Abstract：
:Our understanding of the cellular mechanisms by which animals regulate their response to starvation is limited, despite the strong relevance of the problem to major human health issues. The L1 diapause of Caenorhabditis elegans, where first-stage larvae arrest in response to a food-less environment, is an excellent system to study this mechanism. We found, through genetic manipulation and lipid analysis, that biosynthesis of ceramide, particularly those with longer fatty acid side chains, critically impacts animal survival during L1 diapause. Genetic interaction analysis suggests that ceramide may act in both insulin-IGF-1 signaling (IIS)-dependent and IIS-independent pathways to affect starvation survival. Genetic and expression analyses indicate that ceramide is required for maintaining the proper expression of previously characterized starvation-responsive genes, genes that are regulated by the IIS pathway and tumor suppressor Rb, and genes responsive to pathogen. These findings provide an important insight into the roles of sphingolipid metabolism, not only in starvation response, but also in aging and food-response-related human health problems.
journal_name
Geneticsjournal_title
Geneticsauthors
Cui M,Wang Y,Cavaleri J,Kelson T,Teng Y,Han Mdoi
10.1534/genetics.116.194282subject
Has Abstractpub_date
2017-02-01 00:00:00pages
775-785issue
2eissn
0016-6731issn
1943-2631pii
genetics.116.194282journal_volume
205pub_type
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