Point mutation rate of bacteriophage PhiX174.

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00

abstract：:The sex-ratio trait described in several Drosophila species is a type of naturally occurring X-linked meiotic drive that causes males bearing a sex-ratio X chromosome to produce progenies with a large excess of females. We have previously reported the occurrence of sex-ratio X chromosomes in Drosophila simulans. In th...

journal_title：Genetics

authors： Cazemajor M,Landré C,Montchamp-Moreau C

更新日期：1997-10-01 00:00:00

abstract：:The POL3 encoded catalytic subunit of DNA polymerase delta possesses a highly conserved C-terminal cysteine-rich domain in Saccharomyces cerevisiae. Mutations in some of its cysteine codons display a lethal phenotype, which demonstrates an essential function of this domain. The thermosensitive mutant pol3-13, in which...

journal_title：Genetics

authors： Giot L,Chanet R,Simon M,Facca C,Faye G

更新日期：1997-08-01 00:00:00

abstract：:Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...

journal_title：Genetics

authors： Myster SH,Wang F,Cavallo R,Christian W,Bhotika S,Anderson CT,Peifer M

更新日期：2004-02-01 00:00:00

abstract：:The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic con...

journal_title：Genetics

authors： Emmerich J,Meyer CA,de la Cruz AF,Edgar BA,Lehner CF

更新日期：2004-10-01 00:00:00

abstract：:Aggression is a complex social behavior that is widespread in nature. To date, only a limited number of genes that affect aggression have been identified, in large part because the complexity of the phenotype makes screening difficult and time-consuming regardless of the species that is studied. We discovered that agg...

journal_title：Genetics

authors： Davis SM,Thomas AL,Liu L,Campbell IM,Dierick HA

更新日期：2018-01-01 00:00:00

abstract：:Retroviruses and their relatives, the long terminal repeat (LTR) retrotransposons, carry out complex life cycles within the cells of their hosts. We have exploited a collection of gene deletion mutants developed by the Saccharomyces Genome Deletion Project to perform a functional genomics screen for host factors that ...

journal_title：Genetics

authors： Griffith JL,Coleman LE,Raymond AS,Goodson SG,Pittard WS,Tsui C,Devine SE

更新日期：2003-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...

journal_title：Genetics

authors： DiLeone RJ,Russell LB,Kingsley DM

更新日期：1998-01-01 00:00:00

abstract：:To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...

journal_title：Genetics

authors： Uemura H,Koshio M,Inoue Y,Lopez MC,Baker HV

更新日期：1997-10-01 00:00:00

abstract：:We examine the efficiency of different genotyping and phenotyping strategies in inbred line crosses from an information perspective. This provides a mathematical framework for the statistical aspects of QTL experimental design, while guiding our intuition. Our central result is a simple formula that quantifies the fra...

journal_title：Genetics

authors： Sen S,Satagopan JM,Churchill GA

更新日期：2005-05-01 00:00:00

abstract：:Intrachromosomal gene conversion is the non-reciprocal transfer of information between a pair of repeated genes on a single chromosome. This process produces eventual sequence homogeneity within a family of repeated genes. An evolutionary model for a single chromosome lineage was formulated and analyzed. Expressions w...

journal_title：Genetics

authors： Nagylaki T,Petes TD

更新日期：1982-02-01 00:00:00

abstract：:Spontaneous tandem chromosomal duplications are common in populations of Escherichia coli and Salmonella typhimurium. They range in frequency for a given locus from 10(-2) to 10(-4) and probably form by RecA-dependent unequal sister strand exchanges between repetitive sequences in direct order. Certain duplications ha...

journal_title：Genetics

authors： Haack KR,Roth JR

更新日期：1995-12-01 00:00:00

abstract：:Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transf...

journal_title：Genetics

authors： Hodgkin JA,Brenner S

更新日期：1977-06-01 00:00:00

abstract：:COTRANS is a program for analyzing cotransduction data. It calculates distances from pairwise cotransduction frequencies, computes crossovers required to obtain each observed recombinant class, and applies rules to draw conclusions about order. The rules are based on the correlation between the frequency of the classe...

journal_title：Genetics

authors： Berlyn MB,Letovsky S

更新日期：1992-05-01 00:00:00

abstract：:We studied the control of pharyngeal excitation in Caenorhabditis elegans. By laser ablating subsets of the pharyngeal nervous system, we found that the MC neuron type is necessary and probably sufficient for rapid pharyngeal pumping. Electropharyngeograms showed that MC transmits excitatory postsynaptic potentials, s...

journal_title：Genetics

authors： Raizen DM,Lee RY,Avery L

更新日期：1995-12-01 00:00:00

abstract：:Plants with mutations in one of three maize genes, mop1, rmr1, and rmr2, are defective in paramutation, an allele-specific interaction that leads to meiotically heritable chromatin changes. Experiments reported here demonstrate that these genes are required to maintain the transcriptional silencing of two different tr...

journal_title：Genetics

authors： McGinnis KM,Springer C,Lin Y,Carey CC,Chandler V

更新日期：2006-07-01 00:00:00

abstract：:The Acp26Aa and Acp26Ab genes that code for male accessory gland proteins are tandemly arranged in the species of the Drosophila melanogaster complex. An approximately 1.6-kb region encompassing both genes has been sequenced in 10, 24, and 18 lines from Spain, Ivory Coast, and Malawi, respectively; the previously stud...

journal_title：Genetics

authors： Aguadé M

更新日期：1998-11-01 00:00:00

abstract：:In plants, many major regulatory genes that control plant growth and development have been identified and characterized. Despite a detailed knowledge of the function of these genes little is known about how they contribute to the natural variation for complex traits. To determine whether major regulatory genes of maiz...

journal_title：Genetics

authors： Weber A,Clark RM,Vaughn L,Sánchez-Gonzalez Jde J,Yu J,Yandell BS,Bradbury P,Doebley J

更新日期：2007-12-01 00:00:00

abstract：:BTB-zinc finger transcription factors play many important roles in metazoan development. In these proteins, the BTB domain is critical for dimerization and for recruiting cofactors to target genes. Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. He...

journal_title：Genetics

authors： Howell K,Arur S,Schedl T,Sundaram MV

更新日期：2010-04-01 00:00:00

abstract：:Florida teosinte from Honduras and Guanajuato teosinte have most of their knobs internally located and a common inversion in the short arm of chromosome 8. Teosintes from northern Guatemala, Huixta and Monajil, have all their knobs terminally located and do not have any inversions. Therefore, Florida teosinte from Hon...

journal_title：Genetics

authors： Ting YC

更新日期：1976-08-01 00:00:00

abstract：:It is well known that an allele causing increased recombination is expected to proliferate as a result of genetic drift in a finite population undergoing selection, without requiring other mechanisms. This is supported by recent simulations apparently demonstrating that, in small populations, drift is more important t...

journal_title：Genetics

authors： Iles MM,Walters K,Cannings C

更新日期：2003-12-01 00:00:00

abstract：:The binding of alpha-factor to its receptor (Ste2p) activates a G-protein-signaling pathway leading to conjugation of MATa cells of the budding yeast S. cerevisiae. We conducted a genetic screen to identify constitutively activating mutations in the N-terminal region of the alpha-factor receptor that includes transmem...

journal_title：Genetics

authors： Parrish W,Eilers M,Ying W,Konopka JB

更新日期：2002-02-01 00:00:00

abstract：:Statistical associations between phenotypic traits often result from shared developmental processes and include both covariation between the trait values and more complex associations between higher moments of the joint distribution of traits. In this article, an analytical technique for calculating the covariance bet...

journal_title：Genetics

authors： Rice SH

更新日期：2004-01-01 00:00:00

abstract：:Quantitative traits whose phenotypic values change over time are called longitudinal traits. Genetic analyses of longitudinal traits can be conducted using any of the following approaches: (1) treating the phenotypic values at different time points as repeated measurements of the same trait and analyzing the trait und...

journal_title：Genetics

authors： Yang R,Tian Q,Xu S

更新日期：2006-08-01 00:00:00

abstract：:The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon s...

journal_title：Genetics

authors： Petersen L,Enos-Berlage J,Downs DM

更新日期：1996-05-01 00:00:00

abstract：:The change in frequencies of D. melanogaster and D. simulans in competition experiments was used to measure the effect of radiation on the fitness of a population. A dose of 250 or 500 rads given to the males of highly inbred lines of D. simulans at the beginning of competition and every three weeks thereafter increas...

journal_title：Genetics

authors： Blaylock BG,Shugart HH Jr

更新日期：1972-11-01 00:00:00

abstract：:The transmission of transposed Ac elements in progeny derived by self-pollination of ten transformed tomato plants has been examined by Southern hybridization analysis. We show that six of these primary transformants have transmitted a transposed Ac to at least one progeny. One of the families was segregating for at l...

journal_title：Genetics

authors： Belzile F,Lassner MW,Tong Y,Khush R,Yoder JI

更新日期：1989-09-01 00:00:00

abstract：:Genetically marked P elements inserted into the subtelomeric satellites of Drosophila show repression and variegation of the reporter gene. One such white+ reporter, inserted between the subtelomeric satellite and the terminal HeT-A array in the left arm of chromosome 2 (2L), is sensitive to its context; changes in th...

journal_title：Genetics

authors： Golubovsky MD,Konev AY,Walter MF,Biessmann H,Mason JM

更新日期：2001-07-01 00:00:00

abstract：:Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pom...

journal_title：Genetics

authors： Gao C,Langbein L,Kamal F,George AA,Walworth NC

更新日期：2017-10-01 00:00:00

abstract：:The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...

journal_title：Genetics

authors： Cooper MT,Conant AW,Kennison JA

更新日期：2010-07-01 00:00:00