Genetic divergence in mandible form in relation to molecular divergence in inbred mouse strains.

abstract：:Five bivariate distributions of wing dimensions of Drosophila melanogaster were measured, in flies 1) subjected to four defined environmental regimes during development, 2) taken directly from nature in seven U.S. states, 3) selected in ten populations for change in wing form, and 4) sampled from 21 long inbred wild-t...

journal_title：Genetics

authors： Weber KE

更新日期：1990-12-01 00:00:00

abstract：:Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel ...

journal_title：Genetics

authors： Spracklin G,Fields B,Wan G,Becker D,Wallig A,Shukla A,Kennedy S

更新日期：2017-07-01 00:00:00

abstract：:As one of the world's most important food crops, the potato (Solanum tuberosum L.) has spurred innovation in autotetraploid genetics, including in the use of SNP arrays to determine allele dosage at thousands of markers. By combining genotype and pedigree information with phenotype data for economically important trai...

journal_title：Genetics

authors： Endelman JB,Carley CAS,Bethke PC,Coombs JJ,Clough ME,da Silva WL,De Jong WS,Douches DS,Frederick CM,Haynes KG,Holm DG,Miller JC,Muñoz PR,Navarro FM,Novy RG,Palta JP,Porter GA,Rak KT,Sathuvalli VR,Thompson AL,Yench

更新日期：2018-05-01 00:00:00

abstract：:The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profi...

journal_title：Genetics

authors： Gong WJ,Golic KG

更新日期：2006-01-01 00:00:00

abstract：:Two replications of a complete diallel cross experiment were performed among four partially inbred lines of mice. These inbred lines originated from a random-bred ICR strain and were produced by 12 generations of full sibbing (F congruent to 92%). Individual body weight was recorded for each animal at 12, 21, 42 and 5...

journal_title：Genetics

authors： Jamison MG,White JM,Vinson WE,Hinkelmann K

更新日期：1975-10-01 00:00:00

abstract：:Restorer-of-fertility (Rf) alleles for S-type cytoplasmic male sterility (CMS-S) are prevalent in Mexican races of maize and teosinte. Forty-five Rf alleles from 26 races of maize and 6 Rf alleles from different accessions of teosinte were found to be homozygous viable, consistent with the hypothesis that they are nat...

journal_title：Genetics

authors： Gabay-Laughnan S,Chase CD,Ortega VM,Zhao L

更新日期：2004-02-01 00:00:00

abstract：:Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's...

journal_title：Genetics

authors： Dayarian A,Shraiman BI

更新日期：2014-07-01 00:00:00

abstract：:A total of 358 lys2 mutants of Saccharomyces cerevisiae have been characterized for suppressibility by the following suppressors: UAA and UAG suppressors that insert tyrosine, serine or leucine; a putative UGA suppressor; an omnipotent suppressor SUP46; and a frameshift suppressor SUF1-1. In addition, the lys2 mutants...

journal_title：Genetics

authors： Chattoo BB,Palmer E,Ono B,Sherman F

更新日期：1979-09-01 00:00:00

abstract：:X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress and X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, a...

journal_title：Genetics

authors： Meneely PM,Nordstrom KD

更新日期：1988-06-01 00:00:00

abstract：:We have initiated an analysis of protein kinase A (PKA) in Drosophila using transgenic techniques to modulate PKA activity in specific tissues during development. We have constructed GAL4/UAS-regulated transgenes in active and mutant forms that encode PKAc, the catalytic subunit of PKA, and PKI(1-31), a competitive in...

journal_title：Genetics

authors： Kiger JA Jr,Eklund JL,Younger SH,O'Kane CJ

更新日期：1999-05-01 00:00:00

abstract：:The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chrom...

journal_title：Genetics

authors： Conley EJ,Nduati V,Gonzalez-Hernandez JL,Mesfin A,Trudeau-Spanjers M,Chao S,Lazo GR,Hummel DD,Anderson OD,Qi LL,Gill BS,Echalier B,Linkiewicz AM,Dubcovsky J,Akhunov ED,Dvorák J,Peng JH,Lapitan NL,Pathan MS,Nguyen HT

更新日期：2004-10-01 00:00:00

abstract：:The prune gene of Drosophila melanogaster is predicted to encode a phosphodiesterase. Null alleles of prune are viable but cause an eye-color phenotype. The abnormal wing discs gene encodes a nucleoside diphosphate kinase. Killer of prune is a missense mutation in the abnormal wing discs gene. Although it has no pheno...

journal_title：Genetics

authors： Provost E,Hersperger G,Timmons L,Ho WQ,Hersperger E,Alcazar R,Shearn A

更新日期：2006-01-01 00:00:00

abstract：:Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuati...

journal_title：Genetics

authors： Takahata N

更新日期：1987-05-01 00:00:00

abstract：:The standard slipped-strand mispairing (SSM) model for the formation of variable number tandem repeats (VNTRs) proposes that a few tandem repeats, produced by chance mutations, provide the "raw material" for VNTR expansion. However, this model is unlikely to explain the formation of VNTRs with long motifs (e.g., minis...

journal_title：Genetics

authors： Taylor JS,Breden F

更新日期：2000-07-01 00:00:00

abstract：:In fission yeast, the septation initiation network (SIN) is thought to promote cytokinesis by downstream activation of Rho1, a conserved GTPase that controls cell growth and division. Here we show that Etd1 and PP2A-Pab1, antagonistic regulators of SIN, are Rho1 regulators. Our genetic and biochemical studies indicate...

journal_title：Genetics

authors： Alcaide-Gavilán M,Lahoz A,Daga RR,Jimenez J

更新日期：2014-02-01 00:00:00

abstract：:To develop a catalog of regulatory sites in two major model organisms, Drosophila melanogaster and Caenorhabditis elegans, the modERN (model organism Encyclopedia of Regulatory Networks) consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecess...

journal_title：Genetics

authors： Kudron MM,Victorsen A,Gevirtzman L,Hillier LW,Fisher WW,Vafeados D,Kirkey M,Hammonds AS,Gersch J,Ammouri H,Wall ML,Moran J,Steffen D,Szynkarek M,Seabrook-Sturgis S,Jameel N,Kadaba M,Patton J,Terrell R,Corson M,Dur

更新日期：2018-03-01 00:00:00

abstract：:For multiallelic loci, standard measures of linkage disequilibrium provide an incomplete description of the correlation of variation at two loci, especially when there are different numbers of alleles at the two loci. We have developed a complementary pair of conditional asymmetric linkage disequilibrium (ALD) measure...

journal_title：Genetics

authors： Thomson G,Single RM

更新日期：2014-09-01 00:00:00

abstract：:Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as commercially important organisms. Gene targeting by homologous recombination during transformation is possible in A. nidulans, but the frequency of correct gene ta...

journal_title：Genetics

authors： Nayak T,Szewczyk E,Oakley CE,Osmani A,Ukil L,Murray SL,Hynes MJ,Osmani SA,Oakley BR

更新日期：2006-03-01 00:00:00

abstract：:A scheme for rapidly mapping chromosome rearrangements relative to the physical map of Caenorhabditis elegans is described that is based on hybridization patterns of cloned DNA on meiotic nuclei, as visualized by fluorescent in situ hybridization. From the nearly complete physical map, DNA clones, in yeast artificial ...

journal_title：Genetics

authors： Albertson DG

更新日期：1993-05-01 00:00:00

abstract：:Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...

journal_title：Genetics

authors： Ellis LL,Carney GE

更新日期：2011-01-01 00:00:00

abstract：:Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene of Drosophila exhibit delays in molting while stronger alleles are also larval lethal. In a freshly generated set of EM...

journal_title：Genetics

authors： Joshi R,Venkatesh K,Srinivas R,Nair S,Hasan G

更新日期：2004-01-01 00:00:00

abstract：:Escherichia coli K12 does not metabolize beta-glucosides such as arbutin and salicin because of lack of expression of the bglBSRC operon, which contains structural genes for transport (bglC) and hydrolysis (bglB) of phospho-beta-glucosides. Mutants carrying lesions in the cis-acting regulatory site bglR metabolize bet...

journal_title：Genetics

authors： Defez R,De Felice M

更新日期：1981-01-01 00:00:00

abstract：:Recombination and chromosome synapsis bring homologous chromosomes together, creating chiasmata that ensure accurate disjunction during reductional division. SPO13 is a key gene required for meiosis I (MI) reductional segregation, but dispensable for recombination, in Saccharomyces cerevisiae. Absence of SPO13 leads t...

journal_title：Genetics

authors： Rutkowski LH,Esposito RE

更新日期：2000-08-01 00:00:00

abstract：:A total of 568 new simple sequence repeat (SSR)-based markers for barley have been developed from a combination of database sequences and small insert genomic libraries enriched for a range of short simple sequence repeats. Analysis of the SSRs on 16 barley cultivars revealed variable levels of informativeness but no ...

journal_title：Genetics

authors： Ramsay L,Macaulay M,degli Ivanissevich S,MacLean K,Cardle L,Fuller J,Edwards KJ,Tuvesson S,Morgante M,Massari A,Maestri E,Marmiroli N,Sjakste T,Ganal M,Powell W,Waugh R

更新日期：2000-12-01 00:00:00

abstract：:Obtaining accurate estimates of the genetic covariance matrix Sigma(G) for multivariate data is a fundamental task in quantitative genetics and important for both evolutionary biologists and plant or animal breeders. Classical methods for estimating Sigma(G) are well known to suffer from substantial sampling errors; i...

journal_title：Genetics

authors： Meyer K,Kirkpatrick M

更新日期：2010-07-01 00:00:00

abstract：:Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved by two functionally similar but structurally distinct processes in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe In ...

journal_title：Genetics

authors： Hanson SJ,Wolfe KH

更新日期：2017-05-01 00:00:00

abstract：:The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by monitoring their relative abundance across time points in a si...

journal_title：Genetics

authors： Matuszewski S,Hildebrandt ME,Ghenu AH,Jensen JD,Bank C

更新日期：2016-09-01 00:00:00

abstract：:By screening for suppressors of hypomorphic mutations of let-23, a receptor tyrosine kinase necessary for vulval induction in Caenorhabditis elegans, we recovered > or = 12 mutations defining the sli-1 (suppressor of lineage defect) locus. sli-1 mutations suppress four of five phenotypes associated with hypomorphic al...

journal_title：Genetics

authors： Jongeward GD,Clandinin TR,Sternberg PW

更新日期：1995-04-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:In budding yeast, at least 10 proteins are required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Spo11 is the enzyme responsible for cleaving DNA and is found in a complex that also contains Ski8, Rec102, and Rec104. The Mre11/Rad50/Xrs2 complex is required for both DSB formati...

journal_title：Genetics

authors： Li J,Hooker GW,Roeder GS

更新日期：2006-08-01 00:00:00