Intragenic suppression at the b2 locus in Ascobolus immersus. I. Identification of three distinct groups of suppression.

abstract：:Mutation frequency and specificity were determined as a function of age in nuclear DNA from liver, bladder, and brain of Big Blue lacI transgenic mice aged 1.5-25 months. Mutations accumulated with age in liver and accumulated more rapidly in bladder. In the brain a small initial increase in mutation frequency was obs...

journal_title：Genetics

authors： Stuart GR,Oda Y,de Boer JG,Glickman BW

更新日期：2000-03-01 00:00:00

abstract：:A maximum-likelihood method to estimate the recombination fraction and its sampling variance using informative and noninformative half-sib offspring is derived. Estimates of the recombination fraction are biased up to 20 cM when noninformative offspring are discarded. In certain scenarios, the sampling variance can be...

journal_title：Genetics

authors： Gomez-Raya L

更新日期：2001-03-01 00:00:00

abstract：:DNA amounts in macronuclei and micronuclei of Tetrahymena pyriformis were measured by Feulgen microspectrophotometry. Assuming that the unreplicated micronucleus is diploid, the unreplicated macronucleus was found to contain approximately 45 times the haploid DNA amount. The relationship of these findings to the 45 in...

journal_title：Genetics

authors： Woodard J,Kaneshiro E,Gorovsky MA

更新日期：1972-02-01 00:00:00

abstract：:The formation and stability of epigenetically regulated chromatin is influenced by DNA replication and factors that modulate post-translational modifications on histones. Here we describe evidence that PCNA can affect silencing in Saccharomyces cerevisiae by facilitating deposition of H3 K56ac onto chromosomes. We pro...

journal_title：Genetics

authors： Miller A,Yang B,Foster T,Kirchmaier AL

更新日期：2008-06-01 00:00:00

abstract：:A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing less than 0.7% ...

journal_title：Genetics

authors： Karolyi J,Erickson RP,Liu S,Killewald L

更新日期：1990-09-01 00:00:00

abstract：:We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotype...

journal_title：Genetics

authors： Parker L,Padilla M,Du Y,Dong K,Tanouye MA

更新日期：2011-02-01 00:00:00

abstract：:The Saccharomyces cerevisiae PHO85 gene encodes a nonessential cyclin-dependent kinase that associates with 10 cyclin subunits. To survey the functions provided by Pho85, we identified mutants that require PHO85 for viability. We identified mutations that define seven Pho Eighty-Five Requiring or Efr loci, six of whic...

journal_title：Genetics

authors： Lenburg ME,O'Shea EK

更新日期：2001-01-01 00:00:00

abstract：:In this article, we utilize stochastic search variable selection methodology to develop a Bayesian method for identifying multiple quantitative trait loci (QTL) for complex traits in experimental designs. The proposed procedure entails embedding multiple regression in a hierarchical normal mixture model, where latent ...

journal_title：Genetics

authors： Yi N,George V,Allison DB

更新日期：2003-07-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:Log-linear analysis of contingency tables is applied to trihybrid backcross data to estimate linkage and viability. Whereas nonadditive viability differences perturb recombination estimates in the classical analysis, this statistical procedure yields maximum likelihood crossover frequency estimates in the presence of ...

journal_title：Genetics

authors： Clark AG

更新日期：1981-09-01 00:00:00

abstract：:Determining parentage is a fundamental problem in biology and in applications such as identifying pedigrees. Difficulties inferring parentage derive from extensive inbreeding within the population, whether natural or planned; using an insufficient number of hypervariable loci; and from allele mismatches caused by muta...

journal_title：Genetics

authors： Berry DA,Seltzer JD,Xie C,Wright DL,Jones ES,Sebastian S,Smith JS

更新日期：2003-09-01 00:00:00

abstract：:Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, su...

journal_title：Genetics

authors： Ard R,Allshire RC,Marquardt S

更新日期：2017-10-01 00:00:00

abstract：:The unicellular green alga Chlamydomonas reinhardtii is used extensively as a model to study eukaryotic photosynthesis, flagellar functions, and more recently the production of hydrogen as biofuel. Two of these processes, photosynthesis and hydrogen production, are highly dependent on iron-sulfur (Fe-S) enzymes. To un...

journal_title：Genetics

authors： Godman J,Balk J

更新日期：2008-05-01 00:00:00

abstract：:Whole-mount fluorescence in situ hybridization (FISH) was applied to Arabidopsis thaliana seedlings to determine the three-dimensional (3D) interphase chromosome territory (CT) arrangement and heterochromatin location within the positional context of entire tissues or in particular cell types of morphologically well-p...

journal_title：Genetics

authors： Berr A,Schubert I

更新日期：2007-06-01 00:00:00

abstract：:During development signaling pathways coordinate cell fates and regulate the choice between cell survival or programmed cell death. The well-conserved Wingless/Wnt pathway is required for many developmental decisions in all animals. One transducer of the Wingless/Wnt signal is Armadillo/beta-catenin. Drosophila Armadi...

journal_title：Genetics

authors： Cox RT,McEwen DG,Myster DL,Duronio RJ,Loureiro J,Peifer M

更新日期：2000-08-01 00:00:00

abstract：:Due to issues of practicality and confidentiality of genomic data sharing on a large scale, typically only meta- or mega-analyzed genome-wide association study (GWAS) summary data, not individual-level data, are publicly available. Reanalyses of such GWAS summary data for a wide range of applications have become more ...

journal_title：Genetics

authors： Deng Y,Pan W

更新日期：2018-06-01 00:00:00

abstract：:For multiallelic loci, standard measures of linkage disequilibrium provide an incomplete description of the correlation of variation at two loci, especially when there are different numbers of alleles at the two loci. We have developed a complementary pair of conditional asymmetric linkage disequilibrium (ALD) measure...

journal_title：Genetics

authors： Thomson G,Single RM

更新日期：2014-09-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:Over 100 regulatory mutations linked to the histidine (his) operon of S. typhimurium have been isolated. They all map in a region estimated to be several hundred base pairs in length located at one end of the his operon ("the hisO region"). The mutations are located at sixteen recombinationally separable sites or are ...

journal_title：Genetics

authors： Ely B,Fankhauser DB,Hartman PE

更新日期：1974-10-01 00:00:00

abstract：:The prion-like behavior of Sup35p, the eRF3 homolog in the yeast Saccharomyces cerevisiae, mediates the activity of the cytoplasmic nonsense suppressor known as [PSI(+)]. Sup35p is divided into three regions of distinct function. The N-terminal and middle (M) regions are required for the induction and propagation of [...

journal_title：Genetics

authors： Jensen MA,True HL,Chernoff YO,Lindquist S

更新日期：2001-10-01 00:00:00

abstract：:Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...

journal_title：Genetics

authors： Seier T,Padgett DR,Zilberberg G,Sutera VA Jr,Toha N,Lovett ST

更新日期：2011-06-01 00:00:00

abstract：:There is an increasing awareness that selection affecting linked neutral sites strongly influences on how diversity is distributed across the genome. In particular, linked selection is likely involved in the formation of heterogenous landscapes of genetic diversity, including genomic regions with locally reduced effec...

journal_title：Genetics

authors： Rettelbach A,Nater A,Ellegren H

更新日期：2019-05-01 00:00:00

abstract：:Though much has been learned about the process of ovarian follicle maturation through studies of oogenesis in both vertebrate and invertebrate systems, less is known about how follicles form initially. In Drosophila, two somatic follicle stem cells (FSCs) in each ovariole give rise to all polar cells, stalk cells, and...

journal_title：Genetics

authors： Nystul T,Spradling A

更新日期：2010-02-01 00:00:00

abstract：:Many genetic variants identified in genome-wide association studies (GWAS) are associated with multiple, sometimes seemingly unrelated, traits. This motivates multi-trait association analyses, which have successfully identified novel associated loci for many complex diseases. While appealing, most existing methods foc...

journal_title：Genetics

authors： Wu C

更新日期：2020-08-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:Condensins are evolutionarily conserved protein complexes that are required for chromosome segregation during cell division and genome organization during interphase. In Caenorhabditis elegans, a specialized condensin, which forms the core of the dosage compensation complex (DCC), binds to and represses X chromosome t...

journal_title：Genetics

authors： Street LA,Morao AK,Winterkorn LH,Jiao CY,Albritton SE,Sadic M,Kramer M,Ercan S

更新日期：2019-07-01 00:00:00

abstract：:This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...

journal_title：Genetics

authors： Miller CJ,Carlson JR

更新日期：2010-09-01 00:00:00

abstract：:Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethality preceded by the o...

journal_title：Genetics

authors： Djagaeva I,Rose DJ,Lim A,Venter CE,Brendza KM,Moua P,Saxton WM

更新日期：2012-09-01 00:00:00

abstract：:In a recent not in this journal (MARUYAMA 1973), one of us has considered, for a certain genetic model, the variance of the distribution of the number of loci having a given gene frequency. The formula given is incorrect. This brief note considers this problem and notes the correct solution in one particular case. ...

journal_title：Genetics

authors： Ewens WJ

更新日期：1975-05-01 00:00:00

abstract：:The genetic etiology of many complex diseases is highly heterogeneous. A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci. Although these disease-susceptibility mutations can be collectively common in the population, they are often individu...

journal_title：Genetics

authors： Li M,He Z,Tong X,Witte JS,Lu Q

更新日期：2018-10-01 00:00:00