Abstract:
:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, evolutionary and population genetics, and other fields. With more tissue types and observable behaviors than in other short-generation model organisms, and with vast genome data available for many species within the genus, the fly's tractable complexity will continue to enable exciting opportunities to explore mechanisms of complex developmental programs, behaviors, and broader evolutionary questions. This primer describes the organism's natural history, the features of sequenced genomes within the genus, the wide range of available genetic tools and online resources, the types of biological questions Drosophila can help address, and historical milestones.
journal_name
Geneticsjournal_title
Geneticsauthors
Hales KG,Korey CA,Larracuente AM,Roberts DMdoi
10.1534/genetics.115.183392subject
Has Abstractpub_date
2015-11-01 00:00:00pages
815-42issue
3eissn
0016-6731issn
1943-2631pii
201/3/815journal_volume
201pub_type
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