Mutational Analysis of the Region Surrounding the 93d Heat Shock Locus of DROSOPHILA MELANOGASTER.

abstract：:High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...

journal_title：Genetics

authors： Bates KL,Higley M,Letsou A

更新日期：2008-04-01 00:00:00

abstract：:This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screeni...

journal_title：Genetics

authors： Eberl DF,Hilliker AJ

更新日期：1988-01-01 00:00:00

abstract：:We consider inference for demographic models and parameters based upon postprocessing the output of an MCMC method that generates samples of genealogical trees (from the posterior distribution for a specific prior distribution of the genealogy). This approach has the advantage of taking account of the uncertainty in t...

journal_title：Genetics

authors： Meligkotsidou L,Fearnhead P

更新日期：2007-09-01 00:00:00

abstract：:The distribution of fitness effects (DFE) of new mutations is of fundamental importance in evolutionary genetics. Recently, methods have been developed for inferring the DFE that use information from the allele frequency distributions of putatively neutral and selected nucleotide polymorphic variants in a population s...

journal_title：Genetics

authors： Schneider A,Charlesworth B,Eyre-Walker A,Keightley PD

更新日期：2011-12-01 00:00:00

abstract：:Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "parti...

journal_title：Genetics

authors： Thomas-Orillard M,Jeune B,Cusset G

更新日期：1995-08-01 00:00:00

abstract：:R1 and R2 elements are non-LTR retrotransposons that insert specifically into the 28S rRNA genes of arthropods. The process of concerted evolution of the rDNA locus should give rise to rapid turnover of these mobile elements compared to elements that insert at sites throughout a genome. To estimate the rate of R1 and ...

journal_title：Genetics

authors： Pérez-González CE,Eickbush TH

更新日期：2002-10-01 00:00:00

abstract：:Although neurons are highly polarized, how neuronal polarity is generated remains poorly understood. An evolutionarily conserved inositol-producing enzyme myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic molecules in Caenorhabditis elegans and can be inhibited by lithium, a dru...

journal_title：Genetics

authors： Kimata T,Tanizawa Y,Can Y,Ikeda S,Kuhara A,Mori I

更新日期：2012-06-01 00:00:00

abstract：:In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence...

journal_title：Genetics

authors： Diaz-Perez S,Ouyang Y,Perez V,Cisneros R,Regelson M,Marahrens Y

更新日期：2005-10-01 00:00:00

abstract：:We examine the influence of nonrandom mating and immigration on the evolutionary dynamics of cytonuclear associations in hybrid zones. Recursion equations for allelic and genotypic cytonuclear disequilibria were generated under models of (1) migration alone, assuming hybrid zone matings are random with respect to cyto...

journal_title：Genetics

authors： Asmussen MA,Arnold J,Avise JC

更新日期：1989-08-01 00:00:00

abstract：:A gene encoding a Ustilago maydis Rad51 orthologue has been isolated, rad51-1, a mutant constructed by disrupting the gene, was as sensitive to killing by ultraviolet light and gamma radiation as the rec2-1 mutant and slightly more sensitive to killing by methyl methanesulfonate. There was no suppression of killing by...

journal_title：Genetics

authors： Ferguson DO,Rice MC,Rendi MH,Kotani H,Kmiec EB,Holloman WK

更新日期：1997-02-01 00:00:00

abstract：:Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microsco...

journal_title：Genetics

authors： Simon F,Ramat A,Louvet-Vallée S,Lacoste J,Burg A,Audibert A,Gho M

更新日期：2019-07-01 00:00:00

abstract：:Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression. The mutations e(y)1u1, e(y)3u1, and to a lesser extent e(y)2u1, enhance the effect of the zeste null allele zv77h. Different combinations of e(y)1u1, e(y)2u1 and e(y)3u1...

journal_title：Genetics

authors： Georgiev PG

更新日期：1994-11-01 00:00:00

abstract：:The behaviour of two "meiotic drive" systems, Segregation-Distorter (SD) and the sex chromosome sc(4)sc(8) has been examined in the same meiocyte. It has been found that the two systems interact in a specific way. When the distorting effects of SD and sc(4)sc(8) are against each other, there is no detectable interacti...

journal_title：Genetics

authors： Miklos GL,Yanders AF,Peacock WJ

更新日期：1972-09-01 00:00:00

abstract：:We develop a maximum penalized-likelihood (MPL) method to estimate the fitnesses of amino acids and the distribution of selection coefficients (S = 2Ns) in protein-coding genes from phylogenetic data. This improves on a previous maximum-likelihood method. Various penalty functions are used to penalize extreme estimate...

journal_title：Genetics

authors： Tamuri AU,Goldman N,dos Reis M

更新日期：2014-05-01 00:00:00

abstract：:We have characterized Unstable factor for orange1 (Ufo1), a dominant, allele-specific modifier of expression of the maize pericarp color1 (p1) gene. The p1 gene encodes an Myb-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The P1-wr allele specifies colorless kerne...

journal_title：Genetics

authors： Chopra S,Cocciolone SM,Bushman S,Sangar V,McMullen MD,Peterson T

更新日期：2003-03-01 00:00:00

abstract：:The Saccharomyces cerevisiae mitochondrial endonuclease I-SceI creates a double-strand break as the initiating step in the gene conversional transfer of the omega+ intron to omega- DNA. We have expressed a galactose-inducible synthetic I-SceI gene in the nucleus of yeast that also carries the I-SceI recognition site o...

journal_title：Genetics

authors： Plessis A,Perrin A,Haber JE,Dujon B

更新日期：1992-03-01 00:00:00

abstract：:The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...

journal_title：Genetics

authors： Borden D,Miller ET,Nanney DL,Whitt GS

更新日期：1973-08-01 00:00:00

abstract：:How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understood. In Drosophila, p...

journal_title：Genetics

authors： Kerwin SK,Li JSS,Noakes PG,Shin GJ,Millard SS

更新日期：2018-02-01 00:00:00

abstract：:Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To understand and correct these defects, we will need to identify the physiologically relevant substrates of these enzymes. The work presented here describes a nov...

journal_title：Genetics

authors： Deminoff SJ,Howard SC,Hester A,Warner S,Herman PK

更新日期：2006-08-01 00:00:00

abstract：:Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous re...

journal_title：Genetics

authors： Singer JB,Hill AE,Nadeau JH,Lander ES

更新日期：2005-02-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:The genetic etiology of many complex diseases is highly heterogeneous. A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci. Although these disease-susceptibility mutations can be collectively common in the population, they are often individu...

journal_title：Genetics

authors： Li M,He Z,Tong X,Witte JS,Lu Q

更新日期：2018-10-01 00:00:00

abstract：:Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently, we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the population but then,...

journal_title：Genetics

authors： Sellis D,Kvitek DJ,Dunn B,Sherlock G,Petrov DA

更新日期：2016-07-01 00:00:00

abstract：:Yeast cells subjected to a reversible thermal arrest of meiosis yielded progressively fewer spores per ascus as the arrest was extended. Dissection of two-spored asci by a newly developed method that prevents selection of false asci revealed that the spores were not a random sample of the haploid meiotic products. Mos...

journal_title：Genetics

authors： Davidow LS,Goetsch L,Byers B

更新日期：1980-03-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...

journal_title：Genetics

authors： Malavazi I,Lima JF,de Castro PA,Savoldi M,de Souza Goldman MH,Goldman GH

更新日期：2008-02-01 00:00:00

abstract：:A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selecti...

journal_title：Genetics

authors： Andolfatto P,Przeworski M

更新日期：2001-06-01 00:00:00

abstract：:The maize ligule is an adaxial membranous structure on the leaf that develops at the boundary of the sheath and blade. The ligule and the associated auricle are dispensable structures, amenable to genetic manipulation. We present here a genetic analysis of liguleless1 (lg1) and liguleless2 (lg2), the two genes known t...

journal_title：Genetics

authors： Harper L,Freeling M

更新日期：1996-12-01 00:00:00

abstract：:Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...

journal_title：Genetics

authors： LaFave MC,Varshney GK,Vemulapalli M,Mullikin JC,Burgess SM

更新日期：2014-09-01 00:00:00

abstract：:Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sle...

journal_title：Genetics

authors： Flavell SW,Raizen DM,You YJ

更新日期：2020-10-01 00:00:00