Abstract：
:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection due to a trade-off in resource allocation between reproductive activity and individual survival. Knowledge of the genes affecting starvation tolerance and the subset of genes that affect variation in starvation resistance in natural populations would enable us to evaluate this hypothesis from a quantitative genetic perspective. We screened 933 co-isogenic P-element insertion lines to identify candidate genes affecting starvation tolerance. A total of 383 P-element insertions induced highly significant and often sex-specific mutational variance in starvation resistance. We also used deficiency complementation mapping followed by complementation to mutations to identify 12 genes contributing to variation in starvation resistance between two wild-type strains. The genes we identified are involved in oogenesis, metabolism, and feeding behaviors, indicating a possible link to reproduction and survival. However, we also found genes with cell fate specification and cell proliferation phenotypes, which implies that resource allocation during development and at the cellular level may also influence the phenotypic response to starvation.
journal_name
Geneticsjournal_title
Geneticsauthors
Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TFdoi
10.1534/genetics.166.4.1807keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
1807-23issue
4eissn
0016-6731issn
1943-2631pii
166/4/1807journal_volume
166pub_type
杂志文章相关文献
GENETICS文献大全abstract：:The region containing subdivisions 93C, 93D and 93E on chromosome 3 of Drosophila melanogaster has been screened for visible and lethal mutations. Treatment with three mutagens, gamma irradiation, ethyl methanesulfonate and diepoxybutane, has produced mutations that fall into 20 complementation groups, including the p...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.300977
更新日期：2018-06-01 00:00:00
abstract：:Tetrazolium oxidase from the blood and liver of rainbow trout was found to be genetically polymorphic. The inheritance pattern of the liver enzyme was compatible only with a one locus-two allele hypothesis. The enzymes in the blood while having an electrophoretically identical polymorphism could differ genotypically f...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1972-10-01 00:00:00
abstract：:The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chrom...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.034801
更新日期：2004-10-01 00:00:00
abstract：:Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.062976
更新日期：2007-01-01 00:00:00
abstract：:Spontaneous tandem chromosomal duplications are common in populations of Escherichia coli and Salmonella typhimurium. They range in frequency for a given locus from 10(-2) to 10(-4) and probably form by RecA-dependent unequal sister strand exchanges between repetitive sequences in direct order. Certain duplications ha...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Insulin-like growth factors (IGFs) control cell and organism growth through evolutionarily conserved signaling pathways. The mammalian acid-labile subunit (ALS) is a secreted protein that complexes with IGFs to modulate their activity. Recent work has shown that a Drosophila homolog of ALS, dALS, can also complex with...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.099531
更新日期：2009-04-01 00:00:00
abstract：:A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosome...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:In response to an external source of adenine, yeast cells repress the expression of purine biosynthesis pathway genes. To identify necessary components of this signalling mechanism, we have isolated mutants that are constitutively active for expression. These mutants were named bra (for bypass of repression by adenine...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable expressivity of traits. Although quantitative trait locus (QTL) analysis has been a powerful tool for localizing the ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.090175
更新日期：2008-12-01 00:00:00
abstract：:The Drosophila PS1 and PS2 integrins are required to maintain the connection between the dorsal and ventral wing epithelia. If alphaPS subunits are inappropriately expressed during early pupariation, the epithelia separate, causing a wing blister. Two lines of evidence indicate that this apparent loss-of-function phen...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.117440
更新日期：2010-09-01 00:00:00
abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.080879
更新日期：2008-02-01 00:00:00
abstract：:The genetics of the ciliate Tetrahymena thermophila are richer than for most other eukaryotic cells, because Tetrahymena possesses two genomes: a germline (micronuclear) genome that follows a Mendelian model of genetic transmission and a somatic (macronuclear) genome, derived from the micronuclear genome by fragmentat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-s...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301747
更新日期：2019-01-01 00:00:00
abstract：:Differentiation in morphometric traits among experimental populations of the housefly subjected to an experimental bottleneck was examined for replicate lines founded with one, four or 16 pairs of flies. Differentiation among lines within a bottleneck size was significantly greater than predicted by drift in relation ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：:Recessive lethal or semilethal alleles at the T/t locus in the mouse generate new t-variants, with characteristics different from the parent allele at a rate of about 10(-3). Almost invariably the variant chromosome carries marker genes derived from the opposite parental chromosome. New t-mutations obtained in this wa...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1976-06-01 00:00:00
abstract：:The developmental gene optomotor-blind (omb) encodes a T-box-containing transcription factor that has multiple roles in Drosophila development. Previous genetic analyses established that omb plays a key role in establishing the abdominal pigmentation pattern of Drosophila melanogaster. In this report we examine patter...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.032078
更新日期：2004-12-01 00:00:00
abstract：:Restriction fragment length polymorphisms in mitochondrial DNA (mtDNA) were used to reconstruct evolutionary relationships of conspecific populations in four species of freshwater fish-Amia calva, Lepomis punctatus, L. gulosus, and L. microlophus. A suite of 14-17 endonucleases was employed to assay mtDNAs from 305 sp...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：:BTB-zinc finger transcription factors play many important roles in metazoan development. In these proteins, the BTB domain is critical for dimerization and for recruiting cofactors to target genes. Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. He...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.111591
更新日期：2010-04-01 00:00:00
abstract：:Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.159988
更新日期：2014-05-01 00:00:00
abstract：:The hitchhiking model of population genetics predicts that an allele favored by Darwinian selection can replace haplotypes from the same locus previously established at a neutral mutation-drift equilibrium. This process, known as "selective sweep," was studied by comparing molecular variation between the polymorphic I...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:Much of the material taken into cells by endocytosis is rapidly returned to the plasma membrane by the endocytic recycling pathway. Although recycling is vital for the correct localization of cell membrane receptors and lipids, the molecular mechanisms that regulate recycling are only partially understood. Here we sho...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.087247
更新日期：2008-05-01 00:00:00
abstract：:We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.160697
更新日期：2014-03-01 00:00:00
abstract：:This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.165035
更新日期：2014-08-01 00:00:00
abstract：:The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period, a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302890
更新日期：2020-02-01 00:00:00
abstract：:Restriction map variation in two 5-6-kb chloroplast DNA regions of five diploid Aegilops species in the section Sitopsis and two wild tetraploid wheats, Triticum dicoccoides and Triticum araraticum, was investigated with a battery of four-cutter restriction enzymes. A single accession each of Triticum durum, Triticum ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.048793
更新日期：2006-01-01 00:00:00
abstract：:Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.033878
更新日期：2004-12-01 00:00:00
abstract：:In(2LR)PL is a large pericentric inversion polymorphic in populations of Drosophila melanogaster on two Indian Ocean islands. This polymorphism is puzzling: because crossing over in female heterokaryotypes produces inviable zygotes, such inversions are thought to be underdominant and should be quickly eliminated from ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
