Genome analysis of Chlamydomonas reinhardtii reveals the existence of multiple, compartmentalized iron-sulfur protein assembly machineries of different evolutionary origins.

abstract：:Genetic study of the reproductive barriers between related species plays an essential role in understanding the process of speciation. We developed a new method for mapping all possible factors causing deviations from expected Mendelian segregation ratios in F(2) progeny, which substantially contribute to reproductive...

journal_title：Genetics

authors： Harushima Y,Nakagahra M,Yano M,Sasaki T,Kurata N

更新日期：2001-10-01 00:00:00

abstract：:Position effect variegation results from chromosome rearrangements which translocate euchromatic genes close to the heterochromatin. The euchromatin-heterochromatin association is responsible for the inactivation of these genes in some cell clones. In Drosophila melanogaster the Y chromosome, which is entirely heteroc...

journal_title：Genetics

authors： Dimitri P,Pisano C

更新日期：1989-08-01 00:00:00

abstract：:Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneu...

journal_title：Genetics

authors： Lindahl KF,Hausmann B

更新日期：1983-03-01 00:00:00

abstract：:In diploid Saccharomyces cerevisiae cells, bud-site selection is determined by two cortical landmarks, Bud8p and Bud9p, at the distal and proximal poles, respectively. Their localizations depend on the multigenerational proteins Rax1p/Rax2p. Many genes involved in bud-site selection were identified previously by genom...

journal_title：Genetics

authors： Kato Y,Kawasaki H,Ohyama Y,Morishita T,Iwasaki H,Kokubo T,Hirano H

更新日期：2011-08-01 00:00:00

abstract：:Recombination of phage lambda attachment sites occurs by sequential exchange of the DNA strands at two specific locations. The first exchange produces a Holliday structure, and the second resolves it to recombinant products. Heterology for base substitution mutations in the region between the two strand exchange point...

journal_title：Genetics

authors： Bauer CE,Gardner JF,Gumport RI,Weisberg RA

更新日期：1989-08-01 00:00:00

abstract：:Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...

journal_title：Genetics

authors： Fine RD,Maqani N,Li M,Franck E,Smith JS

更新日期：2019-05-01 00:00:00

abstract：:Methodologies for mapping of genes underlying quantitative traits have advanced considerably but have not been accompanied by a parallel development of new population structures. We present a novel population consisting of 50 introgression lines (ILs) originating from a cross between the green-fruited species Lycopers...

journal_title：Genetics

authors： Eshed Y,Zamir D

更新日期：1995-11-01 00:00:00

abstract：:An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters containing 4607 genes, over one-fifth of all genes in C. elegans. Cluster genes are distributed unevenly in the genome, with t...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-01-01 00:00:00

abstract：:The rag4 mutant of Kluyveromyces lactis was previously isolated as a fermentation-deficient mutant, in which transcription of the major glucose transporter gene RAG1 was affected. The wild-type RAG4 was cloned by complementation of the rag4 mutation and found to encode a protein homologous to Snf3 and Rgt2 of Saccharo...

journal_title：Genetics

authors： Betina S,Goffrini P,Ferrero I,Wésolowski-Louvel M

更新日期：2001-06-01 00:00:00

abstract：:It is well known that most new mutations that affect fitness exert deleterious effects and that natural populations are often composed of subpopulations (demes) connected by gene flow. To gain a better understanding of the joint effects of purifying selection and population structure, we focus on a scenario where an a...

journal_title：Genetics

authors： Zeng K,Corcoran P

更新日期：2015-12-01 00:00:00

abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...

journal_title：Genetics

authors： Uricchio LH,Hernandez RD

更新日期：2014-05-01 00:00:00

abstract：:This FlyBook chapter summarizes the history and the current state of our understanding of the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molec...

journal_title：Genetics

authors： Bejsovec A

更新日期：2018-04-01 00:00:00

abstract：:Conversion between duplicated genes limits their independent evolution. Models in which conversion frequencies decrease as genes diverge are examined to determine conditions under which genes can "escape" further conversion and hence escape from a gene family. A review of results from various recombination systems sug...

journal_title：Genetics

authors： Walsh JB

更新日期：1987-11-01 00:00:00

abstract：:Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...

journal_title：Genetics

authors： Kugler SJ,Gehring EM,Wallkamm V,Krüger V,Nagel AC

更新日期：2011-05-01 00:00:00

abstract：:Reproducing kernel Hilbert spaces regression procedures for prediction of total genetic value for quantitative traits, which make use of phenotypic and genomic data simultaneously, are discussed from a theoretical perspective. It is argued that a nonparametric treatment may be needed for capturing the multiple and com...

journal_title：Genetics

authors： Gianola D,van Kaam JB

更新日期：2008-04-01 00:00:00

abstract：:We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of approximately 300 genes encoding seven-pass G-protein-coupled receptors. Almost one-third of the genes in each family are annotated as pseudogenes because of apparent functional defects...

journal_title：Genetics

authors： Stewart MK,Clark NL,Merrihew G,Galloway EM,Thomas JH

更新日期：2005-04-01 00:00:00

abstract：:Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage-fusion-bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Cu...

journal_title：Genetics

authors： Lowden MR,Meier B,Lee TW,Hall J,Ahmed S

更新日期：2008-10-01 00:00:00

abstract：:Accounting for gene-environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanism...

journal_title：Genetics

authors： Zhao G,Marceau R,Zhang D,Tzeng JY

更新日期：2015-03-01 00:00:00

abstract：:We developed a screening approach that utilizes an inverse polymerase chain reaction (PCR) to detect P element insertions in or near previously cloned genes in Drosophila melanogaster. We used this approach in a large scale genetic screen in which P elements were mobilized from sites on the X chromosome to new autosom...

journal_title：Genetics

authors： Dalby B,Pereira AJ,Goldstein LS

更新日期：1995-02-01 00:00:00

abstract：:The infinite-sites model with no recombination is extended to include mutations that affect electrophoretic mobility. The model allows the effect of a single-site mutation to have a continuous effect on mobility. Formulae are obtained for the variance of electrophoretic mobility of alleles after an arbitrary lenght of...

journal_title：Genetics

authors： Cobbs G

更新日期：1979-06-01 00:00:00

abstract：:Acrylamide gel electrophoresis was performed on the enzyme xanthine dehydrogenase in sixty isochromosomal lines of Drosophila persimilis from three geographic populations. Sequential electrophoretic analysis using varied gel concentrations and buffers revealed twenty-three alleles in this species where only five had b...

journal_title：Genetics

authors： Coyne JA

更新日期：1976-11-01 00:00:00

abstract：:Microsatellites have been widely used as tools for population studies. However, inference about population processes relies on the specification of mutation parameters that are largely unknown and likely to differ across loci. Here, we use data on somatic mutations to investigate the mutation process at 14 tetranucleo...

journal_title：Genetics

authors： Gonser R,Donnelly P,Nicholson G,Di Rienzo A

更新日期：2000-04-01 00:00:00

abstract：:Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved by two functionally similar but structurally distinct processes in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe In ...

journal_title：Genetics

authors： Hanson SJ,Wolfe KH

更新日期：2017-05-01 00:00:00

abstract：:Heterochromatin is a specialized chromatin structure in chromosomal regions associated with repeated DNA sequences and low concentrations of genes. Formation of heterochromatin is determined in large part by enzymes that modify histones and structural proteins that bind to these modified histones in a cooperative fash...

journal_title：Genetics

authors： Mason JM,Ransom J,Konev AY

更新日期：2004-11-01 00:00:00

abstract：:In the present study, we investigated intrachromosomal homologous recombination in a murine hybridoma in which the recipient for recombination, the haploid, endogenous chromosomal immunoglobulin mu-gene bearing a mutation in the constant (Cmu) region, was separated from the integrated single copy wild-type donor Cmu r...

journal_title：Genetics

authors： Baker MD,Read LR,Ng P,Beatty BG

更新日期：1999-06-01 00:00:00

abstract：:Clustering individuals to subpopulations based on genetic data has become commonplace in many genetic studies. Inference about population structure is most often done by applying model-based approaches, aided by visualization using distance-based approaches such as multidimensional scaling. While existing distance-bas...

journal_title：Genetics

authors： Greenbaum G,Templeton AR,Bar-David S

更新日期：2016-04-01 00:00:00

abstract：:This paper describes a perturbation experiment on the frequency of the F and S Alcohol dehydrogenase (Adh) alleles of D. melanogaster. Fifty-four iso-female lines set up from three wild populations and with initial F frequencies of either 0.25, 0.50 or 0.75 were maintained on standard laboratory food medium at 22 degr...

journal_title：Genetics

authors： Wilson SR,Oakeshott JG,Gibson JB,Anderson PR

更新日期：1982-01-01 00:00:00

abstract：:Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, another DNA helicase, c...

journal_title：Genetics

authors： McVey M,Kaeberlein M,Tissenbaum HA,Guarente L

更新日期：2001-04-01 00:00:00

abstract：:The vertebrate limb serves as an experimental paradigm to study mechanisms that regulate development of the stereotypical skeletal elements. In this study, we simultaneously inactivated Sall4 using Hoxb6Cre and Plzf in mouse embryos, and found that their combined function regulates development of the proximal-anterior...

journal_title：Genetics

authors： Chen KQ,Tahara N,Anderson A,Kawakami H,Kawakami S,Nishinakamura R,Pandolfi PP,Kawakami Y

更新日期：2020-05-01 00:00:00

abstract：:The relationships between synonymous and nonsynonymous substitution rates and between synonymous rate and codon usage bias are important to our understanding of the roles of mutation and selection in the evolution of Drosophila genes. Previous studies used approximate estimation methods that ignore codon bias. In this...

journal_title：Genetics

authors： Dunn KA,Bielawski JP,Yang Z

更新日期：2001-01-01 00:00:00