Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of Saccharomyces cerevisiae.

abstract：:Argonaute2 (Ago2) is a rapidly evolving nuclease in the Drosophila melanogaster RNA interference (RNAi) pathway that targets viruses and transposable elements in somatic tissues. Here we reconstruct the history of Ago2 duplications across the D. obscura group and use patterns of gene expression to infer new functional...

journal_title：Genetics

authors： Lewis SH,Webster CL,Salmela H,Obbard DJ

更新日期：2016-10-01 00:00:00

abstract：:Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...

journal_title：Genetics

authors： Watanabe S,Xia Z,Hideshima R,Tsubokura Y,Sato S,Yamanaka N,Takahashi R,Anai T,Tabata S,Kitamura K,Harada K

更新日期：2011-06-01 00:00:00

abstract：:Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons of 14 sires and 206 genetic markers distributed across all 29 autosomes and flanking an estimated 2497 autosomal cM using Kosambi's mapping funct...

journal_title：Genetics

authors： Zhang Q,Boichard D,Hoeschele I,Ernst C,Eggen A,Murkve B,Pfister-Genskow M,Witte LA,Grignola FE,Uimari P,Thaller G,Bishop MD

更新日期：1998-08-01 00:00:00

abstract：:The parasitoid wasp Nasonia vitripennis is an emerging model organism for developmental and behavioral genetics. It reproduces by haplodiploidy; males typically develop parthenogenetically from haploid eggs and females from fertilized diploid eggs. A polyploid mutant strain is available in which females are triploid a...

journal_title：Genetics

authors： Beukeboom LW,Kamping A

更新日期：2006-02-01 00:00:00

abstract：:We develop a maximum penalized-likelihood (MPL) method to estimate the fitnesses of amino acids and the distribution of selection coefficients (S = 2Ns) in protein-coding genes from phylogenetic data. This improves on a previous maximum-likelihood method. Various penalty functions are used to penalize extreme estimate...

journal_title：Genetics

authors： Tamuri AU,Goldman N,dos Reis M

更新日期：2014-05-01 00:00:00

abstract：:Mutations in the Saccharomyces cerevisiae SPT8 gene were previously isolated as suppressors of retrotransposon insertion mutations in the 5' regions of the HIS4 and LYS2 genes. Mutations in SPT8 confer phenotypes similar to those caused by particular mutations in SPT15, which encodes the TATA-binding protein (TBP). Th...

journal_title：Genetics

authors： Eisenmann DM,Chapon C,Roberts SM,Dollard C,Winston F

更新日期：1994-07-01 00:00:00

abstract：:In order to define more precisely the most proximal portion of chromosome 3R in Drosophila melanogaster, several new chromosome aberrations involving this region have been recovered and analyzed. These new arrangements were recovered as induced reversions of two dominant mutations, ANTPNs and dsxD, located in the regi...

journal_title：Genetics

authors： Duncan IW,Kaufman TC

更新日期：1975-08-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:A long-standing prediction in evolutionary biology is that organisms experience a so-called "cost of complexity" manifested as a decreasing rate of adaptation in populations as organisms or selective environments become increasingly complex. This theory assumes the ubiquity of antagonistic pleiotropy, or trade-offs in...

journal_title：Genetics

authors： Sackman AM,Rokyta DR

更新日期：2019-05-01 00:00:00

abstract：:The L-shaped distribution of estimated QTL effects (R(2)) has long been reported. We recently showed that a metabolic mechanism could account for this phenomenon. But other nonexclusive genetic or nongenetic causes may contribute to generate such a distribution. Using analysis and simulations of an additive genetic mo...

journal_title：Genetics

authors： Bost B,de Vienne D,Hospital F,Moreau L,Dillmann C

更新日期：2001-04-01 00:00:00

abstract：:Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP kinase (MAPK) pathways are essential for communicat...

journal_title：Genetics

authors： Fischer MS,Wu VW,Lee JE,O'Malley RC,Glass NL

更新日期：2018-06-01 00:00:00

abstract：:Automated image acquisition, a custom analysis algorithm, and a distributed computing resource were used to add time as a third dimension to a quantitative trait locus (QTL) map for plant root gravitropism, a model growth response to an environmental cue. Digital images of Arabidopsis thaliana seedling roots from two ...

journal_title：Genetics

authors： Moore CR,Johnson LS,Kwak IY,Livny M,Broman KW,Spalding EP

更新日期：2013-11-01 00:00:00

abstract：:The dmd gene of bacteriophage T4 is required for regulation of mRNA stability in a stage-dependent manner during infection. When this gene is mutated, late genes are globally silenced because of rapid degradation of mRNAs. To investigate the mechanism of such mRNA degradation, we analyzed the late gene soc transcripts...

journal_title：Genetics

authors： Kai T,Yonesaki T

更新日期：2002-01-01 00:00:00

abstract：:Very few mutations derived from Mutator maize lines have been studied at the molecular level. The variety of Mu elements that can induce mutations, the relative frequency of mutant induction by insertion of a given class of Mu elements or by a Mu-induced genomic rearrangement, a possible intragenic insertion site spec...

journal_title：Genetics

authors： Brown WE,Robertson DS,Bennetzen JL

更新日期：1989-06-01 00:00:00

abstract：:Seventeen lines, each homozygous for a different X chromosome but all with a common autosomal genetic blackground, were constructed and assayed for abdominal bristle number to determine whether dosage compensation operates for sex-linked genes affecting this character. --The regression coefficient of male mean on fema...

journal_title：Genetics

authors： Frankham R

更新日期：1977-01-01 00:00:00

abstract：:Because some metabolic intermediates are involved in more than one pathway, crosstalk between pathways is crucial to maintaining homeostasis. AMP and histidine biosynthesis pathways are coregulated at the transcriptional level in response to adenine availability. 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR...

journal_title：Genetics

authors： Rébora K,Laloo B,Daignan-Fornier B

更新日期：2005-05-01 00:00:00

abstract：:Protein serine/threonine phosphatase type 1 (PP1) has been found in all eukaryotes examined to date and is involved in the regulation of many cellular functions, including glycogen metabolism, muscle contraction, and mitosis. In Drosophila, four genes code for the catalytic subunit of PP1 (PP1c), three of which belong...

journal_title：Genetics

authors： Kirchner J,Gross S,Bennett D,Alphey L

更新日期：2007-05-01 00:00:00

abstract：:The primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptide...

journal_title：Genetics

authors： Akashi H

更新日期：2003-08-01 00:00:00

abstract：:Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) controlling deviation on the X chromosome and...

journal_title：Genetics

authors： Montagutelli X,Turner R,Nadeau JH

更新日期：1996-08-01 00:00:00

abstract：:Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...

journal_title：Genetics

authors： Ellis LL,Carney GE

更新日期：2011-01-01 00:00:00

abstract：:It is well known that most new mutations that affect fitness exert deleterious effects and that natural populations are often composed of subpopulations (demes) connected by gene flow. To gain a better understanding of the joint effects of purifying selection and population structure, we focus on a scenario where an a...

journal_title：Genetics

authors： Zeng K,Corcoran P

更新日期：2015-12-01 00:00:00

abstract：:Ribosome biogenesis is tightly regulated through stress-sensing pathways that impact genome stability, aging and senescence. In Saccharomyces cerevisiae, ribosomal RNAs are transcribed from rDNA located on the right arm of chromosome XII. Numerous studies reveal that rDNA decondenses into a puff-like structure during ...

journal_title：Genetics

authors： Shen D,Skibbens RV

更新日期：2020-03-01 00:00:00

abstract：:In eukaryotic cells, the organization of genomic DNA into chromatin regulates many biological processes, from the control of gene expression to the regulation of chromosome segregation. The proper maintenance of this structure upon cell division is therefore of prime importance during development for the maintenance o...

journal_title：Genetics

authors： Roelens B,Clémot M,Leroux-Coyau M,Klapholz B,Dostatni N

更新日期：2017-01-01 00:00:00

abstract：:A total of 568 new simple sequence repeat (SSR)-based markers for barley have been developed from a combination of database sequences and small insert genomic libraries enriched for a range of short simple sequence repeats. Analysis of the SSRs on 16 barley cultivars revealed variable levels of informativeness but no ...

journal_title：Genetics

authors： Ramsay L,Macaulay M,degli Ivanissevich S,MacLean K,Cardle L,Fuller J,Edwards KJ,Tuvesson S,Morgante M,Massari A,Maestri E,Marmiroli N,Sjakste T,Ganal M,Powell W,Waugh R

更新日期：2000-12-01 00:00:00

abstract：:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection ...

journal_title：Genetics

authors： Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TF

更新日期：2004-04-01 00:00:00

abstract：:We analyzed the dynamics of transposable elements (TEs) according to Wright's island and continent-island models, assuming that selection tends to counter the deleterious effects of TEs. We showed that migration between host populations has no impact on either the existence or the stability of the TE copy number equil...

journal_title：Genetics

authors： Deceliere G,Charles S,Biémont C

更新日期：2005-01-01 00:00:00

abstract：:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...

journal_title：Genetics

authors： Turner BC

更新日期：1977-03-01 00:00:00

abstract：:The behavior of chromosomal inversions in Escherichia coli depends upon the region they affect. Regions flanking the replication terminus have been termed nondivisible zones (NDZ) because inversions ending in the region were either deleterious or not feasible. This regional phenomenon is further analyzed here. Thirty ...

journal_title：Genetics

authors： Guijo MI,Patte J,del Mar Campos M,Louarn JM,Rebollo JE

更新日期：2001-04-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of pro...

journal_title：Genetics

authors： Fang Q,Longo-Guess C,Gagnon LH,Mortensen AH,Dolan DF,Camper SA,Johnson KR

更新日期：2011-10-01 00:00:00