Abstract：
:Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward simulation, coalescent theory, or the diffusion approximation, have been applied extensively for demographic inference, medical study design, and evolutionary studies. Here we propose a tractable model of ordinary differential equations for the evolution of allele frequencies that is closely related to the diffusion approximation but avoids many of its limitations and approximations. We show that the approach is typically faster, more numerically stable, and more easily generalizable than the state-of-the-art software implementation of the diffusion approximation. We present a number of applications to human sequence data, including demographic inference with a five-population joint frequency spectrum and a discussion of the robustness of the out-of-Africa model inference to the choice of modern population.
journal_name
Geneticsjournal_title
Geneticsauthors
Jouganous J,Long W,Ragsdale AP,Gravel Sdoi
10.1534/genetics.117.200493subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1549-1567issue
3eissn
0016-6731issn
1943-2631pii
genetics.117.200493journal_volume
206pub_type
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