Polymorphic regions affecting human height also control stature in cattle.

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:The L-shaped distribution of estimated QTL effects (R(2)) has long been reported. We recently showed that a metabolic mechanism could account for this phenomenon. But other nonexclusive genetic or nongenetic causes may contribute to generate such a distribution. Using analysis and simulations of an additive genetic mo...

journal_title：Genetics

authors： Bost B,de Vienne D,Hospital F,Moreau L,Dillmann C

更新日期：2001-04-01 00:00:00

abstract：:We have isolated 15 spontaneous mutants resistant to one or several antibiotics like chloramphenicol, erythromycin and spiramycin. We have shown by several criteria that all of them result from mutations localized in the mitochondrial DNA. The mutations have been mapped by allelism tests and by two- and three-factor c...

journal_title：Genetics

authors： Netter P,Petrochilo E,Slonimski PP,Bolotin-Fukuhara M,Coen D,Deutsch J,Dujon B

更新日期：1974-12-01 00:00:00

abstract：:The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased e...

journal_title：Genetics

authors： Hustad CM,Perry WL,Siracusa LD,Rasberry C,Cobb L,Cattanach BM,Kovatch R,Copeland NG,Jenkins NA

更新日期：1995-05-01 00:00:00

abstract：:Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP kinase (MAPK) pathways are essential for communicat...

journal_title：Genetics

authors： Fischer MS,Wu VW,Lee JE,O'Malley RC,Glass NL

更新日期：2018-06-01 00:00:00

abstract：:The Saccharomyces cerevisiae PHO85 gene encodes a nonessential cyclin-dependent kinase that associates with 10 cyclin subunits. To survey the functions provided by Pho85, we identified mutants that require PHO85 for viability. We identified mutations that define seven Pho Eighty-Five Requiring or Efr loci, six of whic...

journal_title：Genetics

authors： Lenburg ME,O'Shea EK

更新日期：2001-01-01 00:00:00

abstract：:The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...

journal_title：Genetics

authors： Lessard S

更新日期：2005-09-01 00:00:00

abstract：:To understand the role of Los1p in pre-tRNA splicing, we sought los1 multicopy suppressors. We found SOL1 that suppresses both point and null LOS1 mutations. Since, when fused to the Ga14p DNA-binding domain, Los1p activates transcription, we tested whether Los1p regulates SOL1. We found that las1 mutants have deplete...

journal_title：Genetics

authors： Shen WC,Stanford DR,Hopper AK

更新日期：1996-06-01 00:00:00

abstract：:Genetic divergence in the form of the mandible is examined in ten inbred strains of mice. Several univariate and multivariate genetic distance estimates are given for the morphological data and these estimates are compared to measures of genealogical and molecular divergence. Highly significant divergence occurs among...

journal_title：Genetics

authors： Atchley WR,Newman S,Cowley DE

更新日期：1988-09-01 00:00:00

abstract：:An inbreeding matrix is defined for populations with overlapping generations. In the short term it can be expressed in terms of a matrix specifying the passage of genes between the different age groups (and sexes) and a diagonal matrix whose elements depend on the number of individuals in each age group. Formulae for ...

journal_title：Genetics

authors： Johnson DL

更新日期：1977-11-01 00:00:00

abstract：:Adaptive dynamics formalism demonstrates that, in a constant environment, a continuous trait may first converge to a singular point followed by spontaneous transition from a unimodal trait distribution into a bimodal one, which is called "evolutionary branching." Most previous analyses of evolutionary branching have b...

journal_title：Genetics

authors： Wakano JY,Iwasa Y

更新日期：2013-01-01 00:00:00

abstract：:Hepatic glucocorticoid receptor binding activity was measured in A/J, C57BL/6J, their F1 reciprocal crosses and their F1 recombinant inbred (RI) lines. The glucocorticoid binding capacity was measured in Hepes buffer and Hepes buffer plus dithiothreitol (DTT). The A/J parental strain showed higher levels, and a greate...

journal_title：Genetics

authors： Liu SL,Erickson RP

更新日期：1986-07-01 00:00:00

abstract：:The effect of full-sib inbreeding on competitive male-mating ability (CImale symbol) in Drosophila melanogaster was investigated in two experiments. In the first, five inbred lines (with reserves) were assessed up to 18 generations. Linear inbreeding depression, of 5.9% per 10% increase in homozygosity, was observed. ...

journal_title：Genetics

authors： Sharp PM

更新日期：1984-04-01 00:00:00

abstract：:Mitochondrial DNAs (mtDNAs) from 167 American Indians including 87 Amerind-speakers (Amerinds) and 80 Nadene-speakers (Nadene) were surveyed for sequence variation by detailed restriction analysis. All Native American mtDNAs clustered into one of four distinct lineages, defined by the restriction site variants: HincII...

journal_title：Genetics

authors： Torroni A,Schurr TG,Yang CC,Szathmary EJ,Williams RC,Schanfield MS,Troup GA,Knowler WC,Lawrence DN,Weiss KM

更新日期：1992-01-01 00:00:00

abstract：:The swi8+ gene of Schizosaccharomyces pombe appears to be involved in the termination step of copy synthesis during mating-type (MT) switching. Mutations in swi8 confer a general mutator phenotype and, in particular, generate specific mutations in the MT region. Sequencing of the MT cassettes of the h90 swi8-137 mutan...

journal_title：Genetics

authors： Fleck O,Rudolph C,Albrecht A,Lorentz A,Schär P,Schmidt H

更新日期：1994-11-01 00:00:00

abstract：:The mammalian GADD45 (growth arrest and DNA-damage inducible) gene family is composed of three highly homologous small, acidic, nuclear proteins: GADD45alpha, GADD45beta, and GADD45gamma. GADD45 proteins are involved in important processes such as regulation of DNA repair, cell cycle control, and apoptosis. Annotation...

journal_title：Genetics

authors： Peretz G,Bakhrat A,Abdu U

更新日期：2007-11-01 00:00:00

abstract：:Serrate (Ser) is an essential gene in Drosophila melanogaster best known for the Ser dominant (SerD) allele and its effects on wing development. Animals heterozygous or homozygous for SerD are viable and exhibit loss of wing margin tissue and associated bristles and hairs. The Beaded of Goldschmidt (BdG) allele of Ser...

journal_title：Genetics

authors： Hukriede NA,Fleming RJ

更新日期：1997-02-01 00:00:00

abstract：:The heterochromatin of the third chromosome is the largest uncharacterized region of the Drosophila melanogaster genome, and the last major block of D. melanogaster heterochromatin to be thoroughly analyzed. In the present study, this region was genetically dissected by generating and analyzing a series of attached, d...

journal_title：Genetics

authors： Marchant GE,Holm DG

更新日期：1988-10-01 00:00:00

abstract：:The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection exper...

journal_title：Genetics

authors： Hillis DA,Yadgary L,Weinstock GM,Pardo-Manuel de Villena F,Pomp D,Fowler AS,Xu S,Chan F,Garland T Jr

更新日期：2020-11-01 00:00:00

abstract：:Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-s...

journal_title：Genetics

authors： Phillips PC,Johnson NA

更新日期：1998-09-01 00:00:00

abstract：:We have identified two Saccharomyces cerevisiae genes that, in high copy, confer resistance to Kluyveromyces lactis zymocin, an inhibitor that blocks cells in the G(1) phase of the cell cycle prior to budding and DNA replication. One gene (GRX3) encodes a glutaredoxin and is likely to act at the level of zymocin entry...

journal_title：Genetics

authors： Jablonowski D,Butler AR,Fichtner L,Gardiner D,Schaffrath R,Stark MJ

更新日期：2001-12-01 00:00:00

abstract：:During development, the Notch receptor regulates many cell fate decisions by a signaling pathway that has been conserved during evolution. One positive regulator of Notch is Deltex, a cytoplasmic, zinc finger domain protein, which binds to the intracellular domain of Notch. Phenotypes resulting from mutations in delte...

journal_title：Genetics

authors： Cornell M,Evans DA,Mann R,Fostier M,Flasza M,Monthatong M,Artavanis-Tsakonas S,Baron M

更新日期：1999-06-01 00:00:00

abstract：:We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication. The family includes S. cerevisiae proteins Rad2p and its human homolog XPGC, Rad27p and its mammalian homolog FEN-1, and Exonuclea...

journal_title：Genetics

authors： Fikus MU,Mieczkowski PA,Koprowski P,Rytka J,Sledziewska-Gójska E,Ciésla Z

更新日期：2000-01-01 00:00:00

abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...

journal_title：Genetics

authors： Spiliopoulou A,Colombo M,Orchard P,Agakov F,McKeigue P

更新日期：2017-05-01 00:00:00

abstract：:In(2LR)PL is a large pericentric inversion polymorphic in populations of Drosophila melanogaster on two Indian Ocean islands. This polymorphism is puzzling: because crossing over in female heterokaryotypes produces inviable zygotes, such inversions are thought to be underdominant and should be quickly eliminated from ...

journal_title：Genetics

authors： Coyne JA,Aulard S,Berry A

更新日期：1991-11-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) that have only one end with homology to a donor duplex undergo repair by strand invasion followed by replication to the chromosome terminus (break-induced replication, BIR). Using a transformation-based assay system, it was previously shown that BIR could occur by several rounds...

journal_title：Genetics

authors： Stafa A,Donnianni RA,Timashev LA,Lam AF,Symington LS

更新日期：2014-04-01 00:00:00

abstract：:The idealized individual in many fungal species is a haploid self-sterile hermaphrodite that may be propagated by asexually produced spores or that may reproduce sexually. In field populations, polymorphism occurs for female-sterile/hermaphrodite status, and female-sterile mutants, which function only as males during ...

journal_title：Genetics

authors： Leslie JF,Klein KK

更新日期：1996-10-01 00:00:00

abstract：:The Drosophila hook gene encodes a novel component of the endocytic compartment. Previously identified hook alleles, which still expressed truncated Hook proteins, affected the accumulation of internalized transmembrane ligands into multivesicular bodies (MVBs). To determine the hook null phenotype, we isolated nine n...

journal_title：Genetics

authors： Krämer H,Phistry M

更新日期：1999-02-01 00:00:00

abstract：:The gastrulation defective (gd) locus encodes a novel serine protease that is involved in specifying the dorsal-ventral axis during embryonic development. Mutant alleles of gd have been classified into three complementation groups, two of which exhibit strong interallelic (intragenic) complementation. To understand th...

journal_title：Genetics

authors： Ponomareff G,Giordano H,DeLotto Y,DeLotto R

更新日期：2001-10-01 00:00:00

abstract：:Most studies of mutation rates implicitly assume that they remain constant throughout development of the germline. However, researchers recently used a novel statistical framework to reveal that mutation rates differ dramatically during sperm development in Drosophila melanogaster. Here a general framework is describe...

journal_title：Genetics

authors： Fu YX

更新日期：2013-08-01 00:00:00