Abstract:
:Statistical tests of the neutrality hypothesis that are based on the sampling theory of Ewens (1972) require the assumption of panmixia. It is proposed that for a population comprising numerous local populations with weak gene flow among them, tests based on Ewens' theory can be applied separately to samples from each local population. At low levels of gene flow, migration acts primarily like mutation, introducing new alleles to each local population. It is shown with simulation results that, at low levels of migration, correlations in allele frequencies among demes are sufficiently small that the results from the application of Ewens' theory to each deme are statistically independent. It is also shown that, by combining the results of the tests in different demes, some statistical power to detect deviations from neutrality is gained. The method is illustrated with the application to data on a salamander species. At low levels of gene flow, population subdivision must be taken account of in testing neutrality and the proposed test provides one way to do so.
journal_name
Geneticsjournal_title
Geneticsauthors
Slatkin Msubject
Has Abstractpub_date
1982-03-01 00:00:00pages
533-45issue
3eissn
0016-6731issn
1943-2631journal_volume
100pub_type
杂志文章相关文献
GENETICS文献大全abstract::In mismatch repair (MMR), members of the MLH gene family have been proposed to act as key molecular matchmakers to coordinate mismatch recognition with downstream repair functions that result in mispair excision. Two members of this gene family, MLH1 and MLH3, have also been implicated in meiotic crossing over. These ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.181438
更新日期:2016-03-01 00:00:00
abstract::Differential gene expression across cell types underlies development and cell physiology in multicellular organisms. Caenorhabditis elegans is a powerful, extensively used model to address these biological questions. A remaining bottleneck relates to the difficulty to obtain comprehensive tissue-specific gene transcri...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303774
更新日期:2020-12-01 00:00:00
abstract::Frequent nonhomologous recombination has been previously postulated to explain the 1045-bp insertion in one mitochondrial sperm-transmitted haplotype of Mytilus galloprovincialis. Such recombination would lead to the disruption of gene order and so the existence of a specific mechanism for maintaining the same gene or...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.065698
更新日期:2007-02-01 00:00:00
abstract::Data are presented concerning the gene arrangements in both arms of the X-chromosome of Drosophila robusta in eight altitudinal transects. The major change appears to be the increase of gene arrangement XL-1 (and decrease in XL, sometimes also XL-2) with increasing altitude. In each transect only one combination of XL...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract::The genetics of the ciliate Tetrahymena thermophila are richer than for most other eukaryotic cells, because Tetrahymena possesses two genomes: a germline (micronuclear) genome that follows a Mendelian model of genetic transmission and a somatic (macronuclear) genome, derived from the micronuclear genome by fragmentat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1 regulates Adr1 is unkno...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.103432
更新日期:2009-07-01 00:00:00
abstract::Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.106.057281
更新日期:2006-10-01 00:00:00
abstract::The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.039024
更新日期:2005-09-01 00:00:00
abstract::In lytic cycle crosses with Red-Gam-lambda phage, particles were examined that had undergone an Int-mediated exchange. It was assumed that this exchange dimerized the circular lambda, making it packageable. Among these Int-mediated recombinants, particles were identified that had, in addition, enjoyed a close double e...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract::As an ancient segmental tetraploid, the maize (Zea mays L.) genome contains large numbers of paralogs that are expected to have diverged by a minimum of 10% over time. Nearly identical paralogs (NIPs) are defined as paralogous genes that exhibit > or = 98% identity. Sequence analyses of the "gene space" of the maize i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.064006
更新日期:2007-01-01 00:00:00
abstract::The external genitalia are some of the most rapidly evolving morphological structures in insects. The posterior lobe of the male genital arch shows striking differences in both size and shape among closely related species of the Drosophila melanogaster species subgroup. Here, we dissect the genetic basis of posterior ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.130815
更新日期:2011-09-01 00:00:00
abstract::The Genetics Society of America's (GSA) Edward Novitski Prize is awarded to researchers who have solved challenging problems in genetics through experiments that demonstrate exceptional creativity and ingenuity. Job Dekker of the University of Massachusetts Medical School has been selected for the 2018 award in recogn...
journal_title:Genetics
pub_type: 传,历史文章,杂志文章
doi:10.1534/genetics.118.301641
更新日期:2018-11-01 00:00:00
abstract::In yeast, 17 histidine-requiring mutants derived from and interallelically complementary to his1-7 were analyzed. The genetic basis of the complementation response was elucidated by mitotic and meiotic gene conversion. Each allele probably carries an unaltered 7-site mutation and a unique second-site alteration. The s...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::Telomeric DNA repeats are key features of chromosomes that allow the maintenance of integrity and stability in the telomeres. However, interstitial telomere sites (ITSs) can also be found along the chromosomes, especially near the centromere, where they may appear following chromosomal rearrangements like Robertsonian...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.166421
更新日期:2014-08-01 00:00:00
abstract::If multiple linked polymorphisms are under natural selection, then conflicts arise and the efficiency of natural selection is hindered relative to the case of no linkage. This simple interaction between linkage and natural selection creates an opportunity for mutations that raise the level of recombination to increase...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and evince hyperactive transcription of Ste i...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::AFLP markers are becoming one of the most popular tools for genetic analysis in the fields of evolutionary genetics and ecology and conservation of genetic resources. The technique combines a high-information content and fidelity with the possibility of carrying out genomewide scans. However, a potential problem with ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.083246
更新日期:2008-05-01 00:00:00
abstract::Insulin-like growth factors (IGFs) control cell and organism growth through evolutionarily conserved signaling pathways. The mammalian acid-labile subunit (ALS) is a secreted protein that complexes with IGFs to modulate their activity. Recent work has shown that a Drosophila homolog of ALS, dALS, can also complex with...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.099531
更新日期:2009-04-01 00:00:00
abstract::Loss of heterozygosity (LOH) can be a driving force in the evolution of mitotic/somatic diploid cells, and cellular changes that increase the rate of LOH have been proposed to facilitate this process. In the yeast Saccharomyces cerevisiae, spontaneous LOH occurs by a number of mechanisms including chromosome loss and ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.089250
更新日期:2008-07-01 00:00:00
abstract::Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::The micronutrient boron is essential in maintaining the structure of plant cell walls and is critical for high yields in crop species. Boron can move into plants by diffusion or by active and facilitated transport mechanisms. We recently showed that mutations in the maize boron efflux transporter ROTTEN EAR (RTE) caus...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.198275
更新日期:2017-08-01 00:00:00
abstract::We have selected 210 mutants able to grow on sucrose in the presence of 2-deoxyglucose. We identified recessive mutations in three major complementation groups that cause constitutive (glucose-insensitive) secreted invertase synthesis. Two groups comprise alleles of the previously identified HXK2 and REG1 genes, and t...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract::We examined the inheritance of allelic variation at an isozyme locus, MDH-B, duplicated by ancestral polyploidy in salmonid fishes. We detected only disomic segregation in females. Segregation ratios in males were best explained by a mixture of disomic and tetrasomic inheritance. We propose a two-stage model of pairin...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Maize (Zea mays L.) serves as model plant for heterosis research and is the crop where hybrid breeding was pioneered. We analyzed genomic and phenotypic data of 1254 hybrids of a typical maize hybrid breeding program based on the important Dent × Flint heterotic pattern. Our main objectives were to investigate genome ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165860
更新日期:2014-08-01 00:00:00
abstract::Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward simulation, coalescent theory, or the diffusion approximation, have been applied extensively for demographic inference, medical study des...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.200493
更新日期:2017-07-01 00:00:00
abstract::We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.200063
更新日期:2017-05-01 00:00:00
abstract::In Arabidopsis thaliana, significant efforts to determine the extent of genomic variation between phenotypically divergent accessions are under way, but virtually nothing is known about variation at the transcription level. We used microarrays to examine variation in transcript abundance among three inbred lines and t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.041509
更新日期:2005-11-01 00:00:00
abstract::Reversion from the suppressed to nonsuppressed phenotype in strains of geno;type SUQ5 [psi+] ade2-1 his5-2 lys1-1 can1-100 ura3-1 has been induced by treatment with ethyl methanesulphonate, nitrosoguanidine or UV (254 nm) light. Spontaneously occurring revertants have also been selected by two different methods. Rever...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.138214
更新日期:2012-03-01 00:00:00