Abstract：
:Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced to a depth of ∼50×. Within this strain, we have identified the majority of the genome that matches the reference sequence and documented most of the variants. This strain has utility for many reasons, but in particular it will be useful for any researcher who needs to know the exact sequence (with all variants) of a particular genomic region or who wants to be able to robustly map sequences back to a genome with all possible variants defined.
journal_name
Geneticsjournal_title
Geneticsauthors
LaFave MC,Varshney GK,Vemulapalli M,Mullikin JC,Burgess SMdoi
10.1534/genetics.114.166769subject
Has Abstractpub_date
2014-09-01 00:00:00pages
167-70issue
1eissn
0016-6731issn
1943-2631pii
genetics.114.166769journal_volume
198pub_type
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