Abstract:
:Expectations for the time scale and structure of allelic genealogies in finite populations are formed under three models of sporophytic self-incompatibility. The models differ in the dominance interactions among the alleles that determine the self-incompatibility phenotype: In the SSIcod model, alleles act codominantly in both pollen and style, in the SSIdom model, alleles form a dominance hierarchy, and in SSIdomcod, alleles are codominant in the style and show a dominance hierarchy in the pollen. Coalescence times of alleles rarely differ more than threefold from those under gametophytic self-incompatibility, and transspecific polymorphism is therefore expected to be equally common. The previously reported directional turnover process of alleles in the SSIdomcod model results in coalescence times lower and substitution rates higher than those in the other models. The SSIdom model assumes strong asymmetries in allelic action, and the most recessive extant allele is likely to be the most recent common ancestor. Despite these asymmetries, the expected shape of the allele genealogies does not deviate markedly from the shape of a neutral gene genealogy. The application of the results to sequence surveys of alleles, including interspecific comparisons, is discussed.
journal_name
Geneticsjournal_title
Geneticsauthors
Schierup MH,Vekemans X,Christiansen FBsubject
Has Abstractpub_date
1998-11-01 00:00:00pages
1187-98issue
3eissn
0016-6731issn
1943-2631journal_volume
150pub_type
杂志文章相关文献
GENETICS文献大全abstract::The breeding systems of many organisms are cryptic and difficult to investigate with observational data, yet they have profound effects on a species' ecology, evolution, and genome organization. Genomic approaches offer a novel, indirect way to investigate breeding systems, specifically by studying the transmission of...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.179879
更新日期:2015-11-01 00:00:00
abstract::We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.160697
更新日期:2014-03-01 00:00:00
abstract::Estimating the fixation probability of a beneficial mutation has a rich history in theoretical population genetics. Typically, to attain mathematical tractability, we assume that generation times are fixed, while the number of offspring per individual is stochastic. However, fixation probabilities are extremely sensit...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.072009
更新日期:2007-07-01 00:00:00
abstract::Conversion between duplicated genes limits their independent evolution. Models in which conversion frequencies decrease as genes diverge are examined to determine conditions under which genes can "escape" further conversion and hence escape from a gene family. A review of results from various recombination systems sug...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract::The type of variegation of eyes of white-mottled mutants of D. hydei, either small-spotted or large-spotted, depends on the specific chromosome rearrangement involved. This distinction between mutants, though handsome, is not absolute because very seldomly small-spotted types do show a larger pigment aggregate and som...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-10-01 00:00:00
abstract::In eukaryotic cells, the organization of genomic DNA into chromatin regulates many biological processes, from the control of gene expression to the regulation of chromosome segregation. The proper maintenance of this structure upon cell division is therefore of prime importance during development for the maintenance o...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.190785
更新日期:2017-01-01 00:00:00
abstract::The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.040022
更新日期:2005-06-01 00:00:00
abstract::It is well known that most new mutations that affect fitness exert deleterious effects and that natural populations are often composed of subpopulations (demes) connected by gene flow. To gain a better understanding of the joint effects of purifying selection and population structure, we focus on a scenario where an a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178558
更新日期:2015-12-01 00:00:00
abstract::Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::The sojourn times until fixation of an overdominant allele were investigated based on the diffusion equation. Furthermore, the rate of accumulation of mutations, or the substitution rate, was predicted from the mean extinction time of a common overdominant allele. The substitution rate calculated theoretically agreed ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::Equilibria are determined for the two-locus model in a partially selfing population when one locus is neutral and the other locus is heterotic. At an equilibrium point, the frequency of heterozygotes at the neutral locus is greater than that expected from one-locus theory, even if the heterotic locus is on a different...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::The time of the pre-meiotic S-period was determined by (32)P incorporation in synchronously germinating zygospores of Chlamydomonas reinhardi at six and one-half to seven hours after the beginning of germination. Phenethyl alcohol treatment caused death of zygospores at a period one hour before the S-period, and also ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
abstract::We developed stochastic population genetic theory for mitochondrial and chloroplast genes, using an infinite alleles model appropriate for molecular genetic data. We considered the effects of mutation, random drift, and migration in a finite island model on selectively neutral alleles. Recurrence equations were obtain...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Abnormalities in chromosome number that occurred during meiosis were evaluated with a specially-constructed diploid strain of Saccharomyces cerevisiae. The strain is heterozygous for six markers of the right arm of chromosome V and heterozygous for cyh2 (resistance to cycloheximide) on chromosome VII.-Selection of mei...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
abstract::Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as commercially important organisms. Gene targeting by homologous recombination during transformation is possible in A. nidulans, but the frequency of correct gene ta...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.052563
更新日期:2006-03-01 00:00:00
abstract::We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic drive, each providing distinct functions th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Malaria control projects based on the introduction and spread of transgenes into mosquito populations depend on the extent of isolation between those populations. On the basis of the distribution of paracentric inversions, Anopheles gambiae has been subdivided into five subspecific chromosomal forms. Estimating gene f...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.026534
更新日期:2005-01-01 00:00:00
abstract::In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::We present a genetic map based on microsatellite polymorphisms for the African human malaria vector, Anopheles gambiae. Polymorphisms in laboratory strains were detected for 89% of the tested microsatellite markers. Genotyping was performed for individual mosquitos from 13 backcross families that included 679 progeny....
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::Genomic resources for hundreds of species of evolutionary, agricultural, economic, and medical importance are unavailable due to the expense of well-assembled genome sequences and difficulties with multigenerational studies. Teleost fish provide many models for human disease but possess anciently duplicated genomes th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.127324
更新日期:2011-08-01 00:00:00
abstract::The net rate of mutation to deleterious but nonlethal alleles and the sizes of effects of these mutations are of great significance for many evolutionary questions. Here we describe three replicate experiments in which mutations have been accumulated on chromosome 3 of Drosophila melanogaster by means of single-male b...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.103.025262
更新日期:2004-06-01 00:00:00
abstract::Knowledge of multigenic family organization should provide insight into their mode of evolution. Accordingly, we characterized the 5S ribosomal gene family in the Drosophila melanogaster strain ry506. The 5S genes in this strain display a striking HindIII restriction difference compared to the "standard" D. melanogast...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::Paramutation generates heritable changes affecting regulation of specific alleles found at several Zea mays (maize) loci that encode transcriptional regulators of anthocyanin biosynthetic genes. Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diplo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.045260
更新日期:2005-10-01 00:00:00
abstract::When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.073072
更新日期:2007-07-01 00:00:00
abstract::The isolation of mutants of Saccharomyces cerevisiae that divide at approximately half the size of the wild type is described. Three mutants have been isolated in which the small size at bud initiation is due to a mutation in a single nuclear gene. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract::Data are presented for 2,393 progeny from a number of crosses related to a study in ecological genetics of the Burnsi and Kandiyohi polymorphisms in natural populations of the leopard frog, Rana pipiens. No significant differences in viability were found between wild-type homozygotes (+/+) and Burnsi heterozygotes (B/...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-01-01 00:00:00
abstract::The primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptide...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::In multigene families, variation among loci and alleles can contribute to trait evolution. We explored patterns of functional and genetic variation in six duplicated Arabidopsis thaliana trypsin inhibitor (ATTI) loci. We demonstrate significant variation in constitutive and herbivore-induced transcription among ATTI l...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.166.3.1419
更新日期:2004-03-01 00:00:00
abstract::An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters containing 4607 genes, over one-fifth of all genes in C. elegans. Cluster genes are distributed unevenly in the genome, with t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.040030
更新日期:2006-01-01 00:00:00
abstract::Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.127746
更新日期:2011-06-01 00:00:00