Improving quantitative trait loci mapping resolution in experimental crosses by the use of genotypically selected samples.

abstract：:The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social ...

journal_title：Genetics

authors： Johnsson M,Henriksen R,Fogelholm J,Höglund A,Jensen P,Wright D

更新日期：2018-05-01 00:00:00

abstract：:Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3' strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison, little is known of the early events in the integrated mammalian system...

journal_title：Genetics

authors： Si W,Mundia MM,Magwood AC,Mark AL,McCulloch RD,Baker MD

更新日期：2010-06-01 00:00:00

abstract：:Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...

journal_title：Genetics

authors： Fine RD,Maqani N,Li M,Franck E,Smith JS

更新日期：2019-05-01 00:00:00

abstract：:Cell surface immunoglobulin superfamily (IgSF) proteins play important roles in the development and function of the nervous system . Here we define the role of a Caenorhabditis elegans IgSF protein, RIG-3, in the function of the AVA command interneuron. This study reveals that RIG-3 regulates the abundance of the glut...

journal_title：Genetics

authors： Bhardwaj A,Pandey P,Babu K

更新日期：2020-01-01 00:00:00

abstract：:The K1 killer plasmid, [KIL-k1], of Saccharomyces cerevisiae is a 1.25 x 10(6) dalton linear double-stranded RNA plasmid coding for a protein toxin and immunity to that toxin. The [KIL-sd1] plasmid is a replication-defective mutant of [KIL-k1] that depends on one of the recessive chromosomal superkiller (ski-) mutatio...

journal_title：Genetics

authors： Wickner RB,Toh-e A

更新日期：1982-02-01 00:00:00

abstract：:The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis. Kinetochore orientation is generated in part by a process of resolving kinetochores at the centromere (centromere resolution) prior to spindle interactions. Because few of the genes required for ce...

journal_title：Genetics

authors： Stanvitch G,Moore LL

更新日期：2008-01-01 00:00:00

abstract：:Competition among domesticated plants or animals can have a dramatic negative impact on yield of a stand or farm. The usual quantitative genetic model ignores these competitive interactions and could result in seriously incorrect breeding decisions and acerbate animal well-being. A general solution to this problem is ...

journal_title：Genetics

authors： Muir WM

更新日期：2005-07-01 00:00:00

abstract：:The ability of a virus population to colonize a novel host is predicted to depend on the equilibrium frequency of potential colonists (i.e., genotypes capable of infecting the novel host) in the source population. In this study, we investigated the determinants of the equilibrium frequency of potential colonists in th...

journal_title：Genetics

authors： Ferris MT,Joyce P,Burch CL

更新日期：2007-06-01 00:00:00

abstract：:Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the ...

journal_title：Genetics

authors： Yi N,Banerjee S,Pomp D,Yandell BS

更新日期：2007-07-01 00:00:00

abstract：:Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its capacity to produce secondary metabolites. Here, we report the role of the fungal-specific regulatory velvet complexes in development and secondary metabolism (SM) ...

journal_title：Genetics

authors： Bayram ÖS,Dettmann A,Karahoda B,Moloney NM,Ormsby T,McGowan J,Cea-Sánchez S,Miralles-Durán A,Brancini GTP,Luque EM,Fitzpatrick DA,Cánovas D,Corrochano LM,Doyle S,Selker EU,Seiler S,Bayram Ö

更新日期：2019-07-01 00:00:00

abstract：:There are two distinct reasons for making comparisons of genetic variation for quantitative characters. The first is to compare evolvabilities, or ability to respond to selection, and the second is to make inferences about the forces that maintain genetic variability. Measures of variation that are standardized by the...

journal_title：Genetics

authors： Houle D

更新日期：1992-01-01 00:00:00

abstract：:Twelve mutations affecting nuclear migration, a major developmental phase in Schizophyllum commune, display a complex pattern of complementation and recombination. They are expressed only when a genetic factor controlling this phase of development, the B incompatibility factor, is operative. All twelve mutations are l...

journal_title：Genetics

authors： Dubovoy C

更新日期：1976-03-01 00:00:00

abstract：:The Triplo-lethal locus (Tpl) is unique in its dosage sensitivity; no other locus in Drosophila has been identified that is lethal when present in three doses. Tpl is also haplo-lethal, and its function is still a mystery. Previous workers have found it nearly impossible to mutationally inactive Tpl other than by comp...

journal_title：Genetics

authors： Dorer DR,Christensen AC

更新日期：1990-08-01 00:00:00

abstract：:SNAP receptor (SNARE) and Sec1/Munc18 (SM) proteins are required for all intracellular membrane fusion events. SNAREs are widely believed to drive the fusion process, but the function of SM proteins remains unclear. To shed light on this, we screened for dominant-negative mutants of yeast Sec1 by random mutagenesis of...

journal_title：Genetics

authors： Boyd A,Ciufo LF,Barclay JW,Graham ME,Haynes LP,Doherty MK,Riesen M,Burgoyne RD,Morgan A

更新日期：2008-09-01 00:00:00

abstract：:Thirty-five nucleotide polymorphisms were found in a 21.5-kbp region including the Est6 locus among 42 isoallelic lines extracted from a single natural population of Drosophila melanogaster. The heterozygosity per nucleotide pair was estimated to be 0.010 overall, but was lower in sequences hybridizing to transcripts ...

journal_title：Genetics

authors： Game AY,Oakeshott JG

更新日期：1990-12-01 00:00:00

abstract：:Smg1 is a key component of nonsense-mediated decay (NMD) in Caenorhabditis elegans and mammals. Here we report that two nonsense alleles of the ortholog of Smg1 do not affect NMD in Drosophila melanogaster. ...

journal_title：Genetics

authors： Chen Z,Smith KR,Batterham P,Robin C

更新日期：2005-09-01 00:00:00

abstract：:Loss of heterozygosity (LOH) can be a driving force in the evolution of mitotic/somatic diploid cells, and cellular changes that increase the rate of LOH have been proposed to facilitate this process. In the yeast Saccharomyces cerevisiae, spontaneous LOH occurs by a number of mechanisms including chromosome loss and ...

journal_title：Genetics

authors： Andersen MP,Nelson ZW,Hetrick ED,Gottschling DE

更新日期：2008-07-01 00:00:00

abstract：:Neutrality tests based on the frequency spectrum (e.g., Tajima's D or Fu and Li's F) are commonly used by population geneticists as routine tests to assess the goodness-of-fit of the standard neutral model on their data sets. Here, I show that these neutrality tests are specific instances of a general model that encom...

journal_title：Genetics

authors： Achaz G

更新日期：2009-09-01 00:00:00

abstract：:To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...

journal_title：Genetics

authors： Uemura H,Koshio M,Inoue Y,Lopez MC,Baker HV

更新日期：1997-10-01 00:00:00

abstract：:Sixteen inbred or partially inbred strains of rabbits were investigated for electrophoretic and quantitative variations of alpha-1-antitrypsin (A-1-AT). We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-...

journal_title：Genetics

authors： Kueppers F,Lee CC,Fox RR,Mills JK

更新日期：1984-04-01 00:00:00

abstract：:Tetrahymena is a useful eukaryotic model for biochemistry and molecular cell biology studies. We previously demonstrated that targeted ectopic DNA elimination, also called co-Deletion (coDel), can be induced by the introduction of an internal eliminated sequence (IES)-target DNA chimeric construct. In this study, we d...

journal_title：Genetics

authors： Hayashi A,Mochizuki K

更新日期：2015-09-01 00:00:00

abstract：:OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for identifying conserved genes for research into biological and disease mechanisms. However, the efficacy of orthology prediction depends on th...

journal_title：Genetics

authors： Kim W,Underwood RS,Greenwald I,Shaye DD

更新日期：2018-10-01 00:00:00

abstract：:The binding of alpha-factor to its receptor (Ste2p) activates a G-protein-signaling pathway leading to conjugation of MATa cells of the budding yeast S. cerevisiae. We conducted a genetic screen to identify constitutively activating mutations in the N-terminal region of the alpha-factor receptor that includes transmem...

journal_title：Genetics

authors： Parrish W,Eilers M,Ying W,Konopka JB

更新日期：2002-02-01 00:00:00

abstract：:The cut gene in Drosophila is necessary in at least one cell type, the external sensory organs, for proper cell type specification and morphogenesis. It is also expressed in a variety of other tissues, where its function is less well characterized. Previous work has demonstrated that mutations affecting all the tissue...

journal_title：Genetics

authors： Liu S,McLeod E,Jack J

更新日期：1991-01-01 00:00:00

abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...

journal_title：Genetics

authors： Spiliopoulou A,Colombo M,Orchard P,Agakov F,McKeigue P

更新日期：2017-05-01 00:00:00

abstract：:Resident gut bacteria are constantly influencing the immune system, yet the role of the immune system in shaping microbiota composition during an organism's life span has remained unclear. Experiments in mice have been inconclusive due to differences in husbandry schemes that led to conflicting results. We used Drosop...

journal_title：Genetics

authors： Mistry R,Kounatidis I,Ligoxygakis P

更新日期：2017-06-01 00:00:00

abstract：:Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as commercially important organisms. Gene targeting by homologous recombination during transformation is possible in A. nidulans, but the frequency of correct gene ta...

journal_title：Genetics

authors： Nayak T,Szewczyk E,Oakley CE,Osmani A,Ukil L,Murray SL,Hynes MJ,Osmani SA,Oakley BR

更新日期：2006-03-01 00:00:00

abstract：:Electron microscope serial section reconstruction analysis of all zygotene-pachytene nuclei of meiotic cells from three wild-type germaria (a subunit of the ovary containing the early meiotic stages arrayed in temporal developmental sequence) of Drosophila melanogaster females corroborates and extends earlier observat...

journal_title：Genetics

authors： Carpenter AT

更新日期：1979-06-01 00:00:00

abstract：:The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profi...

journal_title：Genetics

authors： Gong WJ,Golic KG

更新日期：2006-01-01 00:00:00

abstract：:Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...

journal_title：Genetics

authors： Kingsbury DT,Sieckmann DG,Helinski DR

更新日期：1973-05-01 00:00:00