications in repair by mutagenizing modifiable res...

journal_title：Genetics

authors： Moore JD,Yazgan O,Ataian Y,Krebs JE

更新日期：2007-05-01 00:00:00

abstract：:Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-s...

journal_title：Genetics

authors： Phillips PC,Johnson NA

更新日期：1998-09-01 00:00:00

abstract：:Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus). This suggests that these genes may contribute to control...

journal_title：Genetics

authors： Pryce JE,Hayes BJ,Bolormaa S,Goddard ME

更新日期：2011-03-01 00:00:00

abstract：:In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets...

journal_title：Genetics

authors： Watters MK,Randall TA,Margolin BS,Selker EU,Stadler DR

更新日期：1999-10-01 00:00:00

abstract：:We have analyzed pregastrulation cleavage patterns in Caenorhabditis elegans embryos homozygous for various chromosomal deficiencies. By two different estimates these deficiencies represent between 37 and 49% of the genome, including the entire X chromosome and substantial portions of each of the five autosomes. Among...

journal_title：Genetics

authors： Storfer-Glazer FA,Wood WB

更新日期：1994-06-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:The relationship between multidimensional form of the adult mouse mandible and body size is examined from an ontogenetic perspective. The origin and ontogeny of phenotypic correlations are described in terms of genetic and environmental covariance patterns between adult skeletal morphology and growth in body weight. D...

journal_title：Genetics

authors： Atchley WR,Plummer AA,Riska B

更新日期：1985-11-01 00:00:00

abstract：:Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1)...

journal_title：Genetics

authors： Jia Z,Xu S

更新日期：2007-05-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:The Duchenne muscular dystrophy (Dmd) locus lies in a region of the X chromosome that experiences a high rate of recombination and is thus expected to be relatively unaffected by the effects of selection on nearby genes. To provide a picture of nucleotide variability at a high-recombination locus in humans, we sequenc...

journal_title：Genetics

authors： Nachman MW,Crowell SL

更新日期：2000-08-01 00:00:00