Abstract：
:The robustness of parametric linkage mapping against model misspecification is considered in experimental breeding designs, with a focus on localization of the gene. By examining the expected LOD across the genome, it is shown that single-gene models are quite robust, even for polygenic traits. However, when the marker map is of low resolution, linked polygenes can give rise to an apparent "ghost" gene, mapped to an incorrect interval. The results apply equally well to quantitative traits or qualitative (categorical) traits. The results are derived for backcross populations, with a discussion of extensions to intercross populations and relative-pair mapping in humans.
journal_name
Geneticsjournal_title
Geneticsauthors
Wright FA,Kong Asubject
Has Abstractpub_date
1997-05-01 00:00:00pages
417-25issue
1eissn
0016-6731issn
1943-2631journal_volume
146pub_type
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