Abstract:
:We present the results of a restriction site survey of variation at five loci in Drosophila athabasca, complimenting a previous study of the period locus. There is considerably greater differentiation between the three semispecies of D. athabasca at the period locus and two other X-linked genes (no-on-transient-A and E74A) than at three autosomal genes (Xdh, Adh and RC98). Using a modification of the HKA test, which uses fixed differences between the semispecies and a test based on differences in Fst among loci, we show that the greater differentiation of the X-linked loci compared with the autosomal loci is inconsistent with a neutral model of molecular evolution. We explore several evolutionary scenarios by computer simulation, including differential migration of X and autosomal genes, very low levels of migration among the semispecies, selective-sweeps, and background selection, and conclude that X-linked selective sweeps in at least two of the semispecies are the best explanation for the data. This evidence that natural selection acted on the X-chromosome suggests that another X-linked trait, mating song differences among the semispecies, may have been the target of selection.
journal_name
Geneticsjournal_title
Geneticsauthors
Ford MJ,Aquadro CFsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
689-703issue
2eissn
0016-6731issn
1943-2631journal_volume
144pub_type
杂志文章相关文献
GENETICS文献大全abstract::We have characterized the MPH1 gene from Saccharomyces cerevisiae. mph1 mutants display a spontaneous mutator phenotype. Homologs were found in archaea and in the EST libraries of Drosophila, mouse, and man. Mph1 carries the signature motifs of the DEAH family of helicases. Selected motifs were shown to be necessary f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster....
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-11-01 00:00:00
abstract::The accumulation of slightly deleterious mutations in populations leads to the buildup of a genetic load and can cause the extinction of populations of small size. Mutation-accumulation experiments have been used to study this process in a wide variety of organisms, yet the exact mutational underpinnings of genetic lo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.066142
更新日期:2007-01-01 00:00:00
abstract::Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and shorter fragments that seed exte...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.130831
更新日期:2011-09-01 00:00:00
abstract::The F(1) hybrids of Nicotiana suaveolens (subgenus Petunioides, 2n = 32) and N. glutinosa (subgenus Tabacum, 2n = 24), were examined during their development, from seedlings to mature plants. It was observed that in the hybrids, there was a progressive change of dominant N. glutinosa morphological characteristics towa...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-04-01 00:00:00
abstract::Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.158824
更新日期:2014-04-01 00:00:00
abstract::While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117200
更新日期:2010-08-01 00:00:00
abstract::We present a genetic map based on microsatellite polymorphisms for the African human malaria vector, Anopheles gambiae. Polymorphisms in laboratory strains were detected for 89% of the tested microsatellite markers. Genotyping was performed for individual mosquitos from 13 backcross families that included 679 progeny....
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::Thirty-four independent nonviable c-locus mutations (types cal, albino lethal and cas, albino subvital), derived from radiation experiments, were tested for involvement of nearby markers tp, Mod-2, sh-1, and Hbb: 10, 22, and 2 involved, respectively, none of these markers, Mod-2 alone, and Mod-2 plus sh-1. When classi...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.089433
更新日期:2008-11-01 00:00:00
abstract::Mitotic interconversion of the mating-type locus (mat1) of the fission yeast Schizosaccharomyces pombe is initiated by a double-strand break at mat1. The mat2 and mat3 loci act as nonrandom donors of genetic information for mat1 switching such that switches occur primarily (or only) to the opposite mat1 allele. Locati...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::The endoplasmic reticulum (ER) is an extensive organelle in neurons with important roles at synapses including the regulation of cytosolic Ca2+, neurotransmission, lipid metabolism, and membrane trafficking. Despite intriguing evidence for these crucial functions, how the presynaptic ER influences synaptic physiology ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300261
更新日期:2017-11-01 00:00:00
abstract::BTB-zinc finger transcription factors play many important roles in metazoan development. In these proteins, the BTB domain is critical for dimerization and for recruiting cofactors to target genes. Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. He...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.111591
更新日期:2010-04-01 00:00:00
abstract::The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of translation. EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both translation factors are found in S. pombe and H. sapie...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.037473
更新日期:2005-04-01 00:00:00
abstract::Transcriptional silencing involves the formation of specialized repressive chromatin structures. Previous studies have shown that the histone H3-H4 chaperone known as chromatin assembly factor 1 (CAF-1) contributes to transcriptional silencing in yeast, although the molecular basis for this was unknown. In this work w...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.054783
更新日期:2006-06-01 00:00:00
abstract::Many genetic variants identified in genome-wide association studies (GWAS) are associated with multiple, sometimes seemingly unrelated, traits. This motivates multi-trait association analyses, which have successfully identified novel associated loci for many complex diseases. While appealing, most existing methods foc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303242
更新日期:2020-08-01 00:00:00
abstract::To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations o...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.301935
更新日期:2019-03-01 00:00:00
abstract::Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.166769
更新日期:2014-09-01 00:00:00
abstract::137Cs-gamma irradiation of bacteriophage T4 induces large deletions plus a variety of types of point mutations. All mutations arise with single-hit kinetics, and all by a misrepair process. The estimated point mutation rate is 1.5 X 10(-9) per locus per rad. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::Conifers are the predominant gymnosperm. The size and complexity of their genomes has presented formidable technical challenges for whole-genome shotgun sequencing and assembly. We employed novel strategies that allowed us to determine the loblolly pine (Pinus taeda) reference genome sequence, the largest genome assem...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.159715
更新日期:2014-03-01 00:00:00
abstract::The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.147983
更新日期:2013-02-01 00:00:00
abstract::In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178160
更新日期:2015-12-01 00:00:00
abstract::Sex-specific differences in dispersal, survival, reproductive success, and natural selection differentially affect the effective population size (N(e)) of genomic regions with different modes of inheritance such as sex chromosomes and mitochondrial DNA. In papionin monkeys (macaques, baboons, geladas, mandrills, drill...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.116228
更新日期:2010-07-01 00:00:00
abstract::RNAs are localized by microtubule-based pathways to both the anterior and posterior poles of the developing Drosophila oocyte. We describe a new gene, wispy, required for localization of mRNAs to both poles of the egg. Embryos from wispy mothers arrest development after abnormal oocyte meiosis and failure of pronuclei...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::This report examines five different naturally occurring alcohol dehydrogenase-1 alleles via the recombinational behavior of Adh1(-) mutants induced within them. Twenty-two biochemically characterized Adh1(-) mutants have been assessed for ability to recombine intragenically, using data generated by specifically staini...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::The purpose of this study was to characterize two mutator stocks of yeast which were induced and selected on the basis of high spontaneous reversion rates of the suppressible "ochre" nonsense allele lys1-1. In the mutator stock VA-3, a single mutation, designated mut1-1, is responsible for the increase in the reversio...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1976-08-01 00:00:00
abstract::We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling thos...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.128744
更新日期:2011-08-01 00:00:00
abstract::This paper describes a perturbation experiment on the frequency of the F and S Alcohol dehydrogenase (Adh) alleles of D. melanogaster. Fifty-four iso-female lines set up from three wild populations and with initial F frequencies of either 0.25, 0.50 or 0.75 were maintained on standard laboratory food medium at 22 degr...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Genetically marked P elements inserted into the subtelomeric satellites of Drosophila show repression and variegation of the reporter gene. One such white+ reporter, inserted between the subtelomeric satellite and the terminal HeT-A array in the left arm of chromosome 2 (2L), is sensitive to its context; changes in th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection exper...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303668
更新日期:2020-11-01 00:00:00