Abstract：
:Genetic study of the reproductive barriers between related species plays an essential role in understanding the process of speciation. We developed a new method for mapping all possible factors causing deviations from expected Mendelian segregation ratios in F(2) progeny, which substantially contribute to reproductive isolation. A multiresponse nonlinear regression analysis of the allele frequencies of the markers covering an entire genome in the F(2) population was performed to estimate the map position and intensity of the reproductive barriers on each chromosome. In F(2) plants from a cross between a Japonica variety of rice, Nipponbare, and an Indica variety, Kasalath, the deviations of allele frequencies were well explained by 33 reproductive barriers. Of these, 15 reproductive barriers affected the allele transmission rate through the gametophyte and in 9 of these 15 cases, an Indica allele was transmitted at a higher frequency than a Japonica allele. The other 18 reproductive barriers altered the viability of the zygote via its genotype. Two zygotic reproductive barriers showed overdominance and 5 showed underdominance. The most pronounced reproductive barrier, mapped at 62.3 +/- 0.4 cM on chromosome 3, transmitted the Indica allele by 94% through the male gametophyte. The accuracy of the barrier position in the regression analysis was confirmed by progeny analysis. The regression analysis proved to be a powerful tool for detecting and characterizing every reproductive barrier, irrespective of whether it acted on the male or female gametophyte or the zygote.
journal_name
Geneticsjournal_title
Geneticsauthors
Harushima Y,Nakagahra M,Yano M,Sasaki T,Kurata Nkeywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
883-92issue
2eissn
0016-6731issn
1943-2631journal_volume
159pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Prions have revived interest in hereditary change that is due to change in cellular structure. How pervasive is structural inheritance and what are its mechanisms? Described here is the initial characterization of [Leu(P)], a heritable structural change of the mitochondrion of Saccharomyces cerevisiae that often but n...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. Thi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Tetrahymena is a useful eukaryotic model for biochemistry and molecular cell biology studies. We previously demonstrated that targeted ectopic DNA elimination, also called co-Deletion (coDel), can be induced by the introduction of an internal eliminated sequence (IES)-target DNA chimeric construct. In this study, we d...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.178525
更新日期：2015-09-01 00:00:00
abstract：:Proper levels of gene expression are important for normal mammalian development. Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality or birth defects. Segmental aneuploidy can be compatible with life but often results in contiguous gene syndromes. The ability to manipulate ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：:Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.111.135590
更新日期：2012-02-01 00:00:00
abstract：:The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an impo...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.039040
更新日期：2005-07-01 00:00:00
abstract：:In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.178160
更新日期：2015-12-01 00:00:00
abstract：:DNA repair of single-strand breaks (produced by ionizing radiation) and of base damage (produced by ultraviolet (UV) light) are two repair mechanisms that most mammalian cells possess. Genetic defects in these repair mechanisms are exemplified by cells from the human premature-aging disease, progeria, which fail to re...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmen...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.051144
更新日期：2006-02-01 00:00:00
abstract：:The sequentially Markov coalescent is a simplified genealogical process that aims to capture the essential features of the full coalescent model with recombination, while being scalable in the number of loci. In this article, the sequentially Markov framework is applied to the conditional sampling distribution (CSD), ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.125534
更新日期：2011-04-01 00:00:00
abstract：:The contribution of epigenetic alterations to natural variation for gene transcription levels remains unclear. In this study, we investigated the functional targets of the maize chromomethylase ZMET2 in multiple inbred lines to determine whether epigenetic changes conditioned by this chromomethylase are conserved or v...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.072702
更新日期：2007-10-01 00:00:00
abstract：:A multi-locus model for complete positive assortative mating is discussed. For a two-locus model, if the gene frequencies for the two loci are different, as they are likely to be, it is shown that in equilibrium the population is not composed of only two homozygous types, as is usually thought. The limiting distributi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1973-12-01 00:00:00
abstract：:The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.143818
更新日期：2012-10-01 00:00:00
abstract：:Regulation of transcription can be a complex process in which many cis- and trans-interactions determine the final pattern of expression. Among these interactions are trans-interactions mediated by the pairing of homologous chromosomes. These trans-effects are wide ranging, affecting gene regulation in many species an...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.111.133231
更新日期：2011-11-01 00:00:00
abstract：:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:We studied the control of pharyngeal excitation in Caenorhabditis elegans. By laser ablating subsets of the pharyngeal nervous system, we found that the MC neuron type is necessary and probably sufficient for rapid pharyngeal pumping. Electropharyngeograms showed that MC transmits excitatory postsynaptic potentials, s...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the fir...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301104
更新日期：2018-07-01 00:00:00
abstract：:The MITF protein is a member of the MYC family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors and is most closely related to the TFE3, TFEC, and TFEB proteins. In the mouse, MITF is required for the development of several different cell types, including the retinal pigment epithelial (RPE) c...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.167.1.233
更新日期：2004-05-01 00:00:00
abstract：:Damaged DNA-binding proteins 1 and 2 (DDB1 and DDB2) are subunits of the damaged DNA-binding protein complex (DDB). DDB1 is also found in the same complex as DE-ETIOLATED 1 (DET1), a negative regulator of light-mediated responses in plants. Arabidopsis has two DDB1 homologs, DDB1A and DDB1B. ddb1a single mutants have ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.070359
更新日期：2007-05-01 00:00:00
abstract：:A study of DNA polymorphism and divergence was conducted for the cytosolic phosphoglucose isomerase (PGI:E.C.5.3.1.9) gene of five species of the mustard genus Leavenworthia: Leavenworthia stylosa, L. alabamica, L. crassa, L. uniflora, and L. torulosa. Sequences of an internal 2.3-kb PgiC gene region spanning exons 6-...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.112.147207
更新日期：2013-03-01 00:00:00
abstract：:Selection of Gl-Sb coupling heterozygotes was carried out for more than one hundred generations commencing with six independent lines drawn from a common base population. Population sizes were eight, sixteen and forty-eight parents per generation. The effect of natural selection on recombination value was measured by ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1972-03-01 00:00:00
abstract：:The GAL4 protein of Saccharomyces cerevisiae binds to DNA upstream of each of six genes and stimulates their transcription. To locate regions of the protein responsible for these processes, we identified and characterized 88 gal4 mutations selected in vivo to reduce the ability to GAL4 protein to activate transcriptio...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：:Selection during evolution, whether natural or artificial, acts through the phenotype. For multifaceted phenotypes such as plant and inflorescence architecture, the underlying genetic architecture is comprised of a complex network of interacting genes rather than single genes that act independently to determine the tr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300071
更新日期：2017-10-01 00:00:00
abstract：:The dmd gene of bacteriophage T4 is required for regulation of mRNA stability in a stage-dependent manner during infection. When this gene is mutated, late genes are globally silenced because of rapid degradation of mRNAs. To investigate the mechanism of such mRNA degradation, we analyzed the late gene soc transcripts...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:We present the results of a restriction site survey of variation at five loci in Drosophila athabasca, complimenting a previous study of the period locus. There is considerably greater differentiation between the three semispecies of D. athabasca at the period locus and two other X-linked genes (no-on-transient-A and ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneu...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase c...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.151019
更新日期：2013-09-01 00:00:00
abstract：:Diversity in insect pigmentation, encompassing a wide range of colors and spatial patterns, is among the most noticeable features distinguishing species, individuals, and body regions within individuals. In holometabolous species, a significant portion of such diversity can be attributed to the melanin synthesis genes...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.186684
更新日期：2016-05-01 00:00:00
