Abstract：
:Abnormalities in chromosome number that occurred during meiosis were evaluated with a specially-constructed diploid strain of Saccharomyces cerevisiae. The strain is heterozygous for six markers of the right arm of chromosome V and heterozygous for cyh2 (resistance to cycloheximide) on chromosome VII.-Selection of meiotic spores on a medium containing cycloheximide and required nutrilites-except those for the markers of the right arm of chromosome V-allows the growth of aberrant clones belonging only to two classes: a) diploid clones, caused by failure of the second meiotic division, with a frequency of 0.54 x 10(-4) per viable spore; and b) diplo V, aneuploids derived from nondisjunctions in meiosis I or meiosis II, with a total spontaneous frequency of 0.95 x 10(-4) per viable spore. About two-thirds of the aneuploids originated during meiosis I, the rest during meiosis II. An investigation of these events in control meioses and after treatment with MMS, Benomyl and Amphotericin B suggests that this assay system is suitable for screening environmental mutagens for their effects on meiotic segregation.
journal_name
Geneticsjournal_title
Geneticsauthors
Sora S,Lucchini G,Magni GEsubject
Has Abstractpub_date
1982-05-01 00:00:00pages
17-33issue
1eissn
0016-6731issn
1943-2631journal_volume
101pub_type
杂志文章相关文献
GENETICS文献大全abstract：:In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-08-01 00:00:00
abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.119.300240
更新日期：2020-02-01 00:00:00
abstract：:Over one-third of human genome sequence is a product of non-LTR retrotransposition. The retrotransposon that currently drives this process in humans is the highly abundant LINE-1 (L1) element. Despite the ubiquitous nature of L1's in mammals, we still lack a complete mechanistic understanding of the L1 replication cyc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.096636
更新日期：2009-01-01 00:00:00
abstract：:This report examines five different naturally occurring alcohol dehydrogenase-1 alleles via the recombinational behavior of Adh1(-) mutants induced within them. Twenty-two biochemically characterized Adh1(-) mutants have been assessed for ability to recombine intragenically, using data generated by specifically staini...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
abstract：:Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggest...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-02-01 00:00:00
abstract：:I factors in Drosophila melanogaster are non-LTR retrotransposons that transpose at very high frequencies in the germ line of females resulting from crosses between reactive females (devoid of active I factors) and inducer males (containing active I factors). Constructs containing I factor ORF1 under the control of th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:A sulfonamide-resistant mutant of pneumococcus, sulr-c, displays a genetic instability, regularly segregating to wild type. DNA extracts of derivatives of the strain possess transforming activities for both the mutant and wild-type alleles, establishing that the strain is a partial diploid. The linkage of sulr-c to st...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:We examined linkage relationships for RecBC-mediated recombination in lytic cycle crosses of lambda phages bearing two cohesive end sites (cos) oriented in the same direction. The relationships obtained imply that a given recombinant tends to be packaged from the cos site that is the nearer one to the right of the exc...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:Following the advent of a gene targeting technique in Drosophila, different methods have been developed to modify the Drosophila genome. The initial demonstration of gene targeting in flies used an ends-in method, which generates a duplication of the target locus. The duplicated locus can then be efficiently reduced t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.030882
更新日期：2004-11-01 00:00:00
abstract：:The DNA-binding protein encoded by the zeste gene of Drosophila activates transcription and mediates interchromosomal interactions such as transvection. The mutant protein encoded by the zeste1 (z1) allele retains the ability to support transvection, but represses white. Similar to transvection, repression requires Ze...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:The experimental population genetics of Y-chromosome drive in Drosophila melanogaster is approximated by studying the behavior of T(Y;2),SD lines. These exhibit "pseudo-Y" drive through the effective coupling of the Y chromosome to the second chromosome meiotic drive locus, Segregation distorter (SD). T(Y;2),SD males ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:Specific mutations in the gene encoding the largest subunit of RNA polymerase II (RpII215) cause a partial transformation of a structure of the third thoracic segment, the capitellum, into the analogous structure of the second thoracic segment, the wing. This mutant phenotype is also caused by genetically reducing the...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S phase in yeast by overproducing a deregulated form of Swi4 (Swi4-t). Swi4 is a late G1-specific transcriptional activat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmen...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.051144
更新日期：2006-02-01 00:00:00
abstract：:Most studies of mutation rates implicitly assume that they remain constant throughout development of the germline. However, researchers recently used a novel statistical framework to reveal that mutation rates differ dramatically during sperm development in Drosophila melanogaster. Here a general framework is describe...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.151571
更新日期：2013-08-01 00:00:00
abstract：:The Drosophila piwi gene is the founding member of the only known family of genes whose function in stem cell maintenance is highly conserved in both animal and plant kingdoms. piwi mutants fail to maintain germline stem cells in both male and female gonads. The identification of piwi-interacting genes is essential fo...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:We have characterized Unstable factor for orange1 (Ufo1), a dominant, allele-specific modifier of expression of the maize pericarp color1 (p1) gene. The p1 gene encodes an Myb-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The P1-wr allele specifies colorless kerne...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Our understanding of the cellular mechanisms by which animals regulate their response to starvation is limited, despite the strong relevance of the problem to major human health issues. The L1 diapause of Caenorhabditis elegans, where first-stage larvae arrest in response to a food-less environment, is an excellent sy...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.194282
更新日期：2017-02-01 00:00:00
abstract：:The long terminal repeat retrotransposon, Magnaporthe gypsy-like element (MAGGY), has been shown to be targeted for cytosine methylation in a subset of Magnaporthe oryzae field isolates. Analysis of the F1 progeny from a genetic cross between methylation-proficient (Br48) and methylation-deficient (GFSI1-7-2) isolates...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.155978
更新日期：2013-11-01 00:00:00
abstract：:In this article we investigate multiplicative effects between genes in relation to heterosis. The extensive literature on heterosis due to multiplicative effects between characters is reviewed, as is earlier work on the genetic description of heterosis. A two-locus diallelic model of arbitrary gene action is used to d...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) are an important family of signaling molecules with the unusual property that they are able to transduce their signals using the same downstream pathways. This has led to an unresolved debate as to whether individual receptors are interchangeable, or if each receptor can mediate specif...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.098475
更新日期：2009-04-01 00:00:00
abstract：:We have determined the complete nucleotide sequence of the mitochondrial DNA (mtDNA) of the dogfish, Scyliorhinus canicula. The 16,697-bp-long mtDNA possesses a gene organization identical to that of the Osteichthyes, but different from that of the sea lamprey Petromyzon marinus. The main features of the mtDNA of oste...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Mutagenic DNA repair (MDR) employs low-fidelity DNA polymerases capable of replicating past DNA lesions resulting from exposure to high-energy ultraviolet radiation (UVR). MDR confers UVR tolerance and activation initiates a transient mutator phenotype that may provide opportunities for adaptation. To investigate the ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.096131
更新日期：2009-01-01 00:00:00
abstract：:Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genet...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.052977
更新日期：2006-07-01 00:00:00
abstract：:Mutator and antimutator alleles often arise and spread in both natural microbial populations and laboratory evolution experiments. The evolutionary dynamics of these mutation rate modifiers are determined by indirect selection on linked beneficial and deleterious mutations. These indirect selection pressures have been...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.193565
更新日期：2016-11-01 00:00:00
abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.200063
更新日期：2017-05-01 00:00:00
abstract：:To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
