Extragenic bypass suppressors of mutations in the essential gene BLD2 promote assembly of basal bodies with abnormal microtubules in Chlamydomonas reinhardtii.

abstract：:Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and shorter fragments that seed exte...

journal_title：Genetics

authors： Ozdowski EF,Gayle S,Bao H,Zhang B,Sherwood NT

更新日期：2011-09-01 00:00:00

abstract：:Development of the Caenorhabditis elegans foregut (pharynx) is regulated by a network of proteins that includes the Retinoblastoma protein (pRb) ortholog LIN-35; the ubiquitin pathway components UBC-18 and ARI-1; and PHA-1, a cytoplasmic protein. Loss of pha-1 activity impairs pharyngeal development and body morphogen...

journal_title：Genetics

authors： Polley SR,Kuzmanov A,Kuang J,Karpel J,Lažetić V,Karina EI,Veo BL,Fay DS

更新日期：2014-01-01 00:00:00

abstract：:We leverage two complementary Drosophila melanogaster mapping panels to genetically dissect starvation resistance-an important fitness trait. Using >1600 genotypes from the multiparental Drosophila Synthetic Population Resource (DSPR), we map numerous starvation stress QTL that collectively explain a substantial fract...

journal_title：Genetics

authors： Everman ER,McNeil CL,Hackett JL,Bain CL,Macdonald SJ

更新日期：2019-04-01 00:00:00

abstract：:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a populatio...

journal_title：Genetics

authors： Huang K,Mi R,Dunn DW,Wang T,Li B

更新日期：2018-12-01 00:00:00

abstract：:In a recent not in this journal (MARUYAMA 1973), one of us has considered, for a certain genetic model, the variance of the distribution of the number of loci having a given gene frequency. The formula given is incorrect. This brief note considers this problem and notes the correct solution in one particular case. ...

journal_title：Genetics

authors： Ewens WJ

更新日期：1975-05-01 00:00:00

abstract：:Correlation and regression analyses indicate that isofemale strains extracted from a population of the parasitic wasp, Nasonia vitripennis, differ in the fit of their second sex ratios (those produced in previously parasitized hosts) to the predictions of the theory of optimal facultative sex ratio adjustment. Under t...

journal_title：Genetics

authors： Orzack SH

更新日期：1990-02-01 00:00:00

abstract：:Dauer formation in Caenorhabditis elegans is induced by chemosensation of high levels of a constitutively secreted pheromone. Seven genes defined by mutations that confer a dauer-formation constitutive phenotype (Daf-c) can be congruently divided into two groups by any of three criteria. Group 1 genes (daf-11 and daf-...

journal_title：Genetics

authors： Thomas JH,Birnby DA,Vowels JJ

更新日期：1993-08-01 00:00:00

abstract：:Electron microscope serial section reconstruction analysis of all zygotene-pachytene nuclei of meiotic cells from three wild-type germaria (a subunit of the ovary containing the early meiotic stages arrayed in temporal developmental sequence) of Drosophila melanogaster females corroborates and extends earlier observat...

journal_title：Genetics

authors： Carpenter AT

更新日期：1979-06-01 00:00:00

abstract：:The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating...

journal_title：Genetics

authors： Demirel PB,Keyes BE,Chaterjee M,Remington CE,Burke DJ

更新日期：2012-10-01 00:00:00

abstract：:Two composite multiple regression-interval mapping analyses were performed to identify candidate quantitative trait loci (QTL) affecting components of wing shape in Drosophila melanogaster defined by eight relative warp-based measures. A recombinant inbred line design was used to map QTL for the shape of two intervein...

journal_title：Genetics

authors： Zimmerman E,Palsson A,Gibson G

更新日期：2000-06-01 00:00:00

abstract：:Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...

journal_title：Genetics

authors： Heasley LR,Watson RA,Argueso JL

更新日期：2020-09-01 00:00:00

abstract：:Statistical tests of the neutrality hypothesis that are based on the sampling theory of Ewens (1972) require the assumption of panmixia. It is proposed that for a population comprising numerous local populations with weak gene flow among them, tests based on Ewens' theory can be applied separately to samples from each...

journal_title：Genetics

authors： Slatkin M

更新日期：1982-03-01 00:00:00

abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...

journal_title：Genetics

authors： Birkner M,Blath J,Eldon B

更新日期：2013-01-01 00:00:00

abstract：:The Thomas Hunt Morgan Medal is awarded to an individual Genetics Society of America member for lifetime achievement in the field of genetics. It recognizes the full body of work of an exceptional geneticist. The 2016 recipient is Nancy Kleckner, who has made many significant contributions to our understanding of chro...

journal_title：Genetics

authors： Kleckner N

更新日期：2016-12-01 00:00:00

abstract：:We examine the efficiency of different genotyping and phenotyping strategies in inbred line crosses from an information perspective. This provides a mathematical framework for the statistical aspects of QTL experimental design, while guiding our intuition. Our central result is a simple formula that quantifies the fra...

journal_title：Genetics

authors： Sen S,Satagopan JM,Churchill GA

更新日期：2005-05-01 00:00:00

abstract：:Mitochondrial complex I is the largest multimeric enzyme of the respiratory chain. The lack of a model system with facile genetics has limited the molecular dissection of complex I assembly. Using Chlamydomonas reinhardtii as an experimental system to screen for complex I defects, we isolated, via forward genetics, am...

journal_title：Genetics

authors： Barbieri MR,Larosa V,Nouet C,Subrahmanian N,Remacle C,Hamel PP

更新日期：2011-06-01 00:00:00

abstract：:The Triplo-lethal locus (Tpl) is unique in its dosage sensitivity; no other locus in Drosophila has been identified that is lethal when present in three doses. Tpl is also haplo-lethal, and its function is still a mystery. Previous workers have found it nearly impossible to mutationally inactive Tpl other than by comp...

journal_title：Genetics

authors： Dorer DR,Christensen AC

更新日期：1990-08-01 00:00:00

abstract：:The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis. Kinetochore orientation is generated in part by a process of resolving kinetochores at the centromere (centromere resolution) prior to spindle interactions. Because few of the genes required for ce...

journal_title：Genetics

authors： Stanvitch G,Moore LL

更新日期：2008-01-01 00:00:00

abstract：:Protein serine/threonine phosphatase type 1 (PP1) has been found in all eukaryotes examined to date and is involved in the regulation of many cellular functions, including glycogen metabolism, muscle contraction, and mitosis. In Drosophila, four genes code for the catalytic subunit of PP1 (PP1c), three of which belong...

journal_title：Genetics

authors： Kirchner J,Gross S,Bennett D,Alphey L

更新日期：2007-05-01 00:00:00

abstract：:Transcription is repressed in regions of the fission yeast genome close to centromeres, telomeres, or the silent mating-type cassettes mat2-P and mat3-M. The repression involves the chromo-domain proteins Swi6 and Clr4. We report that two other chromo-domain proteins, Chp1 and Chp2, are also important for these positi...

journal_title：Genetics

authors： Thon G,Verhein-Hansen J

更新日期：2000-06-01 00:00:00

abstract：:The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor (Egfrtm1Mag) in mice is strongly dependent on genetic background. Initial attempts to genetically map background modifiers using Swiss-derived, outbred CD-1 mice were unsuccessful. To investigate the genetic archit...

journal_title：Genetics

authors： Strunk KE,Amann V,Threadgill DW

更新日期：2004-08-01 00:00:00

abstract：:The genetics of the ciliate Tetrahymena thermophila are richer than for most other eukaryotic cells, because Tetrahymena possesses two genomes: a germline (micronuclear) genome that follows a Mendelian model of genetic transmission and a somatic (macronuclear) genome, derived from the micronuclear genome by fragmentat...

journal_title：Genetics

authors： Wickert S,Nangle L,Shevel S,Orias E

更新日期：2000-03-01 00:00:00

abstract：:Thirty-five nucleotide polymorphisms were found in a 21.5-kbp region including the Est6 locus among 42 isoallelic lines extracted from a single natural population of Drosophila melanogaster. The heterozygosity per nucleotide pair was estimated to be 0.010 overall, but was lower in sequences hybridizing to transcripts ...

journal_title：Genetics

authors： Game AY,Oakeshott JG

更新日期：1990-12-01 00:00:00

abstract：:Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...

journal_title：Genetics

authors： Baker RE,Rogers K

更新日期：2006-11-01 00:00:00

abstract：:Ribosome biogenesis requires at least 18 putative ATP-dependent RNA helicases in Saccharomyces cerevisiae. To explore the functional environment of one of these putative RNA helicases, Dbp6p, we have performed a synthetic lethal screen with dbp6 alleles. We have previously characterized the nonessential Rsa1p, whose n...

journal_title：Genetics

authors： de la Cruz J,Lacombe T,Deloche O,Linder P,Kressler D

更新日期：2004-04-01 00:00:00

abstract：:There is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate vesicular protein trafficking, have additional roles in regulating transcription factors at the endosome. We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 or its associa...

journal_title：Genetics

authors： Gaur NA,Hasek J,Brickner DG,Qiu H,Zhang F,Wong CM,Malcova I,Vasicova P,Brickner JH,Hinnebusch AG

更新日期：2013-03-01 00:00:00

abstract：:Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...

journal_title：Genetics

authors： Chen CZ,Calero M,DeRegis CJ,Heidtman M,Barlowe C,Collins RN

更新日期：2004-12-01 00:00:00

abstract：:While evolution of coding sequences has been intensively studied, diversification of noncoding regulatory regions remains poorly understood. In this study, we investigated the molecular evolution of an enhancer region located 5 kb upstream of the transcription start site of the maize pericarp color1 (p1) gene. The p1 ...

journal_title：Genetics

authors： Zhang F,Peterson T

更新日期：2006-10-01 00:00:00

abstract：:Sister-chromatid exchanges (SCE) were studied in allium cepa L. meristematic cells at the second and third divisions after BrdUrd-substitution during just the first or during the second and third cycles, respectively. The observed SCE nonreciprocal/reciprocal ratios detected at the third division in both experiments, ...

journal_title：Genetics

authors： Schvartzman JB,Cortés F,González-Fernández A,Gutiérrez C,López-Sáez JF

更新日期：1979-08-01 00:00:00

abstract：:A subset of cancers rely on telomerase-independent mechanisms to maintain their chromosome ends. The predominant "alternative lengthening of telomeres" pathway appears dependent on homology-directed repair (HDR) to maintain telomeric DNA. However, the molecular changes needed for cells to productively engage in telome...

journal_title：Genetics

authors： Hu Y,Bennett HW,Liu N,Moravec M,Williams JF,Azzalin CM,King MC

更新日期：2019-10-01 00:00:00