Abstract:
:The standard slipped-strand mispairing (SSM) model for the formation of variable number tandem repeats (VNTRs) proposes that a few tandem repeats, produced by chance mutations, provide the "raw material" for VNTR expansion. However, this model is unlikely to explain the formation of VNTRs with long motifs (e.g., minisatellites), because the likelihood of a tandem repeat forming by chance decreases rapidly as the length of the repeat motif increases. Phylogenetic reconstruction of the birth of a mitochondrial (mt) DNA minisatellite in guppies suggests that VNTRs with long motifs can form as a consequence of SSM at noncontiguous repeats. VNTRs formed in this manner have motifs longer than the noncontiguous repeat originally formed by chance and are flanked by one unit of the original, noncontiguous repeat. SSM at noncontiguous repeats can therefore explain the birth of VNTRs with long motifs and the "imperfect" or "short direct" repeats frequently observed adjacent to both mtDNA and nuclear VNTRs.
journal_name
Geneticsjournal_title
Geneticsauthors
Taylor JS,Breden Fkeywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
1313-20issue
3eissn
0016-6731issn
1943-2631journal_volume
155pub_type
杂志文章相关文献
GENETICS文献大全abstract::Mapping quantitative trait loci in plants is usually conducted using a population derived from a cross between two inbred lines. The power of such QTL detection and the parameter estimates depend largely on the choice of the two parental lines. Thus, the QTL detected in such populations represent only a small part of ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.028993
更新日期:2004-11-01 00:00:00
abstract::Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::We studied microgeographic and temporal genetic differentiation in natural populations of Drosophila persimilis with respect to chromosome inversion and enzyme polymorphisms. Both inversion frequencies and allozyme frequencies varied significantly over short distances. Neither differed significantly between morning an...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::We have used mutational and revertant analysis to study the elements of the 54-nucleotide COX2 5'-untranslated leader involved in translation initiation in yeast mitochondria and in activation by the COX2 translational activator. Pet111p. We generated a collection of mutants with substitutions spanning the entire COX2...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::DNA sequence variation in a 1410-bp region including the Cu,Zn Sod locus was examined in 41 homozygous lines of Drosophila melanogaster. Fourteen lines were from Barcelona, Spain, 25 were from California populations and the other two were from laboratory stocks. Two common electromorphs, SODS and SODF, are segregating...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering approximately 77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verifi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.076216
更新日期:2007-09-01 00:00:00
abstract::The genetic basis of body weight in the mouse was investigated by measuring frequency changes of microsatellite marker alleles in lines divergently selected for body weight from a base population of a cross between two inbred strains. In several regions of the genome, sharp peaks of frequency change at linked markers ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Although the role of U1 small nuclear RNAs (snRNAs) in 5' splice site recognition is well established, suppressor U1 snRNAs active in intact multicellular animals have been lacking. Here we describe suppression of a 5' splice site mutation in the Drosophila melanogaster white gene (wDR18) by compensatory changes in U1...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::The sojourn times until fixation of an overdominant allele were investigated based on the diffusion equation. Furthermore, the rate of accumulation of mutations, or the substitution rate, was predicted from the mean extinction time of a common overdominant allele. The substitution rate calculated theoretically agreed ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::Extensive Monte Carlo simulations are conducted of spatial distributions of two-locus genotypes in large, continuous populations under isolation by distance models. The results show that substantial patches of double homozygotes are present in the spatial structures, even when loci are unlinked. The stochastic spread ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::We have isolated a new class of deletion mutants of phage lambda that extend from the prophage attachment site, att, into the gam and cIII genes. In this respect they are similar to certain of the lambda pbio transducing phage, but they differ in having a low burst size and in forming minute plaques. Lytically grown s...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::To investigate the genetic basis of maize adaptation to temperate climate, collections of 375 inbred lines and 275 landraces, representative of American and European diversity, were evaluated for flowering time under short- and long-day conditions. The inbred line collection was genotyped for 55 genomewide simple sequ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.048603
更新日期:2006-04-01 00:00:00
abstract::Mobile P elements in Drosophila melanogaster cause hybrid dysgenesis if their mobility is not repressed. One type of repression, termed P cytotype, is a complex interaction between chromosomes carrying P elements and cytoplasm and is transmitted through the cytoplasm only of females. Another type of repression is foun...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.158824
更新日期:2014-04-01 00:00:00
abstract::The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::A radiation-induced translocation, T(IIR----IIIL), has been shown to be nonreciprocal and to have most of IIR, including its terminus, attached uninverted to the terminus of IIIL.--Progeny with the IIR segment in duplicate, obtained from crosses of T(IIR----IIIL) to strains with a standard genome, were unstable at mit...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2 (Orm-1, Orm-2) relative to each other and to the reference genes brown (b), B-cell maturation factor responsiveness (Bmfr-1), and major urinary protein-1 (Mup-1...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::The small subunit ribosomal RNA gene (srDNA) has been used extensively for phylogenetic analyses. One common assumption in these analyses is that substitution rates are biased toward transitions. We have developed a simple method for estimating relative rates of base change that does not assume rate constancy and take...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.092775
更新日期:2008-12-01 00:00:00
abstract::Gametes are produced in plants through mitotic divisions in the haploid gametophytes. We investigated the role of EXPORTIN1 (XPO1) genes during the development of both female and male gametophytes of Arabidopsis. Exportins exclude target proteins from the nucleus and are also part of a complex recruited at the kinetoc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.094896
更新日期:2008-11-01 00:00:00
abstract::The RAD54 gene, which encodes a protein in the SWI2/SNF2 family, plays an important role in recombination and DNA repair in Saccharomyces cerevisiae. The yeast genome project revealed a homologue of RAD54, RDH54/TID1. Properties of the rdh54/tid1 mutant and the rad54 rdh54/tid1 double mutant are shown for mitosis and ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons of 14 sires and 206 genetic markers distributed across all 29 autosomes and flanking an estimated 2497 autosomal cM using Kosambi's mapping funct...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.073072
更新日期:2007-07-01 00:00:00
abstract::The Drosophila mei-S332 gene acts to maintain sister-chromatid cohesion before anaphase II of meiosis in both males and females. By isolating and analyzing seven new alleles and a deficiency uncovering the mei-S332 gene we have demonstrated that the onset of the requirement for mei-S332 is not until late anaphase I. A...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.082206
更新日期:2007-12-01 00:00:00
abstract::The point mutation rate of phage PhiX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0x10(-6) substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per roun...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106005
更新日期:2009-10-01 00:00:00
abstract::Genes with unstable transcripts often encode proteins that play important regulatory roles. ATL2 is a member of a multigene family coding highly related RING-H2 zinc-finger proteins that may function as E3 ubiquitin ligases. ATL2 mRNA accumulation occurs rapidly and transiently after incubation with elicitors of patho...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.028043
更新日期:2004-06-01 00:00:00
abstract::The decrease of meiotic exchanges (crossing over and conversion) in two mutants of Sordaria macrospora correlated strongly with a reduction of chiasmata and of both types of "recombination nodules." Serial section reconstruction electron microscopy was used to compare the synapsis pattern of meiotic prophase I in wild...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::In budding yeast, at least 10 proteins are required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Spo11 is the enzyme responsible for cleaving DNA and is found in a complex that also contains Ski8, Rec102, and Rec104. The Mre11/Rad50/Xrs2 complex is required for both DSB formati...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.058768
更新日期:2006-08-01 00:00:00