Abstract：
:The change in frequencies of D. melanogaster and D. simulans in competition experiments was used to measure the effect of radiation on the fitness of a population. A dose of 250 or 500 rads given to the males of highly inbred lines of D. simulans at the beginning of competition and every three weeks thereafter increased the relative frequency of the irradiated population. If the dose was increased to 1000 rads, the deleterious effects of radiation became too great a burden on the population, and the frequency of the irradiated population decreased. From these results it was concluded that below certain doses the introduction of radiation-induced mutations into a highly homozygous population would increase the fitness of the population.
journal_name
Geneticsjournal_title
Geneticsauthors
Blaylock BG,Shugart HH Jrsubject
Has Abstractpub_date
1972-11-01 00:00:00pages
469-74issue
3eissn
0016-6731issn
1943-2631journal_volume
72pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.064063
更新日期：2007-03-01 00:00:00
abstract：:The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.199075
更新日期：2017-08-01 00:00:00
abstract：:Genic heterozygosity and variation were studied in the permanent translocation heterozygotes Oenothera biennis I, Oe. biennis II, Oe. biennis III, Oe. strigosa, Oe. parviflora I, Oe. parviflora II, and in the related bivalent formers Oe. argillicola and Oe. hookeri. From variation at 20 enzyme loci, we find that trans...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:During meiotic prophase, assembly of the synaptonemal complex (SC) brings homologous chromosomes into close apposition along their lengths. The Zip1 protein is a major building block of the SC in Saccharomyces cerevisiae. In the absence of Zip1, SC fails to form, cells arrest or delay in meiotic prophase (depending on...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.071100
更新日期：2007-06-01 00:00:00
abstract：:Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilit...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.163238
更新日期：2014-11-01 00:00:00
abstract：:Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity o...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.108.098244
更新日期：2008-12-01 00:00:00
abstract：:Epistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.041525
更新日期：2005-12-01 00:00:00
abstract：:I describe a method for simulating samples from gene families of size two under a neutral coalescent process, for the case where the duplicate gene either has fixed recently in the population or is still segregating. When a duplicate locus has recently fixed by genetic drift, diversity in the new gene is expected to b...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.074948
更新日期：2007-10-01 00:00:00
abstract：:The behaviour of two "meiotic drive" systems, Segregation-Distorter (SD) and the sex chromosome sc(4)sc(8) has been examined in the same meiocyte. It has been found that the two systems interact in a specific way. When the distorting effects of SD and sc(4)sc(8) are against each other, there is no detectable interacti...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1972-09-01 00:00:00
abstract：:The distribution within anthers of maize plants of microsporocytes of differing crossover class was studied by application of the serial-sectioning technique to plants heterozygous for a paracentric inversion. In such material, cells with four-strand double crossovers within the inversion are distinguishable from cell...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:Transcriptional silencing involves the formation of specialized repressive chromatin structures. Previous studies have shown that the histone H3-H4 chaperone known as chromatin assembly factor 1 (CAF-1) contributes to transcriptional silencing in yeast, although the molecular basis for this was unknown. In this work w...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.054783
更新日期：2006-06-01 00:00:00
abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Two parental strains of laboratory mice, NZB and CBA/H, were chosen for their differences in attack behavior. NZB have higher scores than CBA/H. An effect of the Y chromosome on attack behavior was determined for two maternal environments. Each male was tested once in a dyadic encounter with an A/J male as a standard ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:The vacuolar hydrolase protease B in Saccharomyces cerevisiae is synthesized as an inactive precursor (Prb1p). The precursor undergoes post-translational modifications while transiting the secretory pathway. In addition to N- and O-linked glycosylations, four proteolytic cleavages occur during the maturation of Prb1p....
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:We have found that temperature can have a striking effect upon protein export in Escherichia coli, suggesting that there is a cold-sensitive step in the protein export pathway. Cs mutations comprise the largest class of mutations affecting the membrane-localized Sec proteins SecD, SecE, SecF and SecY. Although some of...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:Identifying loci under natural selection from genomic surveys is of great interest in different research areas. Commonly used methods to separate neutral effects from adaptive effects are based on locus-specific population differentiation coefficients to identify outliers. Here we extend such an approach to estimate d...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.092221
更新日期：2008-10-01 00:00:00
abstract：:In eukaryotic cells, the organization of genomic DNA into chromatin regulates many biological processes, from the control of gene expression to the regulation of chromosome segregation. The proper maintenance of this structure upon cell division is therefore of prime importance during development for the maintenance o...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.190785
更新日期：2017-01-01 00:00:00
abstract：:The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased e...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:There are many types of DNA damage that are repaired by a multiplicity of different repair pathways. All damage and repair occur in the context of chromatin, and histone modifications are involved in many repair processes. We have analyzed the roles of H2A and its modifications in repair by mutagenizing modifiable res...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.063792
更新日期：2007-05-01 00:00:00
abstract：:Several eukaryotic homologs of the Escherichia coli RecQ DNA helicase have been found. These include the human BLM gene, whose mutation results in Bloom syndrome, and the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging. We cloned a Drosophila melanogaster homolog of the RECQ helicase...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Histone chaperones, chromatin remodelers, and histone modifying complexes play a critical role in alleviating the nucleosomal barrier for DNA-dependent processes. Here, we have examined the role of two highly conserved yeast (Saccharomyces cerevisiae) histone chaperones, facilitates chromatin transcription (FACT) and ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.300943
更新日期：2018-07-01 00:00:00
abstract：:Sex differences occur in most species and affect a variety of biological traits including morphology, behavior, and life history. The nematode Caenorhabditis elegans exists as a population of self-fertile hermaphrodites with occasional males, which differ anatomically and behaviorally from hermaphrodites. Here we show...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.056093
更新日期：2006-06-01 00:00:00
abstract：:Segregation distorter (SD) chromosomes are preferentially transmitted to offspring from heterozygous SD/SD(+) males owing to the induced dysfunction of the SD(+)-bearing sperm. This phenomenon involves at least two major loci: the Sd locus whose presence is necessary for distortion to occur and the Rsp locus which act...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:One of the key factors contributing to the success of a quantitative trait locus (QTL) mapping experiment is the precision with which QTL positions can be estimated. We show, using simulations, that QTL mapping precision for an experimental cross can be increased by the use of a genotypically selected sample of indivi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.033746
更新日期：2005-05-01 00:00:00
abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.117929
更新日期：2010-11-01 00:00:00
abstract：:The construction in bacteriophage lambda of a set of long DNA palindromes with paired changes in the central sequence is described. Identical palindrome centers were previously used by others to test the S-type model for cruciform extrusion in vitro. Long DNA palindromes prevent the propagation of carrier phage lambda...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Over 100 regulatory mutations linked to the histidine (his) operon of S. typhimurium have been isolated. They all map in a region estimated to be several hundred base pairs in length located at one end of the his operon ("the hisO region"). The mutations are located at sixteen recombinationally separable sites or are ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-10-01 00:00:00
abstract：:Smg1 is a key component of nonsense-mediated decay (NMD) in Caenorhabditis elegans and mammals. Here we report that two nonsense alleles of the ortholog of Smg1 do not affect NMD in Drosophila melanogaster. ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.045674
更新日期：2005-09-01 00:00:00
