Abstract:
:We show how to incorporate fluctuations of the recombination rate along the chromosome into standard gene-genealogical models for the decorrelation of gene histories. This enables us to determine how small-scale fluctuations (Poissonian hot-spot model) and large-scale variations (Kong et al. 2002) of the recombination rate influence this decorrelation. We find that the empirically determined large-scale variations of the recombination rate give rise to a significantly slower decay of correlations compared to the standard, unstructured gene-genealogical model assuming constant recombination rate. A model with long-range recombination-rate variations and with demographic structure (divergent population) is found to be consistent with the empirically observed slow decorrelation of gene histories. Conversely, we show that small-scale recombination-rate fluctuations do not alter the large-scale decorrelation of gene histories.
journal_name
Geneticsjournal_title
Geneticsauthors
Eriksson A,Mehlig Bdoi
10.1534/genetics.103.018002keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
1175-8issue
2eissn
0016-6731issn
1943-2631pii
genetics.103.018002journal_volume
169pub_type
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