Genetic Dissection of Hybrid Male Sterility Across Stages of Spermatogenesis.

abstract：:The nuclear aod-1 gene of Neurospora crassa encodes the alternative oxidase and is induced when the standard cytochrome-mediated respiratory chain of mitochondria is inhibited. To study elements of the pathway responsible for alternative oxidase induction, we generated a series of mutations in the region upstream from...

journal_title：Genetics

authors： Chae MS,Lin CC,Kessler KE,Nargang CE,Tanton LL,Hahn LB,Nargang FE

更新日期：2007-04-01 00:00:00

abstract：:A strain of Caenorhabditis elegans was constructed that permits selection of dominant or sex-linked mutations that transform XO animals (normally male) into fertile females, using a feminizing mutation, tra-2(e2046gf), which by itself does not sexually transform XO males. Twenty-three mutations were isolated after che...

journal_title：Genetics

authors： Hodgkin J,Albertson DG

更新日期：1995-10-01 00:00:00

abstract：:Methods for inference and interpretation of evolutionary quantitative genetic parameters, and for prediction of the response to selection, are best developed for traits with normal distributions. Many traits of evolutionary interest, including many life history and behavioral traits, have inherently nonnormal distribu...

journal_title：Genetics

authors： de Villemereuil P,Schielzeth H,Nakagawa S,Morrissey M

更新日期：2016-11-01 00:00:00

abstract：:The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

journal_title：Genetics

authors： Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

更新日期：2010-07-01 00:00:00

abstract：:Mathematical models are presented for the evolution of postmating and premating reproductive isolation. In the case of postmating isolation it is assumed that hybrid sterility or inviability is caused by incompatibility of alleles at one or two loci, and evolution of reproductive isolation occurs by random fixation of...

journal_title：Genetics

authors： Nei M,Maruyama T,Wu CI

更新日期：1983-03-01 00:00:00

abstract：:This work demonstrates that environmental conditions experienced by individuals can shape their development and affect the stability of genetic associations. The implication of this observation is that the environmental response may influence the evolution of traits in the wild. Here, we examined how the genetic archi...

journal_title：Genetics

authors： Robinson MR,Wilson AJ,Pilkington JG,Clutton-Brock TH,Pemberton JM,Kruuk LE

更新日期：2009-04-01 00:00:00

abstract：:The cut gene in Drosophila is necessary in at least one cell type, the external sensory organs, for proper cell type specification and morphogenesis. It is also expressed in a variety of other tissues, where its function is less well characterized. Previous work has demonstrated that mutations affecting all the tissue...

journal_title：Genetics

authors： Liu S,McLeod E,Jack J

更新日期：1991-01-01 00:00:00

abstract：:We have characterized Unstable factor for orange1 (Ufo1), a dominant, allele-specific modifier of expression of the maize pericarp color1 (p1) gene. The p1 gene encodes an Myb-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The P1-wr allele specifies colorless kerne...

journal_title：Genetics

authors： Chopra S,Cocciolone SM,Bushman S,Sangar V,McMullen MD,Peterson T

更新日期：2003-03-01 00:00:00

abstract：:Conditional lethal mutant systems developed in T-even bacteriophages T2, T4 and T6 have been used to study the partial exclusion which characterizes mixed infections of these phages. In bacteria mixedly infected with T2 and T4, the dominant phage (T4) acts against localized exclusion sensitivity determinants in the ge...

journal_title：Genetics

authors： Russell RL,Huskey RJ

更新日期：1974-12-01 00:00:00

abstract：:We define a new gene, SRD1, involved in the processing of pre-rRNA to mature rRNA. The SRD1 gene was identified by selecting for second-site suppressors of the previously described rrp1-1 mutation. The rrp1-1 mutation causes temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S...

journal_title：Genetics

authors： Fabian GR,Hess SM,Hopper AK

更新日期：1990-03-01 00:00:00

abstract：:Tetrahymena is a useful eukaryotic model for biochemistry and molecular cell biology studies. We previously demonstrated that targeted ectopic DNA elimination, also called co-Deletion (coDel), can be induced by the introduction of an internal eliminated sequence (IES)-target DNA chimeric construct. In this study, we d...

journal_title：Genetics

authors： Hayashi A,Mochizuki K

更新日期：2015-09-01 00:00:00

abstract：:Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers o...

journal_title：Genetics

authors： Buroker NE,Brown JR,Gilbert TA,O'Hara PJ,Beckenbach AT,Thomas WK,Smith MJ

更新日期：1990-01-01 00:00:00

abstract：:We report the isolation, characterization and analysis of the small subunit rRNA genes in Plasmodium cynomolgi (Ceylon). As in other Plasmodium species, these genes are present in low copy number, are unlinked and form two types that are distinct in sequence and are expressed stage specifically. The asexually expresse...

journal_title：Genetics

authors： Corredor V,Enea V

更新日期：1994-03-01 00:00:00

abstract：:The white-apricot (wa) allele differs from the wild-type white gene by the presence of the retrovirus-like transposable element copia within the transcription unit. Most RNAs derived from wa have 3' termini within this insertion, and only small amounts of structurally normal RNA are produced. The activity of wa is red...

journal_title：Genetics

authors： Peng XB,Mount SM

更新日期：1990-12-01 00:00:00

abstract：:A point connecting a pair of homologous regions of DNA duplexes moves along the homology in a reaction intermediate of the homologous recombination. Formulating this movement as a random walk, we were previously successful at explaining the dependence of the recombination frequency on the homology length. Recently, th...

journal_title：Genetics

authors： Fujitani Y,Kobayashi I

更新日期：1999-12-01 00:00:00

abstract：:Neutrality tests based on the frequency spectrum (e.g., Tajima's D or Fu and Li's F) are commonly used by population geneticists as routine tests to assess the goodness-of-fit of the standard neutral model on their data sets. Here, I show that these neutrality tests are specific instances of a general model that encom...

journal_title：Genetics

authors： Achaz G

更新日期：2009-09-01 00:00:00

abstract：:The accumulation of slightly deleterious mutations in populations leads to the buildup of a genetic load and can cause the extinction of populations of small size. Mutation-accumulation experiments have been used to study this process in a wide variety of organisms, yet the exact mutational underpinnings of genetic lo...

journal_title：Genetics

authors： Soll SJ,Díaz Arenas C,Lehman N

更新日期：2007-01-01 00:00:00

abstract：:Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To understand and correct these defects, we will need to identify the physiologically relevant substrates of these enzymes. The work presented here describes a nov...

journal_title：Genetics

authors： Deminoff SJ,Howard SC,Hester A,Warner S,Herman PK

更新日期：2006-08-01 00:00:00

abstract：:It has been hypothesized that the ratio of X-linked to autosomal sequence diversity is influenced by unequal sex ratios in Drosophila melanogaster populations. We conducted a genome scan of single nucleotide polymorphism (SNP) of 378 autosomal loci in a derived European population and of a subset of 53 loci in an ance...

journal_title：Genetics

authors： Hutter S,Li H,Beisswanger S,De Lorenzo D,Stephan W

更新日期：2007-09-01 00:00:00

abstract：:The ade6-M26 mutation of Schizosaccharomyces pombe has previously been reported to stimulate ade6 intragenic meiotic recombination. We report here that the ade6-M26 mutation is a single G----T nucleotide change, that M26 stimulated recombination within ade6 but not at other distinct loci, and that M26 stimulated meiot...

journal_title：Genetics

authors： Ponticelli AS,Sena EP,Smith GR

更新日期：1988-07-01 00:00:00

abstract：:We have developed defined genetic lines of the hydroid Hydractinia symbiolongicarpus and confirmed earlier results showing that allorecognition is controlled by a single chromosomal region within these lines. In a large backcross population, we detected recombinants that display a fusibility phenotype distinct from ty...

journal_title：Genetics

authors： Cadavid LF,Powell AE,Nicotra ML,Moreno M,Buss LW

更新日期：2004-05-01 00:00:00

abstract：:Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. The detection of positive selection can also help identify functionally important protein regions and thus guide protein engineering. Many existing tests for positive selection ar...

journal_title：Genetics

authors： Wagner A

更新日期：2007-08-01 00:00:00

abstract：:We have examined the stability of the tandemly repeated genes that encode the ribosomal RNA in Coprinus cinereus. These genes are contained within two linked HindIII fragments in a 3.0-Mb chromosome. We monitored the size of these fragments in both mitotic and meiotic segregants using the contour-clamped homogeneous e...

journal_title：Genetics

authors： Pukkila PJ,Skrzynia C

更新日期：1993-02-01 00:00:00

abstract：:A method for the estimation of population dynamic history from sequence data is described and used to investigate the past population dynamics of HIV-1 subtypes A and B. Using both gag and env gene alignments the effective population size of each subtype is estimated and found to be surprisingly small. This may be a r...

journal_title：Genetics

authors： Grassly NC,Harvey PH,Holmes EC

更新日期：1999-02-01 00:00:00

abstract：:We consider the effect on the distribution of pairwise differences between mitochondrial DNA sequences of the incorporation into the underlying population genetics model of two particular effects that seem realistic for human populations. The first is that the population size was roughly constant before growing to its...

journal_title：Genetics

authors： Marjoram P,Donnelly P

更新日期：1994-02-01 00:00:00

abstract：:An approximately 135-bp sequence called the A1/A2 repeat was isolated from the transcribed region of the 26-18S rDNA intergenic spacer (IGS) of Nicotiana tomentosiformis. Fluorescence in situ hybridization (FISH) and Southern blot analysis revealed its occurrence as an independent satellite (termed an A1/A2 satellite)...

journal_title：Genetics

authors： Lim KY,Skalicka K,Koukalova B,Volkov RA,Matyasek R,Hemleben V,Leitch AR,Kovarik A

更新日期：2004-04-01 00:00:00

abstract：:We isolated egl-13 mutants in which the pi cells of the Caenorhabditis elegans uterus initially appeared to develop normally but then underwent an extra round of cell division. The data suggest that egl-13 is required for maintenance of the pi cell fate. ...

journal_title：Genetics

authors： Cinar HN,Richards KL,Oommen KS,Newman AP

更新日期：2003-11-01 00:00:00

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:A family of protein kinases regulates translation in response to different cellular stresses by phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2alpha). In yeast, an eIF-2alpha kinase, GCN2, functions in translational control in response to amino acid starvation. It is thought that uncharge...

journal_title：Genetics

authors： Sood R,Porter AC,Olsen DA,Cavener DR,Wek RC

更新日期：2000-02-01 00:00:00

abstract：:Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were...

journal_title：Genetics

authors： Curtis D,Bender W

更新日期：1991-04-01 00:00:00